Zobrazeno 1 - 10
of 25
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Renate Lüllmann-Rauch, Markus Damme, Annika Ericsson, Judith Blanz, Paul Saftig, Michelle Rothaug, Rudi D'Hooge, Claes Andersson, Jens Fogh, Hans Christian Beck, Meike Lüdemann, Stijn Stroobants
Publikováno v:
Damme, M, Stroobants, S, Lüdemann, M, Rothaug, M, Lüllmann-Rauch, R, Beck, H C, Ericsson, A, Andersson, C, Fogh, J, D’Hooge, R, Saftig, P & Blanz, J 2015, ' Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice ', Annals of Clinical and Translational Neurology, vol. 2, no. 11, pp. 987-1001 . https://doi.org/10.1002/acn3.245
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
OBJECTIVE: The lysosomal storage disease alpha-mannosidosis is caused by the deficiency of the lysosomal acid hydrolase alpha-mannosidase (LAMAN) leading to lysosomal accumulation of neutral mannose-linked oligosaccharides throughout the body, includ
Autor:
Rudi D'Hooge, Cecilia Weigelt, Volkmar Gieselmann, Claes Andersson, Carl Eistrup, Ulrich Matzner, Jens Fogh, Renate Lüllmann-Rauch, Stijn Stroobants
Publikováno v:
Molecular Therapy. 17(4):600-606
Inherited deficiencies of lysosomal hydrolases cause lysosomal storage diseases (LSDs) that are characterized by a progressive multisystemic pathology and premature death. Repeated intravenous injection of the active counterpart of the deficient enzy
Autor:
Hans Bockhardt, Renate Lüllmann-Rauch
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:45-48
This study was aimed at the question of whether or not the antidepressant zimelidine, which is an amphiphilic cationic compound, can induce generalized lipidosis in animals. Rats were chronically treated with high oral doses (80 mg/kg) of the drug, a
Publikováno v:
General Pharmacology: The Vascular System. 27:1317-1324
1. Certain compounds (e.g., the immunomodulator tilorone and congeners) are able to induce lysosomal storage of sulphated glycosaminoglycans (GAG), thus, producing cytological and biochemical alterations reminiscent of the inherited mucopolysaccharid
Publikováno v:
Pharmacology & Toxicology. 79:109-113
The immunomodulatory drug tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one) and several congeners are known to disturb the lysosomal degradation of sulphated glycosaminoglycans and thereby induce lysosomal storage of glycosaminoglycans in cultu
Publikováno v:
Archives of Toxicology. 64:291-298
The purpose of the present investigation was to establish a cell culture system suitable for demonstrating the drug-induced lysosomal storage of sulfated glycosaminoglycans (GAGs). This is a drug side-effect which was previously studied in animals tr
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t
Publikováno v:
Biochemical pharmacology. 49(9)
This investigation deals with a drug side-effect. The immunomodulatory drug tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one) and congeners induce lysosomal storage of sulphated glycosaminoglycans (GAGs) in animals and in cultured cells. At hig
Publikováno v:
Toxicology and applied pharmacology. 114(2)
The purpose of the present cytological and radiochemical study was to investigate whether the immunomodulatory agent 3,6-bis[2-(diethylamino)ethoxy]acridine (CL-90.100) and three congeners induce lysosomal storage of sulfated glycosaminoglycans (sGAG
Publikováno v:
Toxicology and applied pharmacology. 114(2)
In the accompanying paper, four dibasic acridine derivatives were reported to induce lysosomal storage of sulfated glycosaminoglycans (sGAG), i.e., mucopolysaccharidosis, in cultured fibroblast (Handrock et al. Toxicol. Appl. Pharmacol. 114, 1992). T