Zobrazeno 1 - 6
of 6
pro vyhledávání: '"M. Miralpeix"'
Publikováno v:
Molecular and Cellular Biology. 13:7418-7428
IRS-1 (insulin receptor substrate 1) is a principal insulin receptor substrate that undergoes tyrosine phosphorylation during insulin stimulation. It contains over 20 potential tyrosine phosphorylation sites, and we suspect that multiple insulin sign
Autor:
C R Kahn, Morris F. White, Xiao Jian Sun, Martin G. Myers, J M Backer, M. Miralpeix, Erin Glasheen
Publikováno v:
Journal of Biological Chemistry. 267:22662-22672
IRS-1 is a major insulin receptor substrate which may play an important role in insulin signal transmission. The mRNA for IRS-1 in rat cells and tissues is about 9.5 kilobases (kb). Rat liver IRS-1 was stably expressed in Chinese hamster ovary (CHO)
Publikováno v:
The Journal of biological chemistry. 267(31)
IRS-1 is a major insulin receptor substrate which may play an important role in insulin signal transmission. The mRNA for IRS-1 in rat cells and tissues is about 9.5 kilobases (kb). Rat liver IRS-1 was stably expressed in Chinese hamster ovary (CHO)
Publikováno v:
The Journal of clinical investigation. 90(5)
Insulin rapidly stimulates tyrosine phosphorylation of a protein of approximately 185 kD in most cell types. This protein, termed insulin receptor substrate-1 (IRS-1), has been implicated in insulin signal transmission based on studies with insulin r
Autor:
Edward Y. Skolnik, Martin G. Myers, M Miralpeix, D J Chin, Patrick J. Hu, Xiao Jian Sun, Jonathan M. Backer, B Margolis, Joseph Schlessinger, Steven E. Shoelson
Publikováno v:
The EMBO journal. 11(9)
IRS-1 undergoes rapid tyrosine phosphorylation during insulin stimulation and forms a stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3'-kinase, but p85 is not tyrosyl phosphorylated. IRS-1 contains nine tyrosi
Publikováno v:
Scopus-Elsevier
The incubation of isolated rat hepatocytes with vanadate increased the concentration of fructose 2,6-bisphosphate without modifying 6-phosphofructo-2-kinase activity. Vanadate also reverted and prevented the decrease of fructose 2,6-bisphosphate leve