Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Navya Shilpa Josyula"'
Autor:
Sudin Bhattacharya, Timothy R. Zacharewski, Norbert E. Kaminski, Edward Dere, Melvin E. Andersen, Navya Shilpa Josyula
Publikováno v:
Archives of Toxicology. 94:113-126
Four decades after its discovery, the aryl hydrocarbon receptor (AHR), a ligand-inducible transcription factor (TF) activated by the persistent environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), remains an enigmatic molecule with a
Autor:
Manuel A. R. Ferreira, Ali Naji, Todd L. Edwards, Anne E. Justice, Marylyn D. Ritchie, John D. Overton, Theodore G. Drivas, Nathan Katz, Ying H. Shen, Yanming Li, Renae Judy, Anastasia Lucas, Amanda Dobbyn, Anurag Verma, Scott M. Damrauer, Daniel J. Rader, Geetha Chittoor, Maria Fasolino, Xinyuan Zhang, Jinbo Chen, Scott A. LeMaire, Alexander H. Li, Joseph H. Breeyear, Rachel L. Kember, Kumardeep Chaudhary, Joseph Park, JoEllen Weaver, Shadi Ahmadmehrabi, Alan Daugherty, Hisashi Sawada, Yuki Bradford, Klaus H. Kaestner, Jeffrey G. Reid, Ron Do, Navya Shilpa Josyula, Golnaz Vahedi, Girish N. Nadkarni, Judy H. Cho, Chen Zhang, Aris Baras, Venkata R M Chavali
Publikováno v:
Nat Med
The clinical impact of rare loss-of-function variants has yet to be determined for most genes. Integration of DNA sequencing data with electronic health records (EHRs) could enhance our understanding of the contribution of rare genetic variation to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a14e815fc8981dcb22592d74596aad7
https://europepmc.org/articles/PMC8775355/
https://europepmc.org/articles/PMC8775355/
Autor:
Ky’Era Actkins, Kevin Ho, Gail P. Jarvik, Brody Holohan, Felix R. Day, Navya Shilpa Josyula, Yanfei Zhang, Hakon Hakonarson, Sarah A. Pendergrass, Digna R. Velez Edwards, Ming Ta Michael Lee, Jacob M. Keaton, Dustin N. Hartzel, David R. Crosslin, Patrick M. A. Sleiman, Lea K. Davis, Marc S. Williams, Anne E. Justice, Andrea H. Ramirez, Ian B. Stanaway
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. Previous studies have identified genetic variants associated with PCOS identified by different diagnostic criteria. The Rotterdam Cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b5dbbd75a0b3144f975140a493278d
https://doi.org/10.1101/2019.12.12.19014761
https://doi.org/10.1101/2019.12.12.19014761
Autor:
Joseph B. Leader, Marylyn D. Ritchie, Sarah A. Pendergrass, Yu Zhang, Anastasia Lucas, Anqa Khan, Dustin N. Hartzel, Shefali S. Verma, Daniel R. Lavage, Anurag Verma, Navya Shilpa Josyula
Publikováno v:
The American Journal of Human Genetics. 102:592-608
Most phenome-wide association studies (PheWASs) to date have used a small to moderate number of SNPs for association with phenotypic data. We performed a large-scale single-cohort PheWAS, using electronic health record (EHR)-derived case-control stat
Autor:
Diego R. Mazzotti, Allan I. Pack, Sarah A. Pendergrass, Navya Shilpa Josyula, Brendan T. Keenan, Christopher R. Bauer, Beth A. Malow, Janet D. Robishaw, Olivia J. Veatch, Kanika Bagai
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
Background Obstructive sleep apnea (OSA) is defined by frequent episodes of reduced or complete cessation of airflow during sleep and is linked to negative health outcomes. Understanding the genetic factors influencing expression of OSA may lead to n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd9599d928809239d82a2ecc223e101
Autor:
Xinyuan Zhang, Frederick E. Dewey, Navya Shilpa Josyula, Dustin N. Hartzel, Shefali S. Verma, Daniel R. Lavage, Sarah A. Pendergrass, Joe Leader, Anurag Verma, Yogasudha Veturi, Marylyn D. Ritchie
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential to mimic the effect of dru