Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dawang Zhou"'
Autor:
Sixian Qi, Yuwen Zhu, Xincheng Liu, Pengyue Li, Yebin Wang, Yan Zeng, Aijuan Yu, Yu Wang, Zhao Sha, Zhenxing Zhong, Rui Zhu, Haixin Yuan, Dan Ye, Shenglin Huang, Chen Ling, Yanhui Xu, Dawang Zhou, Lei Zhang, Fa-Xing Yu
Publikováno v:
Molecular cell. 82(10)
YAP and TAZ (YAP/TAZ), two major effectors of the Hippo signaling pathway, are frequently activated in human cancers. The activity of YAP/TAZ is strictly repressed upon phosphorylation by LATS1/2 tumor suppressors. However, it is unclear how LATS1/2
Autor:
Dawang Zhou, Hong-Rui Wang, Mingdong Liu, Hui Xia, Taoling Zeng, Hong-Lin Chan, Liping Xie, Changchuan Xie, Chunyan Liu, Xin Zhang, Xianming Deng, Tong Jin Zhao, Luming Yao, Zhihui Wu, Qi Lin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
DNA damage can induce autophagy; however, the underlying mechanism remains largely unknown. Here we report that DNA damage leads to autophagy through ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition. DNA da
Publikováno v:
Acta Biochimica et Biophysica Sinica. 47:46-52
The Hippo signaling pathway is an evolutionarily conserved signaling module that plays critical roles in liver size control and tumorigenesis. The Hippo pathway consists of a core kinase cascade in which the mammalian Ste20-like kinases (Mst1/2, orth
Autor:
Dawang Zhou, Qingxu Liu, Shihao Zhang, Qiao Wu, Li Wang, Cong Wang, Changchuan Xie, Cheng Nian, Yuxi Li, Zhenyu Yin, Ying He, Chen Xiao, Jiaxin Li, Fen Wang, Weiji Zhang, Lixin Hong, Lanfen Chen, Qinghua Chen, Junhong Li, Randy L. Johnson, Suyuan Ji, Jing Geng, Han You, Chundong Yu, Kwang Huei Lin, Xing Chen, Xun Li
Publikováno v:
Developmental Cell. 48:460-474.e9
Summary The external factors that modulate Hippo signaling remain elusive. Here, we report that FGF15 activates Hippo signaling to suppress bile acid metabolism, liver overgrowth, and tumorigenesis. FGF15 is induced by FXR in ileal enterocytes in res
Autor:
Siyang Song, Jing Tian, Xianming Deng, Fan Fuqin, Ting Zhang, Changnan Jin, Zhen-Yu Yin, Shihao Zhang, Hongtan Wu, Sheng-Cai Lin, Xiufeng Sun, Dawang Zhou, Suyuan Ji, Jing Geng, Fernando D. Camargo, Funiu Qin, Yang Li, Lianzhong Luo, Luyao Wei, Jianjun Lin, Lanfen Chen, Joseph Avruch, Yubo Xiao
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1663-1677 (2013)
SummaryThe transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds
Publikováno v:
Cell Cycle. 11:1090-1096
The transcriptional co-activator YAP is an evolutionarily conserved regulator of organ size and progenitor cell proliferation. YAP is overexpressed at high frequency in many common human cancers and can directly drive cancer development in mouse mode
Publikováno v:
The Journal of Experimental Medicine
In mice lacking both Mst1 and Mst2 in the lymphoid compartment, thymocyte development is normal, but single-positive thymocytes exhibit excessive apoptosis and greatly diminished thymic egress, accompanied by loss of chemokine activation of RhoA and
Autor:
Joseph Avruch, Dawang Zhou, Fan Xia, Jeannie T. Lee, Yi Yin, Nabeel Bardeesy, Ji Sun Park, Wolfgang Thasler, Claudius Conrad, Gregory Y. Lauwers, Bernhard Payer
Publikováno v:
Cancer Cell. 16(5):425-438
SummaryHippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are cleaved and constitutively activated in the mouse liver. Combined Mst1/
Autor:
Matthew Liu, Benjamin D. Medoff, Joseph Avruch, Lequn Li, Dawang Zhou, Maria Praskova, Ramnik J. Xavier, Xian-feng Zhang, Richard S. Blumberg, Lanfen Chen, Vassiliki A. Boussiotis, Aimee Landry
Publikováno v:
Proceedings of the National Academy of Sciences. 105:20321-20326
The Mst1 and Mst2 protein kinases are the mammalian homologs of hippo, a major inhibitor of cell proliferation in Drosophila. Mst1 is most abundant in lymphoid tissues. Mice lacking Mst1 exhibit markedly reduced levels of the Mst1 regulatory protein
Autor:
Dawang Zhou, Luciano D'Adamio, Gabriella Fulcoli, Chiara D'Ambrosio, Simona Arena, Meir H. Scheinfeld, Andrea Scaloni
Publikováno v:
1st Congress of the Italian Proteomic Association, Pisa, 2006
info:cnr-pdr/source/autori:D'Ambrosio C., Arena S., Fulcoli G., Scheinfeld M.H., Zhou D., D'Adamio L. and Scaloni A./congresso_nome:1st Congress of the Italian Proteomic Association/congresso_luogo:Pisa/congresso_data:2006/anno:2006/pagina_da:/pagina_a:/intervallo_pagine
Molecular & cellular proteomics 5 (2006): 97–113. doi:10.1074/mcp.M500226-MCP200
info:cnr-pdr/source/autori:D'Ambrosio C; Arena S; Fulcoli G; Scheinfeld MH; Zhou D; D'Adamio L; Scaloni A/titolo:Hyperphosphorylation of jnk-interacting protein 1, a protein associated with Alzheimer disease/doi:10.1074%2Fmcp.M500226-MCP200/rivista:Molecular & cellular proteomics/anno:2006/pagina_da:97/pagina_a:113/intervallo_pagine:97–113/volume:5
info:cnr-pdr/source/autori:D'Ambrosio C., Arena S., Fulcoli G., Scheinfeld M.H., Zhou D., D'Adamio L. and Scaloni A./congresso_nome:1st Congress of the Italian Proteomic Association/congresso_luogo:Pisa/congresso_data:2006/anno:2006/pagina_da:/pagina_a:/intervallo_pagine
Molecular & cellular proteomics 5 (2006): 97–113. doi:10.1074/mcp.M500226-MCP200
info:cnr-pdr/source/autori:D'Ambrosio C; Arena S; Fulcoli G; Scheinfeld MH; Zhou D; D'Adamio L; Scaloni A/titolo:Hyperphosphorylation of jnk-interacting protein 1, a protein associated with Alzheimer disease/doi:10.1074%2Fmcp.M500226-MCP200/rivista:Molecular & cellular proteomics/anno:2006/pagina_da:97/pagina_a:113/intervallo_pagine:97–113/volume:5
The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases are activated by pleiotropic signals including environmental stresses, growth factors, and hormones. JNK-interacting protein 1 (JIP1) is a scaffold protein that assemb