Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jianjun Zhong"'
Autor:
Jianhua Peng, Zhijian Huang, Cheng Yin, Yue Wu, Jianjun Zhong, Li Jiang, Chongjie Cheng, Xiaochuan Sun, Yong Jiang, Fang Cao, Zongduo Guo
Publikováno v:
CNS Neuroscience & Therapeutics
Introduction Axonal injury results in long‐term neurological deficits in traumatic brain injury (TBI) patients. Apolipoprotein E (ApoE) has been reported to activate intracellular adaptor protein Disabled‐1 (Dab1) phosphorylation via its interact
Autor:
Zhaosi Zhang, Xiaochuan Sun, Zhijian Huang, Chongjie Cheng, Jingchuan Wu, Liu Liu, Hui Li, Junchi He, Li Jiang, Zongduo Guo, Yue Wu, Jianjun Zhong, Hongrong Zhang, Lingjun Qi, Han Liu
Publikováno v:
Neurobiology of Disease, Vol 117, Iss, Pp 114-124 (2018)
Traumatic brain injury (TBI) causes a high rate of mortality and disability worldwide, and there exists almost none effective drugs to protect against TBI. Neurotoxicity occurring after TBI can be derived from microglia and astrocytes, and causes neu
Autor:
Han Liu, Junchi He, Yue Wu, Yang Du, Yinghua Jiang, Chengzhi Chen, Zhanyang Yu, Jianjun Zhong, Zhigang Wang, Chongjie Cheng, Xiaochuan Sun, Zhijian Huang
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience
Background and TargetFollowing brain trauma, blood–brain barrier (BBB) disruption and inflammatory response are critical pathological steps contributing to secondary injury, leading to high mortality and morbidity. Both pathologies are closely asso
Autor:
Jianjun Zhong, Xiaocui Tian, Jingchuan Wu, Xiaochuan Sun, Bo Cen, Tao Jiang, Hui Li, Junchi He, Yuetao Luo, Hongrong Zhang
Publikováno v:
Journal of Neurochemistry
The level of microRNA‐9‐5p (miRNA‐9‐5p) in brain tissues is significantly changed after traumatic brain injury (TBI). However, the effect of miRNA‐9‐5p for brain function in TBI has not been elucidated. In this study, a controlled cortica
Autor:
Jinwei Pang, Minghang Li, Zhi Dong, Jianjun Zhong, Xiaocui Tian, Mei Yang, Jianhua Peng, Jie Lou, Ruidi An, Lu Xu, Qian Zhang
Publikováno v:
Journal of Neurochemistry. 139:757-768
β-caryophyllene (BCP) mediates neuroprotection in cerebral ischemic animals. The neurovascular unit (NVU) acts as an intricate network to maintain the neuronal homeostatic microenvironment. However, the effects exerted by BCP on NVU remain unclear.
Autor:
Xiaochuan Sun, Zongduo Guo, Zhijian Huang, Jianjun Zhong, Li Jiang, Chongjie Cheng, Fang Cao, Zhanyang Yu
Publikováno v:
Journal of Neurochemistry. 136:1017-1025
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in youth, but to date, effective therapies are still lacking. Previous studies revealed a marked response of apolipoprotein J (ApoJ) expression to the brain injury. The aim
Autor:
Jiahua Zhang, Xiaodan Tan, Weiming Du, Junqing Yang, Yuke Li, Congli Hu, Jianjun Zhong, Hong Wang, Haifeng Huang, Zhihao Chen, Hui Xia, Miaomiao Li, Yang Yang, Zhe Peng, Ying Luo
Publikováno v:
Experimental Neurology. 327:113223
Aims Ischemic stroke has become one of the main causes of death worldwide. MicroRNAs (miRNAs) have been implicated in cerebral ischemia-reperfusion (I/R) injury and could serve as therapeutic targets. 5-Lipoxygenase (5-LOX) is a key enzyme in the bio
Autor:
Rami Darwazeh, Li Jiang, Xiaochuan Sun, Han Liu, Jianjun Zhong, Chongjie Cheng, Jingchuan Wu, Junchi He, Yue Wu, Hongrong Zhang, Zhijian Huang
Publikováno v:
Brain, behavior, and immunity. 65
Objective Bexarotene treatments exert neuroprotective effects on mice following traumatic brain injury (TBI). The present study aims to investigate the potential roles of the long noncoding RNA Neat1 in the neuroprotective effects of bexarotene. Mate
Autor:
Jianjun Zhong, Xiaochuan Sun, Junchi He, Li Jiang, Yue Wu, Chongjie Cheng, Hongrong Zhang, Han Liu, Zhijian Huang, Zhipeng Teng, Fang Cao, Jinchuan Wu
Publikováno v:
Neuroscience. 343
Bexarotene has been proved to have neuroprotective effects in many animal models of neurological diseases. However, its neuroprotection in traumatic brain injury (TBI) is still unknown. This study aims to explore the neuroprotective effects of bexaro