Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Serge Y. Fuchs"'
Autor:
Frank Chinga, Serge Y. Fuchs, Zoya Ignatova, Jiangbin Ye, Crystal S. Conn, Weixuan Fu, Constantinos Koumenis, Andrew V. Kossenkov, Carlo Salas Salinas, Ioannis I. Verginadis, Nektaria Maria Leli, Ravi K. Amaravadi, Christine Polte, Paul P. Wang, Alexandra M Monroy, Davide Ruggero, J. Alan Diehl, Feven Tameire, Rani Ojha
Publikováno v:
Nature cell biology, vol 21, iss 7
Nature cell biology
Nature cell biology
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. Here we reveal an essential role
Autor:
Curtis J. Pritzl, Bumsuk Hahm, Adrian B. McDermott, Madhuvanthi Vijayan, Chuan Xia, Serge Y. Fuchs
Publikováno v:
Journal of Virology. 90:2403-2417
Influenza A virus (IAV) employs diverse strategies to circumvent type I interferon (IFN) responses, particularly by inhibiting the synthesis of type I IFNs. However, it is poorly understood if and how IAV regulates the type I IFN receptor (IFNAR)-med
Autor:
Jing Jiang, Jie Xu, Dongmei Sun, Stuart J. Frank, Wen Y. Chen, Yue Zhang, Serge Y. Fuchs, John F. Langenheim, Hao Yu, Deepti Bahl, Luqin Deng
Publikováno v:
Molecular Endocrinology. 27:266-279
GH and prolactin (PRL) are structurally related hormones that exert important effects in disparate target tissues. Their receptors (GHR and PRLR) reside in the cytokine receptor superfamily and share signaling pathways. In humans, GH binds both GHR a
Autor:
Ekaterina Bobrovnikova-Marjon, Dariusz Pytel, Jake A. Kushner, Brian Frederick, Hui Zheng, Constantinos Koumenis, J. Alan Diehl, Nancy L. Maas, Nilesh Chitnis, Lewis A. Chodosh, Dhruv K. Pant, Serge Y. Fuchs
Publikováno v:
Molecular Cell. 48:353-364
MicroRNAs typically function at the level of posttranscriptional gene silencing within the cytoplasm; however, increasing evidence suggests that they may also function in nuclear, Argonaut-containing complexes, to directly repress target gene transcr
Publikováno v:
Journal of Biological Chemistry. 286:35733-35741
Type 1 interferons (including IFNα/β) activate their cell surface receptor to induce the intracellular signal transduction pathways that play an important role in host defenses against infectious agents and tumors. The extent of cellular responses
Autor:
Christos Tzimas, Constantinos Koumenis, Darren P. Baker, J. Alan Diehl, Juan Qian, Sabyasachi Bhattacharya, Serge Y. Fuchs
Publikováno v:
Journal of Biological Chemistry
Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of type I interferon (IFN) receptor is a robust and specific mechanism that limits the magnitude and duration of IFNα/β signaling. Besides the ligand-inducible IFNAR1 degr
Autor:
Sudhakar Veeranki, J. Alan Diehl, Wei Chun HuangFu, Darren P. Baker, Sabyasachi Bhattacharya, Constantinos Koumenis, Serge Y. Fuchs, Jianghuai Liu
Publikováno v:
Journal of Biological Chemistry. 285:2318-2325
Phosphorylation-dependent ubiquitination and ensuing down-regulation and lysosomal degradation of the interferon alpha/beta receptor chain 1 (IFNAR1) of the receptor for Type I interferons play important roles in limiting the cellular responses to th
Autor:
Bentley Varghese, Thai H. Tran, Serge Y. Fuchs, Alexandr Plotnikov, Chengbao Liu, Hallgeir Rui
Publikováno v:
Cancer Research. 69:3165-3172
Signaling by polypeptide hormone prolactin (PRL) is mediated by its cognate receptor (PRLr). PRLr is commonly stabilized in human breast cancer due to decreased phosphorylation of residue Ser349, which when phosphorylated recruits the βTrcp E3 ubiqu
Autor:
Robert B. Hamanaka, Rafael Aldabe, James P. Casey, Christina Grigoriadou, Wei Chun HuangFu, J. Alan Diehl, Serge Y. Fuchs, K.G. Suresh Kumar, Juan Qian, Jianghuai Liu
Publikováno v:
Cell Host & Microbe. 5:72-83
SummaryPhosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of the type I interferon (IFN) receptor is regulated by two different pathways, one of which is ligand independent. We report that this ligand-independent pathway is
Publikováno v:
FEBS Letters. 582:3206-3210
While negative effect of smoking on the resistance to viral infections was known, the underlying mechanisms remained unclear. Here we report that products of cigarette smoking compromise the cellular anti-viral defenses by inhibiting the signaling in