Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Amy W. Lasek"'
Autor:
Milagros Galán-Llario, María Rodríguez-Zapata, Teresa Fontán-Baselga, Esther Gramage, Marta Vicente-Rodríguez, José María Zapico, Beatriz de Pascual-Teresa, Amy W. Lasek, Gonzalo Herradón
En: Neuropharmacology ISSN. 0028-3908 n. 227 (2023) Pleiotrophin (PTN) is a cytokine that modulates ethanol drinking and reward and regulates glial responses in different contexts. PTN is an inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6215d53e6dee0abc2649d756da085b6
http://hdl.handle.net/10637/14115
http://hdl.handle.net/10637/14115
Autor:
Amy W. Lasek, Donghong He
Publikováno v:
Mol Pharmacol
The dopamine D2 receptor (D2R) is a G protein-coupled receptor (GPCR) expressed in regions of the brain that control motor function, cognition, and motivation. As a result, D2R is involved in the pathophysiology of disorders such as schizophrenia and
Autor:
Amy W. Lasek, Kana Hamada
Publikováno v:
Neurotherapeutics
The receptor tyrosine kinases (RTKs) are a large family of proteins that transduce extracellular signals to the inside of the cell to ultimately affect important cellular functions such as cell proliferation, survival, apoptosis, differentiation, and
Autor:
Subhash C. Pandey, Bertha J. Vandegrift, Donghong He, Chang You, Mark S. Brodie, Antonia Savarese, Amy W. Lasek
Publikováno v:
Neuropharmacology. 144:29-36
Alcohol excitation of the ventral tegmental area (VTA) is important in neurobiological processes related to the development of alcoholism. The ionotropic receptors on VTA neurons that mediate ethanol-induced excitation have not been identified. Quini
Autor:
Amy W. Lasek, Chang You, Mark S. Brodie, Subhash C. Pandey, Huaibo Zhang, Bertha J. Vandegrift
Publikováno v:
Alcoholism, Clinical and Experimental Research
Background The ventral tegmental area (VTA) is important for alcohol-related reward and reinforcement. Mouse VTA neurons are hyposensitive to γ-aminobutyric acid (GABA) during ethanol (EtOH) withdrawal, and GABA responsiveness is normalized by in vi
Autor:
Ying Chen, Amy W. Lasek, Hu Chen, Wei-Yang Chen, Dennis R. Grayson, Kana Hamada, Huaibo Zhang, Jenny Drnevich, Eleonora Gatta, Harish R. Krishnan, Subhash C. Pandey, Mark Maienschein-Cline
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain molecular mechanisms that drive withdrawal-related depression is important for finding new drug targ
Autor:
Carmen Pérez-García, Miryam Pastor, Antonio Pineda-Lucena, Bruno Di Geronimo, Esther Gramage, Leonor Puchades-Carrasco, Claire Coderch, Marta Vicente-Rodríguez, Ana Ramos, Beatriz de Pascual-Teresa, Rosalía Fernández-Calle, Amy W. Lasek, José María Zapico, Gonzalo Herradón
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Ty
Autor:
Amy W. Lasek, Hu Chen
Publikováno v:
Addict Biol
One of the most pernicious characteristics of alcohol use disorder is the compulsion to drink despite negative consequences. The insular cortex controls decision making under conditions of risk or conflict. Cortical activity is tightly controlled by
Autor:
Elizabeth J. Glover, Subhash C. Pandey, Eleonora Gatta, Huaibo Zhang, Amy W. Lasek, Wei-Yang Chen
Publikováno v:
Alcohol
Withdrawal from chronic alcohol drinking can cause depression, leading to an inability to function in daily life and an increased risk for relapse to harmful drinking. Understanding the causes of alcohol withdrawal-related depression may lead to new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea7008b9d90c5398f8fee224e01036c
https://europepmc.org/articles/PMC6612300/
https://europepmc.org/articles/PMC6612300/
Publikováno v:
Addiction Biology. 22:665-678
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase associated with alcohol dependence in humans and behavioral responses to ethanol in mice. To characterize the ability of ALK to control ethanol consumption, we treated mice with the ALK i