Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Naoki Fujitsuka"'
Autor:
Chinami, Matsumoto, Hitomi, Sekine, Miwa, Nahata, Sachiko, Mogami, Katsuya, Ohbuchi, Naoki, Fujitsuka, Hiroshi, Takeda
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:780-792
Muscle atrophy is commonly observed during cisplatin chemotherapy, leading to a reduced QOL in cancer patients. Reduced skeletal muscle mass caused by cisplatin treatment results from the activation of ubiquitin ligases-Atrogin-1 and MuRF1, but the p
Autor:
Masaaki Takamura, Naoki Fujitsuka, Masahiro Ogawa, Taiki Nakaya, Masaru Kumagai, Shuji Terai, Shunsuke Nojiri, Suguru Takeuchi, Takeki Sato, Katsuya Ohbuchi, Takayuki Watanabe, Atsunori Tsuchiya, Satoko Motegi, Miwa Nahata, Takahiro Iwasawa
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 18, Iss, Pp 231-241 (2021)
Regenerative Therapy, Vol 18, Iss, Pp 231-241 (2021)
Background Liver cirrhosis is an end-stage multiple liver disease. Mesenchymal stem cells (MSCs) are an attractive cell source for reducing liver damage and regressing fibrosis; additional therapies accompanying MSCs can potentially enhance their the
Autor:
Kunitsugu Kubota, Yumi Harada, Hitomi Sekine, Naoki Fujitsuka, Seiichi Iizuka, Daichi Sadatomi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111860-(2021)
EGFR tyrosine kinase inhibitors (TKIs) are mainly used to treat non-small cell lung cancer; however, adverse effects such as severe diarrhea represent a major obstacle towards the continuation of EGFR-TKIs therapy. Chloride channels, which control th
Autor:
Taro, Oshiro, Yumi, Harada, Kunitsugu, Kubota, Daichi, Sadatomi, Hitomi, Sekine, Mitsue, Nishiyama, Naoki, Fujitsuka
Publikováno v:
Biomedicine & Pharmacotherapy. 152:113263
Changes in the intestinal microbiota are known to occur in constipated patients. Dietary fiber restriction presents obstacles to appropriate defecation and affects fecal properties, but the relationship between fecal microbiota and fecal morphologica
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:466-472
Taste stimulants play important roles in triggering digestion and absorption of nutrients and in toxin detection, under the control of the gut-brain axis. Bitter compounds regulate gut hormone secretion and gastrointestinal motility through bitter ta
Publikováno v:
Scientific Reports
The role of weak acids with pH values in the range of 4–7 has been implicated in the symptoms of gastroesophageal reflux disease (GERD). Prostaglandin E2 (PGE2) is associated with heartburn symptom in GERD patients; however, the precise productive
Autor:
Yumi Harada, Yayoi Saegusa, Seiichi Iizuka, Naoki Fujitsuka, Tomohisa Hattori, Sachiko Mogami
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:78-84
Opioid receptor stimulants are analgesics used in patients with and without cancer; however, they often cause constipation, resulting in poor adherence and deterioration of the quality of life. Hence, suitable treatments for constipation are required
Autor:
Akinobu Taketomi, Masahiro Yamamoto, Mitsuo Shimada, Kunitsugu Kubota, Yuji Morine, Hiroaki Matsushima, Naoki Fujitsuka, Toru Kono, Akihito Mase
Publikováno v:
Neurogastroenterology and Motility
Background The traditional Japanese herbal medicine, daikenchuto (DKT), has been used to treat constipation and postoperative ileus. However, the precise mechanisms involved in the pharmacological effects of DKT remain uncertain. The aim of this stud
Autor:
Shu-Chun Chen, Keong Chong, Wei-Jei Lee, Akihiro Asakawa, Chih Yen Chen, Akio Inui, Shou-Dong Lee, Naoki Fujitsuka
Publikováno v:
Current Medicinal Chemistry. 20:2374-2388
To compare endocrine, metabolic, and inflammatory changes induced by gastric bypass (GB) and sleeve gastrectomy (SG) in patients with type 2 diabetes mellitus (T2DM), and to investigate the mechanisms of success after metabolic surgery. Sixteen GB an
Publikováno v:
Gastroenterology. 154:S-756