Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Zhuorong Li"'
Publikováno v:
Frontiers in Pharmacology. 14
Neurodegenerative diseases (NDs) are common chronic disorders associated with progressive nervous system damage, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, among others. Mitochondria are abundant in various ne
Publikováno v:
Future Medicinal Chemistry. 14:207-219
Aim: Given the importance of FOXM1 in the treatment of ovarian cancer, we aimed to identify an excellent specific inhibitor and examined its underlying therapeutic effect. Materials & methods: The binding statistics for FDI-6 with FOXM1 were calculat
Publikováno v:
Microbial Drug Resistance. 27:933-941
Polymyxin B and colistin (polymyxin E) are increasingly used as the last line of therapy for infections caused by multidrug-resistant (MDR) gram-negative pathogens. However, nephrotoxicity is still...
Autor:
Yan Gao, Jing Geng, Zhuosong Xie, Ziying Zhou, Hexian Yang, Hong Yi, Xiaoyang Han, Situ Xue, Zhuorong Li
Publikováno v:
European journal of medicinal chemistry. 244
FOXM1 signalling pathways are highly expressed in multiple human cancers. Based on the crystal structure of the FOXM1 DNA binding domain, our preliminary research found ethylene glycol (4-benzyloxyphenyl) cyclopentylaminoethyl ether XST20, which coul
Autor:
Si-tu Xue, Yu-Huan Li, Zhao-Jin Zhong, Shuo Wu, A-Long Cui, Zhuorong Li, Jie Jin, Wen-Fang Sun
Publikováno v:
Drug Design, Development and Therapy. 14:3723-3729
Introduction Hepatitis B virus (HBV) is a global health concern that can cause acute and chronic liver diseases. Thus, there is an urgent need to research novel anti-HBV agents. Our previous reports show that N-phenylbenzamide derivatives exert broad
The Research Topic “Novel Therapeutic Target and Drug Discovery for Neurological Diseases” consists of 20 articles, including 12 original research papers, seven reviews, and one systematic review, with contributions from more than 140 authors. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3414819f764663ac1bd6e87ea647c1ef
Publikováno v:
Pharmacological research. 178
Alzheimer's disease (AD) pathogenesis is known to involve a dysregulation of microRNA expression, and these intricate transcriptional cascades between multiple pathological manifestations affect brain homeostasis. Previous studies have revealed that
Autor:
Mimin Liu, Guangzhi Shan, Hailun Jiang, Li Zeng, Kaiyue Zhao, Yiran Li, Ghulam Md Ashraf, Zhuorong Li, Rui Liu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Vascular dementia (VaD) is a general term used to describe difficulties in memory, reasoning, judgment, and planning caused by a reduced blood flow to the brain and consequent brain damage, in which microRNAs (miRNAs) are involved. Dracocephalum mold
Autor:
Zhuorong Li, Xingyue Ji
Publikováno v:
Medicinal Research Reviews
Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic. However, DAAs suffer from several inherent limitations, including na
Publikováno v:
Future Medicinal Chemistry. 11:2877-2890
Aim: An urgent need for the development of antibiotics with novel structures and unexploited targets. Materials & methods: Racemic chuangxinmycin was obtained via a novel synthesis route. Chiral preparative chromatography was used to separate chuangx