Zobrazeno 41 - 50
of 62
pro vyhledávání: '"Jiri Bartek"'
Autor:
Claudia Lukas, Jiri Bartek, Simon Bekker-Jensen, David C. Schultz, Yosef Shiloh, Yaron Galanty, Yael Ziv, Jiri Lukas, Yoichi Taya, Dana Bielopolski
Publikováno v:
Nature cell biology. 8(8)
The cellular DNA-damage response is a signaling network that is vigorously activated by cytotoxic DNA lesions, such as double-strand breaks (DSBs)1. The DSB response is mobilized by the nuclear protein kinase ATM, which modulates this process by phos
Publikováno v:
University of Copenhagen
The ATR and Chk1 kinases are essential to maintain genomic integrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex, activates Chk1 after DNA damage. Chk1-mediated phosphorylation of the Cdc25A phosphatase is required for the mammalian S-phase che
Autor:
Christopher J. Bakkenist, Zuzana Horejsi, Jiri Bartek, Jiri Lukas, Jacob Falck, Michael B. Kastan
Publikováno v:
Oncogene. 23(17)
The ATM kinase is a tumour suppressor and a key activator of genome integrity checkpoints in mammalian cells exposed to ionizing radiation (IR) and other insults that elicit DNA double-strand breaks (DSBs). In response to IR, autophosphorylation on s
Publikováno v:
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 147(1)
Intracellular levels of phosphorylation are regulated by the coordinated action of protein kinases and phosphatases. Disregulation of this balance can lead to cellular transformation. Here we review knowledge of the mechanisms of one protein phosphat
Autor:
Scott Vuocolo, Enhksetseg Purev, Dianne Robert Soprano, Kenneth J. Soprano, Dongmei Zhang, Jiri Bartek, Klaus Hansen
Publikováno v:
The Journal of biological chemistry. 278(43)
Levels of Rb2/p130 protein are increased 5-10-fold following all-trans-retinoic acid (ATRA) treatment of the retinoid-sensitive ovarian adenocarcinoma cell line CAOV3, but not the retinoid-resistant adenocarcinoma cell line SKOV3. We found that this
Publikováno v:
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 111(1)
Deregulated cell cycle and defective genome-integrity checkpoints are among the hallmarks of cancer. Here we summarize our recent studies of key components of the Gl/S machinery in normal human spermatogenesis, and their abnormalities in testicular g
Autor:
Jirina, Bartkova, Claudia, Lukas, Claus S, Sørensen, Ewa, Rajpert-De Meyts, Niels E, Skakkebaek, Jiri, Lukas, Jiri, Bartek
Publikováno v:
The Journal of pathology. 200(2)
Deregulation of the RB pathway is shared by most human malignancies. Components upstream of the retinoblastoma tumour suppressor (pRB), namely the INK4 family of cyclin-dependent kinase (CDK) inhibitors, the D-type cyclins, their partner kinases CDK4
Autor:
Jiri Bartek, Erich A. Nigg, Klaus Hansen, Anja Groth, Jiri Lukas, Christer Wernstedt, Herman H W Silljé
Publikováno v:
The EMBO journal. 22(7)
All eukaryotes respond to DNA damage by modulation of diverse cellular processes to preserve genomic integrity and ensure survival. Here we identify mammalian Tousled like kinases (Tlks) as a novel target of the DNA damage checkpoint. During S-phase
Autor:
Stephen P. Jackson, Darryl J. Pappin, Michal Goldberg, Jiri Bartek, Manuel Stucki, Jacob Falck, Damien D’Amours, Dinah Rahman
Publikováno v:
Nature. 421(6926)
MRE11, RAD50 and NBS1 form a highly conserved protein complex (the MRE11 complex) that is involved in the detection, signalling and repair of DNA damage. We identify MDC1 (KIAA0170/NFBD1), a protein that contains a forkhead-associated (FHA) domain an
Publikováno v:
Nature cell biology. 5(3)
Cell cycle checkpoints are signal transduction pathways activated after DNA damage to protect genomic integrity. Dynamic spatiotemporal coordination is a vital, but poorly understood aspect, of these checkpoints. Here, we provide evidence for a strik