Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jiri Bartek"'
Autor:
Jiri Bartek, Lea Milling Korsholm, Yonglun Luo, Oliver Quevedo, Diana A Ahmad, Lin Lin, Ekaterina Dulina, Zita Gál, Dorthe Helena Larsen
Publikováno v:
Nucleic Acids Research
Korsholm, L M, Gál, Z, Lin, L, Quevedo, O, Ahmad, D A, Dulina, E, Luo, Y, Bartek, J & Larsen, D H 2019, ' Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair ', Nucleic Acids Research, vol. 47, no. 15, pp. 8019-8035 . https://doi.org/10.1093/nar/gkz518
Korsholm, L M, Gál, Z, Lin, L, Quevedo, O, Ahmad, D A, Dulina, E, Luo, Y, Bartek, J & Larsen, D H 2019, ' Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair ', Nucleic Acids Research, vol. 47, no. 15, pp. 8019-8035 . https://doi.org/10.1093/nar/gkz518
The nucleolus is a nuclear sub-domain containing the most highly transcribed genes in the genome. Hundreds of human ribosomal RNA (rRNA) genes, located in the nucleolus, rely on constant maintenance. DNA double-strand breaks (DSBs) in rRNA genes acti
Autor:
Patrik, Oleksak, Miroslav, Psotka, Marketa, Vancurova, Olena, Sapega, Jana, Bieblova, Milan, Reinis, David, Rysanek, Romana, Mikyskova, Katarina, Chalupova, David, Malinak, Jana, Svobodova, Rudolf, Andrys, Helena, Rehulkova, Vojtech, Skopek, Pham, Ngoc Lam, Jiri, Bartek, Zdenek, Hodny, Kamil, Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Autor:
David Malinak, Pham Ngoc Lam, Marketa Vancurova, Romana Mikyšková, Vojtech Skopek, Kamil Musilek, Jana Svobodova, Helena Rehulkova, Zdenek Hodny, Miroslav Psotka, Milan Reinis, Olena Sapega, Jiri Bartek, Katarina Chalupova, Rudolf Andrys, David Rysanek, Patrik Oleksak, Jana Bieblová
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cac5c92173998608c522cc3e9dc3be
Autor:
Hisao Masai, Jiri Bartek, Mayumi Shindo, Masayuki Yamada, Sayuri Ito, Hidemasa Goto, Masaki Inagaki, Gaik Theng Toh, Kozo Tanaka, Kinue Kuniyasu, Masaaki Sawa
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
The conserved serine-threonine kinase, Cdc7, plays a crucial role in initiation of DNA replication by facilitating the assembly of an initiation complex. Cdc7 is expressed at a high level and exhibits significant kinase activity not only during S-pha
Autor:
Jan Svadlenka, Hana Hanzlikova, Libor Macurek, Zdenek Hodny, Jan Brazina, Ladislav Andera, Jiri Bartek
Publikováno v:
Cell Cycle. 14:375-387
Death domain-associated protein 6 (DAXX) is a histone chaperone, putative regulator of apoptosis and transcription, and candidate modulator of p53-mediated gene expression following DNA damage. DAXX becomes phosphorylated upon DNA damage, however reg
Autor:
Paul A. Townsend, Daniel Schramek, Josef M. Penninger, Athanassios Kotsinas, Jiri Bartek, Panagiota Papanagnou, Vassilis G. Gorgoulis, Panagiotis Galanos
Publikováno v:
Cell Cycle. 13:1227-1236
Sensing, integrating, and processing of stressogenic signals must be followed by accurate differential response(s) for a cell to survive and avoid malignant transformation. The DNA damage response (DDR) pathway is vital in this process, as it deals w
Autor:
Jiri Bartek, Vyacheslav Akimov, Luis I. Toledo, Claudia Lukas, Maj-Britt Rask, Matthias Altmeyer, Thorkell Gudjonsson, Jiri Lukas, Blagoy Blagoev, Merete Grøfte
Publikováno v:
Altmeyer, M F, Toledo, L, Gudjonsson, T, Grøfte, M, Rask, M-B, Lukas, C, Akimov, V, Blagoev, B, Bartek, J & Lukas, J 2013, ' The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling ', Molecular Cell, vol. 52, no. 2, pp. 206-220 . https://doi.org/10.1016/j.molcel.2013.08.025
Although the general relevance of chromatin modifications for genotoxic stress signaling, cell-cycle checkpoint activation, and DNA repair is well established, how these modifications reach initial thresholds in order to trigger robust responses rema
Autor:
Vassilis Zoumpourlis, Jiri Bartek, Thanos D. Halazonetis, Ayguel Dereli-Oz, Wei Gu, Jirina Bartkova, Sladana Bursac, Siniša Volarević, Theodoros I. Roumeliotis, Apostolos Klinakis, Dimitris Kletsas, Kostas Evangelou, Georgia Velimezi, Maria Sideridou, Maja Cokaric-Brdovcak, Athanassios Kotsinas, Michalis Liontos, Vassilis G. Gorgoulis, Konstantinos Vougas, Ioannis S. Pateras, Maciej K. Kocylowski, Ines Orsolic, George Papafotiou
Publikováno v:
Nature cell biology
The DNA damage response (DDR) pathway and ARF function as barriers to cancer development. Although commonly regarded as operating independently of each other, some studies proposed that ARF is positively regulated by the DDR. Contrary to either scena
Autor:
Jiri Bartek, Martin V. Bennetzen, Jiri Lukas, Dorthe Helena Larsen, Jens S. Andersen, Jakob Bunkenborg
Publikováno v:
Bennetzen, M, Larsen, D H, Bunkenborg, J, Bartek, J, Lukas, J & Andersen, J S 2010, ' Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response ', Molecular and Cellular Proteomics, vol. 9, no. 6, pp. 1314-1323 . https://doi.org/10.1074/mcp.M900616-MCP200
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics; Vol 9
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics; Vol 9
To investigate the temporal regulation of the DNA damage response, we applied quantitative mass spectrometry-based proteomics to measure site-specific phosphorylation changes of nuclear proteins after ionizing radiation. We profiled 5204 phosphorylat
Autor:
Christian T. Carson, Darwin V. Lee, Jiri Lukas, Matthew D. Weitzman, Nicole I. Orazio, Seema S. Lakdawala, Caroline E. Lilley, Jiri Bartek, Junghae Suh, Felipe D. Araujo, Simon Bekker-Jensen
Publikováno v:
The EMBO Journal. 28:652-662
The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA