Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Helen E. Ritchie"'
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 87
Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine)
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 81
The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. Some human epidemiological studies have associated ondansetron with fetal cardiovascular defects and orofacial clefts. This s
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:144-153
BACKGROUND Dofetilide is an antiarrhythmic drug that blocks the cardiac repolarizing current IKr ((IKr, rapid component of the delayed rectifying potassium current). Previous studies have shown that (a) IKr is essential for normal cardiac function of
Publikováno v:
Reproductive Toxicology. 34:443-450
This study investigated the effects of antipsychotic drugs on heart function of gestational day (GD) 13 rat embryos in vitro since they all block the IKr/hERG potassium ion channel in addition to their main pharmacological effect on neurotransmitters
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0195101 (2018)
PLoS ONE
PLoS ONE
Background Safe use of medications during pregnancy requires a comprehensive understanding of risk-benefit profiles for individual treatments. Pharmacists are supported in this aspect by clinical information agencies (e.g. MotherSafe, a telephone-bas
Publikováno v:
Journal of Ethnopharmacology. 118:127-132
Aim of study Hawthorn (Crataegus) has a long history as a medicine. The current clinical use of hawthorn as a heart medicine dates back to the late 19th century. It is well tolerated clinically yet contraindicated in pregnancy. Materials and methods
Publikováno v:
Journal of pharmacological and toxicological methods. 70(3)
Introduction Although much reproductive toxicology research is performed in live animals there is increasing use of in vitro techniques primarily to identify potential hazards with human exposure. As many in vitro studies are undertaken using protein
Publikováno v:
Current pharmaceutical design. 20(34)
During the organogenic period of development the cardiovascular system of the embryo fulfills several functions including delivery of oxygen and nutrients and a hemodynamic role necessary for cardiac morphogenesis, angiogenesis and hematopoiesis. It
Autor:
Caroline Gavin, Muhammad Khalid Khan, Mats Nilsson, William S. Webster, Deena Ababneh, Kristin Carlsson, Dominique Abela, Helen E. Ritchie
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 89(5)
This study investigated the effects of a range of pharmaceutical drugs with ion channel-blocking activity on the heart of gestation day 13 rat embryos in vitro. The general hypothesis was that the blockade of the I(Kr)/hERG channel, that is highly im
Publikováno v:
Journal of ethnopharmacology. 113(2)
Valerian (Valeriana Officinallis) is a perennial plant used as a mild sedative for anxiety and for insomnia. It is also used in the treatment of gastrointestinal cramps and as a diuretic. It is traditionally contraindicated in pregnancy; however, the