Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hongxia Lin"'
Autor:
Yulian Gao, Hongxia Lin, Yumin Xu, Yijin Yao, Dake Shi, Junjie Li, Haixing Zhu, Hanssa Dwarka Summah, Lei Ni, Yun Feng
Publikováno v:
Infection and Drug Resistance. 15:6451-6462
Yulian Gao,1,* Hongxia Lin,1,* Yumin Xu,2,* Yijin Yao,1,* Dake Shi,1 Junjie Li,1 Haixing Zhu,1 Hanssa Dwarka Summah,3 Lei Ni,1 Yun Feng1 1Department of Respiratory and Critical Care Medicine, Ruijin Hospital, School of Medicine, Shang
Autor:
Nancy Chan, Jiuping Ji, Antoinette R. Tan, Janice M. Mehnert, Alice P. Chen, Jan H. Beumer, Mansi Shah, Joseph Aisner, Murugesan Gounder, Jyoti Malhotra, Rebecca A. Moss, Yong Lin, Brian F. Kiesel, Hongxia Lin, Mark N. Stein, Michael P. Kane
Publikováno v:
Cancer Chemother Pharmacol
Purpose Veliparib (V), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, potentiates effects of alkylating agents and topoisomerase inhibitors in preclinical tumor models. We conducted a phase I trial of V with iv cyclophosphamide (C) and V plus
Autor:
Jyoti Malhotra, Eileen White, Daniella E Portal, Joseph Aisner, Hongxia Lin, Mark N. Stein, Rebecca A. Moss, Susan Goodin, Kristen Spencer, Laurence A Doyle, Amanda Kaveney, Darlene Gibbon, Janice M. Mehnert, Joseph R. Bertino, Antoinette R. Tan
Publikováno v:
Cancer Chemotherapy and Pharmacology. 84:899-907
Given the evidence that coordinate inhibition of AKT induces autophagy, we studied the combination of the AKT inhibitor, MK-2206 with hydroxychloroquine (HCQ) in patients with advanced solid tumors. Patients were treated with weekly MK-2206 (135 mg o
Autor:
Hongxia Lin, Rebecca A. Moss, Yujie Zhao, Susan Goodin, Daniella E Portal, Mark N. Stein, Janice M. Mehnert, Antoinette R. Tan, Diana Lindquist, Neal Ready, Joseph Aisner, Darlene Gibbon, Naoko Takebe, Murugeson Gounder
Publikováno v:
Investigational new drugs. 38(3)
Background AT-101 is a BH3 mimetic that inhibits the heterodimerization of Bcl-2, Bcl-xL, Bcl-W, and Mcl-1 with pro-apoptotic proteins, thereby lowering the threshold for apoptosis. This phase I trial investigated the MTD of AT-101 in combination wit
Autor:
Joseph R. Bertino, Hongxia Lin, Murugesan Gounder, Brian Buckley, Oliver S. Eng, Ah-Ng Tony Kong, Darren R. Carpizo, Xin Yu
Publikováno v:
Biomedical Chromatography. 29:1708-1714
ZMC1 {azetidinecarbothioic acid, [1-(2-pyridinyl) ethylidene] hydrazide} is a lead compound being developed as one of the first mutant p53 targeted anti-cancer drugs. Establishing a precise quantitative method is an integral component of this develop
Publikováno v:
Journal of Pharmaceutical Investigation. 42:147-153
Transport studies of model drugs were conducted across the human nasal epithelial (HNE) and normal human bronchial epithelial (NHBE) cell monolayers cultured by air–liquid interface method. Physicochemical properties (e.g., molecular weight, calcul
Autor:
Steven Buyske, Ronald Nahass, Leonid Kagan, Glenn Forrester, Lauren M. Aleksunes, Hongxia Lin, Luigi Brunetti
Purpose Antibiotic dosing in obese surgical patients has not been adequately evaluated. The objective of this study was to identify whether currently prescribed doses of cefoxitin achieve adequate and sustained plasma and tissue concentrations in obe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308035d70311b32774fc6b1d180354ac
https://europepmc.org/articles/PMC4715936/
https://europepmc.org/articles/PMC4715936/
Autor:
Murugesan Gounder, Susan Goodin, Ah-Ng Tony Kong, Robert S. DiPaola, Joseph R. Bertino, M. N. Stein, Hongxia Lin
Publikováno v:
Biomedical Chromatography. 26:650-654
2-Deoxyglucose (2-DG), an analog of glucose, is widely used to interfere with glycolysis in tumor cells and studied as a therapeutic approach in clinical trials. To evaluate the pharmacokinetics of 2-DG, we describe the development and validation of
Autor:
Leonid Kagan, Murugesan Gounder, Tien Yuan Wu, Zheng-Yuan Su, Hu Wang, Ioannis P. Androulakis, Tin Oo Khor, Chengyue Zhang, Hongxia Lin, Sarandeep S.S. Boyanapalli, Ying Huang, Ah-Ng Tony Kong
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 42(4)
3,3′-Diindolylmethane (DIM) has been investigated as a potential anti-cancer chemopreventive agent in many preclinical and clinical studies. In this study, we sought to characterize the pharmacokinetics of DIM and to build a pharmacokinetic (PK) an
Autor:
Hongxia Lin, Joseph R. Bertino, John E. Kerrigan, Kathleen W. Scotto, Philip M. Tedeschi, Murugesan Gounder, Emine Ercikan Abali
Publikováno v:
Molecular pharmacology. 88(4)
NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. The demand for NADPH in cancer cells is elevated as reducing equivalents are required for the high levels of nucleotide,