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pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Alma F. Ferrier, Douglas R. Lowy, Giovanna Benvenuto, Deborah K. Morrison, Jeffrey E. DeClue, Wayne B. Anderson, Michael Lee
Publikováno v:
Journal of Biological Chemistry. 272:2136-2142
The Raf-1 serine/threonine protein kinase plays a central role in many of the mitogenic signaling pathways regulating cell growth and differentiation. The regulation of Raf-1 is complex, and involves protein-protein interactions as well as changes in
Autor:
Shaowei Li, Jeremy Peter Cheadle, Julie Helen Maynard, Lee Parry, Angela Hodges, Julian R. Sampson, Jeffrey E. DeClue, Richard Braverman
Publikováno v:
Human molecular genetics. 10(25)
Critical functions of hamartin and tuberin, encoded by the TSC1 and TSC2 genes, are likely to be closely linked. The proteins interact directly with one another and mutations affecting either gene result in the tuberous sclerosis phenotype. However,
Publikováno v:
Trends in genetics : TIG. 7(11-12)
The ras genes encode GTP/GDP-binding proteins that participate in mediating mitogenic signals from membrane tyrosine kinases to downstream targets. The activity of p21ras is determined by the concentration of GTP-p21ras, which is tightly regulated by
Overexpression of the full-length GTPase-activating protein (GAP) has recently been shown to suppress c-ras transformation of NIH 3T3 cells but not v-ras transformation (36). Here, we show that focus formation induced by c-src was inhibited by approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9770ff3faf43506b7a378165654164
https://europepmc.org/articles/PMC360064/
https://europepmc.org/articles/PMC360064/
Publikováno v:
Cell. 40:609-618
The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation o