Zobrazeno 1 - 2
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pro vyhledávání: '"Caitlin Schafer"'
Autor:
Caitlin Schafer, Vicky Moore, Nupur Dasgupta, Sabzali Javadov, Jeanne F. James, Alexander I. Glukhov, Arnold W. Strauss, Zaza Khuchua
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology
Frontiers in Pharmacology
Aim: Tafazzin knockdown (TazKD) in mice is widely used to create an experimental model of Barth syndrome (BTHS) that exhibits dilated cardiomyopathy and impaired exercise capacity. Peroxisome proliferator-activated receptors (PPARs) are a group of nu
Autor:
Mindong Ren, John L. Jefferies, Yan Huang, Frédéric M. Vaz, Alexander V. Glukhov, Victoria Moore, Colin K.L. Phoon, Corey Powers, Sabzali Javadov, Arnold W. Strauss, Jeanne James, Zaza Khuchua, Caitlin Schafer
Publikováno v:
Orphanet Journal of Rare Diseases
Orphanet journal of rare diseases, 12(1). BioMed Central
Orphanet journal of rare diseases, 12(1). BioMed Central
Background The PGC-1α/PPAR axis has been proposed as a potential therapeutic target for several metabolic disorders. The aim was to evaluate the efficacy of the pan-PPAR agonist, bezafibrate, in tafazzin knockdown mice (TazKD), a mouse model of Bart