Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Arvind K. Srivastava"'
Autor:
Venkateswarlu Korthikunta, Rohit Singh, Rohit Srivastava, Jyotsana Pandey, Atul Srivastava, Upma Chaturvedi, Akansha Mishra, Arvind K. Srivastava, Akhilesh K. Tamrakar, Narender Tadigoppula
Publikováno v:
RSC Medicinal Chemistry. 14:470-481
Novel dual acting benzofuran-based chromenochalcones were synthesized and assessed for in vitro and in vivo antihyperglycemic and antidyslipidemic activities.
In vitro, In vivo and In silico Antihyperglycemic Activity of Some Semi-Synthetic Phytol Derivatives
Autor:
Santosh K. Srivastava, Jyotsana Pandey, Arvind K. Srivastava, Harish C. Upadhyay, Feroz Khan, Pooja Sharma, Akhilesh K. Tamrakar, Akansha Mishra
Publikováno v:
Medicinal Chemistry. 18:115-121
Background: Due to the prevalence of type-2 diabetes across the globe, there is unmet need to explore new molecular targets for the development of cost-effective and safer antihyperglycemic agents. Objective: Structural modification of phytol and eva
Autor:
Neha Rahuja, Harish Kumar, Hari Narayan Kushwaha, Bhawani Singh, A. K. Misra, Jyoti Gupta, Arvind K. Srivastava, Natasha Jaiswal, Ram Pratap, Anil Kumar Dwivedi, Dharmendra P Singh, Ishbal Ahmad, P. C. Verma, Rohit Srivastava, Anand P. Gupta, Akhilesh K. Tamrakar, Sabyasachi Sanyal, Sheo K. Singh, Varsha Gupta, Jiaur R. Gayen
Publikováno v:
Pharmacology. 107:54-68
Introduction: The present study deals with the synthesis of pregnane-oximino-amino-alkyl-ethers and their evaluation for antidiabetic and anti-dyslipidemic activities in validated animal and cell culture models. Methods: The effect on glucose toleran
Autor:
Kanika Varshney, Arvind K. Srivastava, Sudha Jain, Akansha Mishra, Amit K Gupta, Mridula Saxena, Rohit Srivastava, Anil Kumar Saxena, Arun Rawat
Publikováno v:
Chemical Biology & Drug Design. 94:1378-1389
In our continued effort to discover novel PTP1B inhibitor with improved in vivo activity, we attempted to optimize our previously discovered lead compound by replacing the sulfonyl group with benzoyl group to yield compound II. Additional structural
Autor:
Shachi Mishra, Anand P. Gupta, Jyotsana Pandey, Neha Rahuja, Gaurav Taneja, Arun Rawat, Chandra Prakash Gupta, Natasha Jaiswal, Rohit Srivastava, Arvind K. Srivastava, Jiaur R. Gayen, Atul Goel, Akhilesh K. Tamrakar
Publikováno v:
MedChemComm. 8:329-337
Based on high throughput screening of our chemical library, we identified two 4,5-dihydro-2H-benzo[e]indazole derivatives (5d and 5g), which displayed a significant effect on glucose uptake in L6 skeletal muscle cells. Based on these lead molecules,
Glucose uptake stimulatory potential and antidiabetic activity of the Arnebin-1 from Arnabia nobelis
Autor:
Akhilesh K. Tamrakar, Sabbu Sathish Reddy, Arvind K. Srivastava, Tadigoppula Narender, Akansha Mishra, Sukanya Pandeti, Deepti Arha
Publikováno v:
European Journal of Pharmacology. 789:449-457
The enhanced disposal of glucose by the peripheral tissue is an important mechanism to regulate hyperglycemia. Here, we investigated the effect of Arnebin-1 from Arnebia nobilis, on glucose disposal in skeletal muscle cells and explored its in vivo a
Autor:
Amit K. Gupta, Salil Varshney, Kanika Varshney, Ravi Sonkar, Sudha Jain, Arvind K. Srivastava, Anil Kumar Saxena, Akanksha Mishra, Mridula Saxena, Anil N. Gaikwad, Geetika Bhatia
A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Of the 12 tested, 3 compounds (6c, 7b and 7d) showed good anti-oxidant activity, compound 6c attenuated LDL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b185bff533b25739b33a1767f0b401e
Autor:
Arvind K. Srivastava, Mohsin Ali Khan, Aditi Srivastava, Sunaina Chaubey, Tanvir R Jafri, Tahmeena Khan, Anamika Gupta, Zainab Siddiqui, Rumana Ahmad, Anvesha Srivastava
Publikováno v:
Anti-cancer agents in medicinal chemistry. 20(2)
Nature is a rich source of natural drug-like compounds with minimal side effects. Phytochemicals better known as “Natural Products” are found abundantly in a number of plants. Since time immemorial, spices have been widely used in Indian cuisine
Autor:
Rohit Srivastava, Narender Tadigoppula, Arvind K. Srivastava, Jyotsana Pandey, Akhilesh K. Tamrakar, Venkateswarlu Korthikunta, Rohit Singh
Publikováno v:
Phytomedicine. 22:66-70
The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3–11 and 13–18) were prepared from the naturally occurring 4-hydroxyisoleucine (1)
Autor:
Venkateswarlu Korthikunta, Arun Rawat, Akhilesh K. Tamrakar, Sudeep Gautam, Savita Pal, Arvind K. Srivastava, Narender Tadigoppula
Publikováno v:
Fitoterapia. 99:307-317
4-Hydroxyisoleucine (4-HIL) is an unusual amino acid isolated from fenugreek seeds (Trigonella foenum graecum L). Various studies have shown that it acts as an antidiabetic agent yet its mechanism of action is not clear. We therefore investigated the