Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Michael Lee"'
Autor:
Michael Lee
Publikováno v:
MedEdPORTAL, Vol 11 (2015)
Abstract Introduction This interactive lecture and self-learning module (SLM) on pharmacokinetics was designed to transition students towards independent application of basic pharmacokinetics to clinical cases. The interactive lecture session and the
Externí odkaz:
https://doaj.org/article/39c9a523549645e4b1e8c6c6e121276e
Publikováno v:
Biomolecules & Therapeutics
BRAF inhibitors are insufficient monotherapies for BRAF-mutated cancer; therefore, we investigated which inhibitory pathway would yield the most effective therapeutic approach when targeted in combination with BRAF inhibition. The oncogenic BRAF inhi
Publikováno v:
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras-transformed NIH 3T3 cells (Ras-NIH 3T3
Autor:
Audrey Goddard, Michael Lee, Matthew Peach, Rick Sorensen, Ping Cheng Yi, Marianna Zavodovskaya
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundInhibiting ecto-5’-nucleotidase (CD73) to reduce immunosuppressive adenosine in the tumor microenvironments is an anti-tumor strategy currently explored in clinical trials. Measuring soluble CD73 (sCD73) activity in plasma to evaluate pha
Autor:
Rajagopal Krishnamoorthy, Yusuke Nakamura, Alice Giontella, Elisa Danese, Munir Pirmohamed, Hoi Y. Tong, Angela Tagetti, Marie-Anne Loriot, Pietro Minuz, Anke H. Maitland-van der Zee, Sheng-Lan Tan, Jim K Burmester, Richard B. Kim, Jamila Alessandra Perini, Ming Ta Michael Lee, Nita A. Limdi, Min Huang, Mohamed H. Shahin, Guilherme Suarez-Kurtz, Vanessa Roldán, Carlos Isaza, Hersh Sagreiya, Hye Sun Gwak, Vijay Kumar Kutala, Han-Jing Cen, Russ B. Altman, Antonio J. Carcas, Kunihiko Itoh, Vaiva Lesauskaite, Richard L. Berg, Cristina Mazzaccara, Kyung Eun Lee, Mariana R. Botton, Jieying Eunice Zhang, Anthonius de Boer, Yumao Zhang, Inna Y. Gong, Marianne K. Kringen, Paola Borgiani, Taimour Y. Langaee, Monica Taljaard, Vacis Tatarunas, Panos Deloukas, Chrisly Dillon, Alberto M. Borobia, Michael D. Caldwell, Katarzyna Drozda, Larisa H. Cavallari, Julie A. Johnson, Stephane Bourgeois, Lucia Sacchetti, Saurabh Singh Rathore, Stuart A. Scott, Martina Montagnana, Li-Zi Zhao, Charles A. Rivers, Mahmut Ozer, Taisei Mushiroda, Cristina Lucía Dávila-Fajardo, Andras Paldi, Marisa Cañadas-Garre, Rocío González-Conejero, Talitha I. Verhoef, Sherief Khalifa, Ivet Suriapranata, Carlo Federico Zambon, Balraj Mittal, Sara Raimondi, Ece Genc, Virginie Siguret, Andrea H. Ramirez, Cinzia Ciccacci, Keita Hirai, Enrique Jiménez-Varo, Hong-Hao Zhou, Anil Pathare, Steven A. Lubitz, Josh C. Denny, Aditi Shendre, Leonardo Beltrán, Kari Bente Foss Haug, Cristiano Fava, Vittorio Pengo
Publikováno v:
Clin Pharmacol Ther
Clinical Pharmacology and Therapeutics, 105(6), 1477. Nature Publishing Group
Danese, E, Sara, R, Montagnana, M, Tagetti, A, Langaee, T, Borgiani, P, Ciccacci, C, Carcas, A J, Borobia, A M, Tong, H Y, Davila Fajardo, C, Rodrigues Botton, M, Bourgeois, S, Deloukas, P, Caldwell, M D, Burmester, J K, Berg, R L, Cavallari, L H, Drozda, K, Huang, M, Zhao, L-Z, Cen, H-J, Gonzalez-Conejero, R, Roldan, V, Nakamura, Y, Mushiroda, T, Gong, I Y, Kim, R B, Hirai, K, Itoh, K, Isaza, C, Beltran, L, Jimenez-Varo, E, Cañadas-Garre, M, Giontella, A, Kristiansen Kringen, M, Bente Foss Haug, K, Gwak, H S, Lee, K E, Minuz, P, Lee, M T M, Lubitz, S A, Scott, S, Mazzaccara, C, Sacchetti, L, Genç, E, Özer, M, Pathare, A, Krishnamoorthy, R, Paldi, A, Siguret, V, Loriot, M-A, Kumar Kutala, V, Suarez-Kurtz, G, Perini, J, Denny, J C, Ramirez, A H, Mittal, B, Singh Rathore, S, Sagreiya, H, Altman, R, Shahin, M H A, Khalifa, S I, Lindi, N A, Rivers, C, Shendre, A, Dillon, C, Suriapranata, I M, Zhou, H-H, Tan, S-L, Tatarunas, V, Lesauskaite, V, Zhang, Y, Maitland-van der Zee, A H, Verhoef, T I, de Boer, A, Taljaard, M, Zambon, C F, Pengo, V, zhang, J E, Pirmohamed, M, Johnson, J A & Fava, C 2018, ' The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals ', Clinical Pharmacology and Therapeutics . https://doi.org/10.1002/cpt.1323
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 2019, 105 (6), pp.1477-1491. ⟨10.1002/cpt.1323⟩
Clinical pharmacology and therapeutics, 105(6), 1477-1491. Wiley-Blackwell
Clinical pharmacology and therapeutics
Paediatrics Publications
Clinical Pharmacology and Therapeutics, 105(6), 1477. Nature Publishing Group
Danese, E, Sara, R, Montagnana, M, Tagetti, A, Langaee, T, Borgiani, P, Ciccacci, C, Carcas, A J, Borobia, A M, Tong, H Y, Davila Fajardo, C, Rodrigues Botton, M, Bourgeois, S, Deloukas, P, Caldwell, M D, Burmester, J K, Berg, R L, Cavallari, L H, Drozda, K, Huang, M, Zhao, L-Z, Cen, H-J, Gonzalez-Conejero, R, Roldan, V, Nakamura, Y, Mushiroda, T, Gong, I Y, Kim, R B, Hirai, K, Itoh, K, Isaza, C, Beltran, L, Jimenez-Varo, E, Cañadas-Garre, M, Giontella, A, Kristiansen Kringen, M, Bente Foss Haug, K, Gwak, H S, Lee, K E, Minuz, P, Lee, M T M, Lubitz, S A, Scott, S, Mazzaccara, C, Sacchetti, L, Genç, E, Özer, M, Pathare, A, Krishnamoorthy, R, Paldi, A, Siguret, V, Loriot, M-A, Kumar Kutala, V, Suarez-Kurtz, G, Perini, J, Denny, J C, Ramirez, A H, Mittal, B, Singh Rathore, S, Sagreiya, H, Altman, R, Shahin, M H A, Khalifa, S I, Lindi, N A, Rivers, C, Shendre, A, Dillon, C, Suriapranata, I M, Zhou, H-H, Tan, S-L, Tatarunas, V, Lesauskaite, V, Zhang, Y, Maitland-van der Zee, A H, Verhoef, T I, de Boer, A, Taljaard, M, Zambon, C F, Pengo, V, zhang, J E, Pirmohamed, M, Johnson, J A & Fava, C 2018, ' The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals ', Clinical Pharmacology and Therapeutics . https://doi.org/10.1002/cpt.1323
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 2019, 105 (6), pp.1477-1491. ⟨10.1002/cpt.1323⟩
Clinical pharmacology and therapeutics, 105(6), 1477-1491. Wiley-Blackwell
Clinical pharmacology and therapeutics
Paediatrics Publications
The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association
Publikováno v:
Biomolecules & Therapeutics
Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and -resistant (A375P/Mdr w
Autor:
Harumi Takahashi, Kiyoshi Mihara, Ute I. Schwarz, Saki Shinohara, Ming Ta Michael Lee, Ming-Shien Wen, Rommel G. Tirona, Minami Ohara, Minoli A. Perera, Inna Y. Gong, Richard B. Kim, Larisa H. Cavallari, Edith A. Nutescu, Crystal L. Schmerk, Yasuhiko Suzuki
Publikováno v:
Clinical Pharmacokinetics. 58:1077-1089
Population differences in warfarin dosing requirement have been reported; however, unlike the pharmacokinetics (PK) of warfarin, the quantitative influences of pharmacodynamic (PD) factors on the anticoagulation response to warfarin in different ethn
Autor:
Mariana R. Botton, Michelle Whirl‐Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, José A. G. Agúndez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio‐Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, Andrea Gaedigk
Publikováno v:
Clin Pharmacol Ther
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both, efficacy and safety iss
Autor:
Jae-Gook Shin, Dan M. Roden, Stefan Winter, Paul A. Gurbel, Michiaki Kubo, Braxton D. Mitchell, Joshua P. Lewis, Yuki Bradford, Daniel Aradi, Kevin P. Bliden, Jurriën M. ten Berg, Thomas O. Bergmeijer, Kiyuk Chang, Ruth E. Pakyz, Alan R. Shuldiner, Ho-Sook Kim, Jean-Luc Reny, Meinrad Gawaz, Tobias Geisler, Gianluca Campo, Marco Valgimigli, Elke Schaeffeler, Jolanta M. Siller-Matula, Gian Franco Gensini, Lene Holmvang, Willibald Hochholzer, Rossella Marcucci, Betti Giusti, Ming Ta Michael Lee, Jean-Pierre Déry, Dietmar Trenk, Ming-Shien Wen, John M. Wallace, Marylyn D. Ritchie, Teri E. Klein, Israel Fernandez-Cadenas, Dimitrios Alexopoulos, Matthias Schwab, Ryan Whaley, John H. Cleator, Pierre Fontana, Joshua D. Backman, Russ B. Altman, Shefali S. Verma, Eun Young Kim, Nadia Paarup Dridi, Li Gong, Joan Montaner
Publikováno v:
Clinical Pharmacology & Therapeutics
Clinical Pharmacology and Therapeutics
Verma, S S, Bergmeijer, T O, Gong, L, Reny, J L, Lewis, J P, Mitchell, B D, Alexopoulos, D, Aradi, D, Altman, R B, Bliden, K, Bradford, Y, Campo, G, Chang, K, Cleator, J H, Déry, J P, Dridi, N P, Fernandez-Cadenas, I, Fontana, P, Gawaz, M, Geisler, T, Gensini, G F, Giusti, B, Gurbel, P A, Hochholzer, W, Holmvang, L, Kim, E Y, Kim, H S, Marcucci, R, Montaner, J, Backman, J D, Pakyz, R E, Roden, D M, Schaeffeler, E, Schwab, M, Shin, J G, Siller-Matula, J M, ten Berg, J M, Trenk, D, Valgimigli, M, Wallace, J, Wen, M S, Kubo, M, Lee, M T M, Whaley, R, Winter, S, Klein, T E, Shuldiner, A R, Ritchie, M D & for the ICPC Investigators 2020, ' Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel : A Study by the International Clopidogrel Pharmacogenomics Consortium ', Clinical Pharmacology and Therapeutics, vol. 108, no. 5, pp. 1067-1077 . https://doi.org/10.1002/cpt.1911
Clinical Pharmacology and Therapeutics, Vol. 108, No 5 (2020) pp. 1067-1077
Clinical Pharmacology and Therapeutics
Verma, S S, Bergmeijer, T O, Gong, L, Reny, J L, Lewis, J P, Mitchell, B D, Alexopoulos, D, Aradi, D, Altman, R B, Bliden, K, Bradford, Y, Campo, G, Chang, K, Cleator, J H, Déry, J P, Dridi, N P, Fernandez-Cadenas, I, Fontana, P, Gawaz, M, Geisler, T, Gensini, G F, Giusti, B, Gurbel, P A, Hochholzer, W, Holmvang, L, Kim, E Y, Kim, H S, Marcucci, R, Montaner, J, Backman, J D, Pakyz, R E, Roden, D M, Schaeffeler, E, Schwab, M, Shin, J G, Siller-Matula, J M, ten Berg, J M, Trenk, D, Valgimigli, M, Wallace, J, Wen, M S, Kubo, M, Lee, M T M, Whaley, R, Winter, S, Klein, T E, Shuldiner, A R, Ritchie, M D & for the ICPC Investigators 2020, ' Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel : A Study by the International Clopidogrel Pharmacogenomics Consortium ', Clinical Pharmacology and Therapeutics, vol. 108, no. 5, pp. 1067-1077 . https://doi.org/10.1002/cpt.1911
Clinical Pharmacology and Therapeutics, Vol. 108, No 5 (2020) pp. 1067-1077
Antiplatelet response to clopidogrel shows wide variation, and poor response is correlated with adverse clinical outcomes. CYP2C19 loss-of-function alleles play an important role in this response, but account for only a small proportion of variabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879ba4faf94686e3e39457e594e198cf
http://hdl.handle.net/11392/2437791
http://hdl.handle.net/11392/2437791
Autor:
Byeal-I Han, Michael Lee
Publikováno v:
International Journal of Pharmacology. 12:19-27