Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Davide Trotti"'
Autor:
Andrew T. Nelson, Davide Trotti
Publikováno v:
Neurotherapeutics
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily affects motor neurons and causes muscle atrophy, paralysis, and death. While a great deal of progress has been made in deciphering the underlying pathogenic
Autor:
Silvia Bonanno, Loqman A. Mohamed, Piera Pasinelli, Davide Trotti, Shashirekha S. Markandaiah
Publikováno v:
The AAPS Journal. 19:1600-1614
The blood–brain barrier (BBB) is essential for proper neuronal function, homeostasis, and protection of the central nervous system (CNS) microenvironment from blood-borne pathogens and neurotoxins. The BBB is also an impediment for CNS penetration
Autor:
Angelo C. Lepore, Davide Trotti, Victoria J. Gennaro, Michael R. Jablonski, Piera Pasinelli, Ke Li, Ni J. Meng, Shashirekha S. Markandaiah, Dena Jacob
Publikováno v:
Annals of Clinical and Translational Neurology
The limited progress in identifying successful therapies in Amyotrophic Lateral Sclerosis (ALS) has only resulted in one moderately effective pharmacological agent, riluzole.1,2 In research on the SOD1-G93A mouse model of ALS, riluzole showed a modes
Autor:
Nicholas J. Maragakis, Davide Trotti, Michael R. Jablonski, Christopher R. Campos, Dena Jacob, Piera Pasinelli, David S. Miller
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 2, Pp 194-200 (2012)
ATP-binding cassette (ABC) drug efflux transporters in the CNS are predominantly localized to the luminal surface of endothelial cells in capillaries to impede CNS accumulation of xenobiotics. Inflammatory mediators and cellular stressors regulate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357368c3e743041d1c152bd9b7674f27
https://europepmc.org/articles/PMC3367047/
https://europepmc.org/articles/PMC3367047/
Autor:
Piera Pasinelli, William Boston-Howes, Davide Trotti, Alexey Bogush, Maura Scolere, Eric O. Williams
Publikováno v:
Experimental neurology. 213(1)
Synaptic accumulation of glutamate causes neuronal death in many neurodegenerative pathologies including amyotrophic lateral sclerosis. Drugs capable of increasing glutamate uptake could therefore be therapeutically effective. We screened in a cell-b
Publikováno v:
European journal of pharmacology. 370(2)
Idebenone, a compound with protective efficacy against neurotoxicity both in in vitro and in in vivo models, exists in two different oxidative states: the ubiquinol-derivative (reduced idebenone) and the ubiquinone-derivative (oxidised idebenone). In
Publikováno v:
Trends in pharmacological sciences. 19(8)
A number of neurological cases characterized by sensory disturbances and ataxia were described in the 1950s in Minamata, Japan. Such syndromes were attributed to the ingestion of fish contaminated with methylmercury (MeHg)[71xHarada, M. Crit. Rev. To
Publikováno v:
Scopus-Elsevier
Publikováno v:
European Neuropsychopharmacology. 3:182-183
Our data show that arachidonic acid and oxygen free radicals converge in potently inhibiting high-affinity glutamate uptake with two distinct molecular mechanisms. Since the levels of free fatty acids and reactive oxygen species dramatically increase