Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Yuji Ikegaya"'
Publikováno v:
Journal of Pharmacological Sciences. 152:136-143
Publikováno v:
Journal of Pharmacological Sciences. 152:128-135
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:789-797
Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a melatonin MT1/MT2 receptor agonist, h
Autor:
Toshihiko Yanagita, Yuji Ikegaya
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 157(2)
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 97-104 (2021)
Sleep disorders adversely affect daily activities and cause physiological and psychiatric problems. The shortcomings of benzodiazepine hypnotics have led to the development of ramelteon, a melatonin MT1 and MT2 agonist. Although the sleep-promoting e
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 4, Pp 212-217 (2020)
The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are exce
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1356-1360
Polyherbal medicines are composed of multiple herbs and have traditionally been used in East Asian countries for the remedy of physiological symptoms. Although the effects of polyherbal formulations have been investigated at the molecular and behavio
Publikováno v:
Neuropsychopharmacology Reports
Aim Organotypic brain slice culture preserves the geographical position of neurons and neuronal circuits. The slice cultures also maintain both non‐neuronal cell types and the surrounding extracellular matrix. The interface method has been widely u
Publikováno v:
Neuropsychopharmacology Reports
Background Status epilepticus‐induced hippocampal neuronal death, astrogliosis, and the activation of microglia are common pathological changes in mesial temporal lobe epilepsy (mTLE) with resistance to antiepileptic drugs. Neuronal death in mTLE g
Publikováno v:
Neuropsychopharmacology Reports
Aim The accumulation of amyloid beta (Aβ) is one of the characteristics of Alzheimer's disease. The excessive accumulation of Aβ has been suggested to result in a decrease in the number of synapses. Although the number of synapses is generally modu