Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Hongjun Yang"'
Publikováno v:
Acta Materia Medica, Vol 1, Iss 3, Pp 314-319 (2022)
Traditional protein chips are based on solid chips and cannot enable drug and target screening in a label-free manner. Herein, a protein thermal shift chip (PTSC) based on fluorescence signals is proposed, which enables low-cost, high-throughput, lab
Externí odkaz:
https://doaj.org/article/b9a3b7955f5443948b3d69a5396fe65e
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Andrographolide (andro) and its derivatives have been reported to have antitumor activity by arresting the cell cycle. However, the more precise mechanism has been controversial. Here, a proteome chip was used to screen drug targets
Publikováno v:
RSC Medicinal Chemistry.
In order to discover novel anti-pulmonary fibrosis agents, a series of new pirfennidone derivatives were designed and synthesized. All compounds have been investigated for their anti-pulmonary activity and confirmed by 13C and 1H nuclear magnetic res
Publikováno v:
ACS Chemical Neuroscience. 12:2308-2319
Coptidis rhizoma alkaloids (CRAs), extracted from Coptidis rhizoma, have been indicated to play important neuroprotective roles, but the mechanism underlying has not been determined, especially from the perspective of transcription factors (TFs). In
Publikováno v:
Frontiers in Pharmacology. 13
Background: Chronic obstructive pulmonary disease (COPD) is the most common respiratory disease with high morbidity and mortality. Shema oral liquid (Shema) is a traditional Chinese medicine (TCM) approved for the treatment of respiratory diseases. C
Autor:
Gangyi Liu, Hongwei Liu, Wen Tian, Chunxue Liu, Hongjun Yang, Hong Wang, Lumin Gao, Yanna Huang
Publikováno v:
International Immunopharmacology. 117:109888
Publikováno v:
Pharmacological research. 182
Identification of the drug target of lead compounds is an important means for rapid and efficient drug discovery. Protein chips are a high-throughput protein function analysis technology that has been widely used in screening drug protein targets in
Autor:
Yujie Xi, Yan Miao, Rui Zhou, Maolin Wang, Fangbo Zhang, Yu Li, Yi Zhang, Hongjun Yang, Feifei Guo
Publikováno v:
Frontiers in Pharmacology. 13
Retinal degenerative diseases are related to retinal injury because of the activation of the complement cascade, oxidative stress-induced cell death mechanisms, dysfunctional mitochondria, chronic neuroinflammation, and production of the vascular end
Publikováno v:
Frontiers in Pharmacology. 13
C5ar1 (CD88) has been identified as an important potential therapeutic target for regulating inflammation in ischemic stroke. In this study, the neuroprotective effect of Guhong injection (GHI) on middle cerebral artery occlusion (MCAO)-induced reper