Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan Hall"'
Publikováno v:
ChemMedChem. 16(22)
Single-stranded phosphorothioate (PS) oligonucleotide drugs have shown potential for the treatment of several rare diseases. However, a barrier to their widespread use is that they exhibit activity in only a narrow range of tissues. One way to circum
Autor:
Jonathan Hall, Daniel Schümperli, Alexandre Theocharides, Anna Elisabeth Minder, Nicole Wildner-Verhey van Wijk, Veronika Lysenko, Jessica Jucker, Elisabeth I. Minder, Xiaoye Schneider-Yin, Jasmin Barman-Aksözen, François Halloy, Alice Ghidini, Chia Pei Grubenmann, Marc-David Ruepp, Pavithra S. Iyer
Publikováno v:
Cell chemical biology. 28(8)
Erythropoietic protoporphyria (EPP) is a rare disease in which patients experience severe light sensitivity. It is caused by a deficiency of ferrochelatase (FECH), the last enzyme in heme biosynthesis (HBS). The lack of FECH causes accumulation of it
Autor:
Jonathan Hall, Ugo Pradere
Publikováno v:
Bioconjugate chemistry. 27(3)
Modified oligonucleotides bearing multiple functional labels are valuable tools in RNA biology. Efficient synthetic access to singly modified short DNAs and RNAs has been developed in the past years and paved the way to a first generation of oligonuc
Publikováno v:
Future medicinal chemistry. 7(13)
Chemical modification and/or the conjugation of small functional molecules to oligonucleotides have significantly improved their biological and biophysical properties, addressing issues such as poor cell penetration, stability to nucleases and low af
Autor:
Jonathan Hall, Pam Ganju
Publikováno v:
Expert Opinion on Biological Therapy. 4:531-542
Chronic pain is a major socio-economic burden which remains poorly treated owing to either the lack of efficacy or the dose-limiting, adverse effects of current clinical therapies. It is currently a subject of intense pharmaceutical activity, focused
Autor:
Gabriele Dorn, Glen Wotherspoon, Jonathan Hall, Stuart Bevan, Sadhana Patel, Samir Abdel'Al, Pam Ganju, Francois Natt, Janet Winter, Alyson Fox, L. H. Eunson, William Leonard Wishart, Sarah Moffatt, Jane Barclay
Publikováno v:
The Journal of Neuroscience. 22:8139-8147
The excitation of nociceptive sensory neurons by ATP released in injured tissue is believed to be mediated partly by P2X(3)receptors. Although an analysis of P2X(3) knock-out mice has revealed some deficits in nociceptive signaling, detailed analysis
Publikováno v:
Bioconjugate Chemistry. 13:945-951
We report here the first successful sequence-specific cleavage of large RNA using artificial ribonucleases. A series of uniformly 2'-methoxyethoxy-modified oligonucleotides bearing a europium complex were investigated as artificial ribonucleases spec
Autor:
Maaly Abd Elrahman, Angela Nauer, Gediminas Mikutis, Dario Neri, Jonathan Hall, Jörg Scheuermann, Raphael M. Franzini, Mauro Zimmermann, Florent Samain
Publikováno v:
BIOCONJUGATE CHEMISTRY
DNA-encoded chemical libraries are collections of small molecules, attached to DNA fragments serving as identification barcodes, which can be screened against multiple protein targets, thus facilitating the drug discovery process. The preparation of
Autor:
Jonathan Hall, Helen L. Lightfoot
Publikováno v:
Nucleic Acids Research, 40 (21)
Nucleic Acids Research
Nucleic Acids Research
Oligonucleotide delivery in vivo is commonly seen as the principal hurdle to the successful development of oligonucleotide drugs. In an analysis of 26 oligonucleotide drugs recently evaluated in late-stage clinical trials we found that to date at lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e049aeb23f954625fcbb8d5588af0a29
https://hdl.handle.net/20.500.11850/63006
https://hdl.handle.net/20.500.11850/63006
Publikováno v:
Chemistry & Biology. 1:185-190
Background: A general method allowing the selective destruction of targeted mRNA molecules in vivo would have broad application in biology and medicine. Metal complexes are among the best synthetic catalysts for the cleavage of RNA, and covalent atta