Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Riccardo Brambilla"'
Autor:
Gerard W. O'Keeffe, Nurulain T. Zaveri, Ilaria Morella, Daniela Mercatelli, Martina Mazzocchi, Riccardo Brambilla, Michele Morari, Alberto Brugnoli, Stefania Fasano, Richard R. Neubig, Clarissa Anna Pisanò
Background and purpose Regulator of G-protein signal 4 (RGS4) is a signal transduction protein that accelerates intrinsic GTPase activity of Gαi/o and Gαq subunits, suppressing GPCR signaling. Here we investigate whether RGS4 modulates nociceptin/o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a564af83ffb46926abc647c19aea84b
https://hdl.handle.net/11392/2472868
https://hdl.handle.net/11392/2472868
Autor:
Ilaria, Morella, Veronika, Pohořalá, Claudia, Calpe-López, Riccardo, Brambilla, Rainer, Spanagel, Rick E, Bernardi
Publikováno v:
Frontiers in Pharmacology
Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in nicotine-related reward behaviors. We examined the role of Ras Guanine Nuc
Autor:
Stefania Fasano, Nurulain T. Zaveri, Martina Frassineti, Ludovico Arcuri, Clarissa Anna Pisanò, Michele Morari, Willma E. Polgar, Riccardo Brambilla, Michael E Meyer, Ilaria Morella, Daniela Mercatelli, V. Blair Journigan, Salvatore Novello
Publikováno v:
British Journal of Pharmacology. 175:782-796
Background and Purpose We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa-induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two nov
Autor:
Riccardo Brambilla, Stefania Fasano, Ilaria Morella, Anastasia Olevska, Rick E. Bernardi, Rainer Spanagel, Eugenio Santos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Copyright © 2019 the authors.
Ras/Raf/MEK/ERK (Ras-ERK) signaling has been implicated in the effects of drugs of abuse. Inhibitors of MEK1/2, the kinases upstream of ERK1/2, have been critical in defining the role of the Ras-ERK cascade in drug
Ras/Raf/MEK/ERK (Ras-ERK) signaling has been implicated in the effects of drugs of abuse. Inhibitors of MEK1/2, the kinases upstream of ERK1/2, have been critical in defining the role of the Ras-ERK cascade in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79445a74526bc8778cc651c96866826
http://hdl.handle.net/10261/203950
http://hdl.handle.net/10261/203950
Autor:
Michela Rosas, Alessandra Tiziana Peana, Gaetano Di Chiara, Sandro Fenu, Riccardo Brambilla, Elio Maria Gioachino Acquas, Alessandro Papale, Stefania Ruiu, Simona Porru
Publikováno v:
Psychopharmacologia 233 (2016): 2943–2954. doi:10.1007/s00213-016-4340-8
info:cnr-pdr/source/autori:Rosas M.; Porru S.; Fenu S.; Ruiu S.; Peana A.T.; Papale A.; Brambilla R.; Di Chiara G.; Acquas E./titolo:Role of nucleus accumbens ? opioid receptors in the effects of morphine on ERK1%2F2 phosphorylation/doi:10.1007%2Fs00213-016-4340-8/rivista:Psychopharmacologia/anno:2016/pagina_da:2943/pagina_a:2954/intervallo_pagine:2943–2954/volume:233
info:cnr-pdr/source/autori:Rosas M.; Porru S.; Fenu S.; Ruiu S.; Peana A.T.; Papale A.; Brambilla R.; Di Chiara G.; Acquas E./titolo:Role of nucleus accumbens ? opioid receptors in the effects of morphine on ERK1%2F2 phosphorylation/doi:10.1007%2Fs00213-016-4340-8/rivista:Psychopharmacologia/anno:2016/pagina_da:2943/pagina_a:2954/intervallo_pagine:2943–2954/volume:233
Rationale: Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK phosphorylation in this area are still con
Autor:
Ludovico, Arcuri, Salvatore, Novello, Martina, Frassineti, Daniela, Mercatelli, Clarissa Anna, Pisanò, Ilaria, Morella, Stefania, Fasano, Blair V, Journigan, Michael E, Meyer, Willma E, Polgar, Riccardo, Brambilla, Nurulain T, Zaveri, Michele, Morari
BACKGROUND AND PURPOSE: We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa‐induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::661fab0bfa9e8a543cc5a8bfaebd82aa
Autor:
Rosario Moratalla, Stefania Fasano, Riccardo Brambilla, Irene Ruiz-DeDiego, Jose Ruben Garcia-Montes, Oscar Solís, José Brea, María Isabel Loza
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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Scientific Reports
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Increasing evidence supports a close relationship between Ras-ERK1/2 activation in the striatum and L-DOPA-induced dyskinesia (LID). ERK1/2 activation by L-DOPA takes place through the crosstalk between D1R/AC/PKA/DARPP-32 pathway and NMDA/Ras pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ada8cf35aff7dfa94df96aeb87458b
https://hdl.handle.net/10347/22624
https://hdl.handle.net/10347/22624
Autor:
Stefania Fasano, Simone Bido, Marzia Indrigo, Angela D'Antoni, Michele Morari, Nicola Solari, Riccardo Brambilla
Publikováno v:
Annals of Clinical and Translational Neurology
Objective\ud Recent findings have shown that pharmacogenetic manipulations of the Ras-ERK pathway provide a therapeutic means to tackle l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID). First, we investigated whether a prolonged l-DOPA
Autor:
Rick E. Bernardi, Alessandro Papale, Riccardo Brambilla, Andrea Brancale, Livia Marrone, Ilaria Morella, Stefania Fasano, Marzia Indrigo, Francesca Marchisella, Rainer Spanagel
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
Ras-ERK signalling in the brain plays a central role in drug addiction. However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two n
Autor:
Rick E. Bernardi, Stefania Fasano, Alessandro Papale, Rainer Spanagel, Riccardo Brambilla, Marzia Indrigo, Livia Marrone, Ilaria Morella, Andrea Brancale, Francesca Marchisella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382c2e85fa9853533b88cc1ea53643ee
https://doi.org/10.7554/elife.17111.021
https://doi.org/10.7554/elife.17111.021