Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Guanghui Zhu"'
Autor:
Baoyi Ni, Xiaotong Song, Bolun Shi, Jia Wang, Qianhui Sun, Xinmiao Wang, Manman Xu, Luchang Cao, Guanghui Zhu, Jie Li
Publikováno v:
Frontiers in pharmacology. 13
Cancer has become one of the major causes of human death. Several anticancer drugs are available; howeve their use and efficacy are limited by the toxic side effects and drug resistance caused by their continuous application. Many natural products ha
Autor:
Ying Tan, Heping Wang, Bowen Xu, Xiaoxiao Zhang, Guanghui Zhu, Yuansha Ge, Taicheng Lu, Ruike Gao, Jie Li
Publikováno v:
Frontiers in Pharmacology. 13
Introduction: The incidence and mortality of gastric cancer ranks among the highest, and the 5-year survival rate of advanced gastric cancer (AGC) is less than 10%. Currently, chemotherapy is the main treatment for AGC, and oxaliplatin is an importan
Autor:
Miaojuan, Fan, Tongtong, Pan, Wei, Jin, Jian, Sun, Shujun, Zhang, Yali, Du, Xinwei, Chen, Qiong, Chen, Wenxin, Xu, Siew Woh, Choo, Guanghui, Zhu, Yongping, Chen, Jie, Zhou
Publikováno v:
Frontiers in Pharmacology. 13
Background: Gestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes, however the underlying mechanisms remain elusive. The aim of this study was to find efficient regulator of FGFs in response to the pathogenesis
Autor:
Kang Wu, Jun Zeng, Xulian Shi, Jiajia Xie, Yuqing Li, Haoxiang Zheng, Guoyu Peng, Guanghui Zhu, Dongdong Tang, Song Wu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Frontiers in Pharmacology
Frontiers in Pharmacology
Bladder cancer is a highly metastatic tumor and one of the most common malignancies originating in the urinary tract. Despite the efficacy of immune checkpoints, including programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4
Autor:
Guanghui Zhu, Xinmiao Wang, Jiayang Chen, Xiaoxiao Zhang, Jia-qi Hu, Jie Li, Ruike Gao, Ming-hao Dai, Bowen Xu, Ying Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Background: Kanglaite injection (KLTI) is a traditional Chinese medicine (TCM) preparation with anti-tumor activity, which has been used to treat malignant tumors in China. The purpose of this study was to evaluate the efficacy and safety of intraple
Autor:
Dezhong Wang, Tianyang Zhao, Yushuo Zhao, Yuan Yin, Yuli Huang, Zizhao Cheng, Beibei Wang, Sidan Liu, Minling Pan, Difei Sun, Zengshou Wang, Guanghui Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN). In the p
Autor:
Dezhong, Wang, Tianyang, Zhao, Yushuo, Zhao, Yuan, Yin, Yuli, Huang, Zizhao, Cheng, Beibei, Wang, Sidan, Liu, Minling, Pan, Difei, Sun, Zengshou, Wang, Guanghui, Zhu
Publikováno v:
Frontiers in Pharmacology
Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN). In the p
Autor:
Mo Li, Yuqi Wei, Ying Zhang, Xiaoqing Zhang, Guanghui Zhu, Shengying Qin, Wei Zhou, Hao Wu, Lin He, Na Zhang, Luan Chen, Zhiruo Zhang, Lu Shen, Cong Huai, Xiaoyan Qiu
Publikováno v:
Clinical Pharmacology & Therapeutics. 106:1389-1397
Tuberculosis (TB) is one of the most prevalent infections. However, anti-TB drugs induce adverse liver injury in up to 40% of patients. Studies on candidate genes have suggested that single-nucleotide polymorphisms account for only a small contributi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 124, Iss, Pp 109740-(2020)
On account of the acquired drug resistance, the potency of cisplatin-based chemotherapy is far from satisfactory in rectal cancer. Increasing evidence has highlighted the crucial function of aberrantly expressed lncRNAs on the cisplatin resistance in
Autor:
Tianyang Zhao, Zhengle He, Xiaokun Li, Yushuo Zhao, Hui Jin, Zhou Jie, Chao Zheng, Yang Wang, Lei Ying, Meng-Yun Jin, Lingwei Jin, Miaojuan Fan, Xinyu Zhao, Wei Jin, Guanghui Zhu, Wei Lin, Zhifeng Huang, Dezhong Wang
Publikováno v:
Cell Death and Disease, Vol 10, Iss 6, Pp 1-14 (2019)
Currently, there is a lack of effective therapeutic approaches to the treatment of chronic kidney disease (CKD) with irreversible deterioration of renal function. This study aimed to investigate the ability of mutant FGF1 (FGF1ΔHBS, which has reduce