Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Maria Diaz"'
Publikováno v:
Biodrugs
New immuno-oncology therapies are improving cancer treatments beyond the former standard of care, as evidenced by the recent and continuing clinical approvals for immunotherapies in a broad range of indications. However, a majority of patients (parti
Autor:
Maria Diaz, Raquel de Benito, Marc Lefebvre, Pedro-Antonio Regidor, Celestino Ronchi, Eric Sicard, Milton Furtado, Jaime Algorta
Publikováno v:
The European Journal of Contraception & Reproductive Health Care. 22:429-438
Objective: To show the clinical development of Ornibel® (ExeltisHealthcare, Spain) a contraceptive vaginal ring manufactured with a new polymer composition and containing etonogestrel/ethin...
Autor:
Francisco J Tinahones, Cristina Maria Diaz-Perdigones, Araceli Muñoz-Garach, Isabel Cornejo-Pareja, María Molina-Vega, Isabel Moreno-Indias
Publikováno v:
Endocrine Abstracts.
Autor:
Matthew C. Coffey, Richard G. Vile, Timothy Kottke, Hardev Pandha, Alan Melcher, Jill Thompson, Kevin J. Harrington, Shane Zaidi, Kevin G. Shim, Christopher Parrish, Liz Ilett, Rosa Maria Diaz, Karishma Rajani
Publikováno v:
Molecular Therapy. 24:166-174
Oncolytic reovirus can be delivered both systemically and intratumorally, in both preclinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and antitumor activity is directly associ
Autor:
Diana Rommelfanger-Konkol, Peter Selby, Timothy Kottke, Elizabeth Ilett, Kevin J. Harrington, Karishma Rajani, Shane Zaidi, Hardev Pandha, Jose S. Pulido, O Donnelly, Alan Melcher, Richard G. Vile, Rosa Maria Diaz, Vanesa Alonso-Camino, Jill Thompson
Publikováno v:
Molecular Therapy. 22(11):1936-1948
Previously, we showed that vesicular stomatitis virus (VSV) engineered to express a cDNA library from human melanoma cells (ASMEL, Altered Self Melanoma Epitope Library) was an effective systemic therapy to treat subcutaneous (s.c.) murine B16 melano
Autor:
Alan Melcher, Oliver Donnelly, Jill Thompson, Hardev Pandha, Candice Willmon, Matthew C. Coffey, Kevin J. Harrington, Shane Zaidi, Rosa Maria Diaz, Peter Selby, Timothy Kottke, Richard G. Vile, Elizabeth Ilett
Publikováno v:
Molecular Therapy. 22(10):1851-1863
Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor
Autor:
Gerard J. Nuovo, Timothy Kottke, Kevin J. Harrington, Alan Melcher, Debabrata Mukhopadhyay, Peter Selby, Jill Thompson, Richard G. Vile, Jose S. Pulido, Matthew C. Coffey, Rosa Maria Diaz, Hardev Pandha, Elizabeth Ilett, John D. Chester
Publikováno v:
Molecular Therapy. 19(10):1802-1812
We have previously reported that a burst of vascular endothelial growth factor (VEGF) signaling to tumor-associated endothelium induces a proviral state, during which systemically delivered oncolytic reovirus can replicate in endothelium, thereby ind
Autor:
Alan Melcher, Feorillo Galivo, Jill Thompson, Kevin J. Harrington, Steven M. Albelda, Rosa Maria Diaz, Timothy Kottke, Phonphimon Wongthida, Candice Willmon, Richard G. Vile
Publikováno v:
Molecular Therapy. 19(1):140-149
Despite having potent oncolytic activity, in vitro, direct intratumoral injection of oncolytic vesicular stomatitis virus (VSV) into established AE17ova mesothelioma tumors in C57Bl/6 mice had no therapeutic effect. During studies to combine systemic
Autor:
Jill Thompson, Rosa Maria Diaz, Phonphimon Wongthida, Timothy Kottke, Alan Melcher, Feorillo Galivo, Richard G. Vile
Publikováno v:
Molecular Therapy. 19:150-158
We show here, for the first time to our knowledge, that the antitumor therapy of oncolytic vesicular stomatitis virus (VSV) in the B16ova model depends upon signaling through myeloid differentiation primary response gene 88 (MyD88) in host cells. VSV
Autor:
M. Cristina Estaii Omana, Irene Ganan Gomez, M. Soledad Vela Gurovic, Maria Del Carmen Boyano Adanez, A. Paula Murray, Pilar Sancho Lopez, A. Maria Diaz Lanza
Publikováno v:
Phytotherapy Research. 25:603-610
Natural occurring compounds are considered an important source of antitumoral agents. In the present study, the cytotoxic potential of three pentacyclic triterpenes isolated from Chuquiraga erinacea (Asteraceae), against the human leukemic cell lines