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Akademický článek
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Autor:
Albert Lee, Stephanie L. Rayner, Alana De Luca, Serene S. L. Gwee, Marco Morsch, Vinod Sundaramoorthy, Hamideh Shahheydari, Audrey Ragagnin, Bingyang Shi, Shu Yang, Kelly L. Williams, Emily K. Don, Adam K. Walker, Katharine Y. Zhang, Justin J. Yerbury, Nicholas J. Cole, Julie D. Atkin, Ian P. Blair, Mark P. Molloy, Roger S. Chung
Publikováno v:
Open Biology, Vol 7, Iss 10 (2017)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3–5 years of diagnosis. Recently, we identified disease-linke
Externí odkaz:
https://doaj.org/article/de64dd65912e44579c028274a46fd196
Akademický článek
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Publikováno v:
Circulation Research. 125
Background/hypothesis: Heart failure (HF) afflicts 6.2M Americans as of 2019 and its prevalence is expected to increase due to a growing aging population. HF progression involves depression in contractility and relaxation, which are strongly controll
Autor:
Katharine Y. Zhang, Alana De Luca, Bingyang Shi, Adam K. Walker, Justin J. Yerbury, Julie D. Atkin, Marco Morsch, Kelly L. Williams, Stephanie L. Rayner, Shu Yang, Albert Lee, Roger S. Chung, Mark P. Molloy, Hamideh Shahheydari, Ian P. Blair, Vinod Sundaramoorthy, Nicholas J. Cole, Audrey Ragagnin, Serene S. L. Gwee, Emily K. Don
Publikováno v:
Open Biology
Open Biology, Vol 7, Iss 10 (2017)
Open Biology, Vol 7, Iss 10 (2017)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3–5 years of diagnosis. Recently, we identified disease-linke
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Robert Hayward, Cam Patterson, Kathryn Mercer, Richard Marais, Susan Giblett, Catrin Pritchard, Jahan Hussain, Catherine Noble, Linda A. S. Carragher
Publikováno v:
Molecular Cell. 31(6):862-872
The CRAF protein kinase regulates proliferative, differentiation, and survival signals from activated RAS proteins to downstream effectors, most often by inducing MEK/ERK activation. A well-established model of CRAF regulation involves RAS-mediated t
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Biological Chemistry. 279:30573-30578
The cellular target responsible for the nuclear export of Daxx has been identified as chromosomal region maintenance 1 (CRM1), which is a carrier protein for nuclear export and a receptor for the nuclear export signal (NES) of Daxx. Binding of Daxx t
Autor:
Alma F. Ferrier, Douglas R. Lowy, Giovanna Benvenuto, Deborah K. Morrison, Jeffrey E. DeClue, Wayne B. Anderson, Michael Lee
Publikováno v:
Journal of Biological Chemistry. 272:2136-2142
The Raf-1 serine/threonine protein kinase plays a central role in many of the mitogenic signaling pathways regulating cell growth and differentiation. The regulation of Raf-1 is complex, and involves protein-protein interactions as well as changes in
Autor:
Petra Janosch, A. Philipp, T Seitz, Walter Kolch, Harald Mischak, M Schellerer, Helge Steen, Manfred Eulitz
Publikováno v:
Scopus-Elsevier
The elevation of cyclic AMP (cAMP) levels in the cell downregulates the activity of the Raf-1 kinase. It has been suggested that this effect is due to the activation of cAMP-dependent protein kinase (PKA), which can directly phosphorylate Raf-1 in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0accc2a5994c19c46cc906a268b51eb
https://europepmc.org/articles/PMC231540/
https://europepmc.org/articles/PMC231540/