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Autor:
Dietmar W. Siemann, Michael R. Horsman
Publikováno v:
Siemann, D W & Horsman, M R 2015, ' Modulation of the tumor vasculature and oxygenation to improve therapy ', Pharmacology & Therapeutics, vol. 153, no. 9, pp. 107-24 . https://doi.org/10.1016/j.pharmthera.2015.06.006
The tumor microenvironment is increasingly recognized as a major factor influencing the success of therapeutic treatments and has become a key focus for cancer research. The progressive growth of a tumor results in an inability of normal tissue blood
Autor:
Carlos Rinaldi, Dietmar W. Siemann, Ana C. Bohórquez, Mythreyi Unni, Lori Rice, Sayali Belsare, Andreina Chiu-Lam, Christine Pampo
Publikováno v:
Bioconjugate chemistry. 29(8)
Low tumor accumulation following systemic delivery remains a key challenge for advancing many cancer nanomedicines. One obstacle in engineering nanoparticles for high tumor accumulation is a lack of techniques to monitor their stability and mobility
Publikováno v:
Siemann, D W, Chaplin, D J & Horsman, M R 2017, ' Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer ', Cancer Investigation, vol. 35, no. 8, pp. 519-534 . https://doi.org/10.1080/07357907.2017.1364745
Vascular targeted therapies (VTTs) are agents that target tumor vasculature and can be classified into two categories: those that inhibit angiogenesis and those that directly interfere with established tumor vasculature. Although both the anti-angiog
Autor:
Helmut Rosemeyer, Barbara Kaltschmidt, Malayko Montilla Martinez, Christian Kaltschmidt, Roland Brandt, Jürgen J. Heinisch, Lidia Bakota, Janine Müller, Maria Siemann, Katharina Raasch, Edith Malecki
Publikováno v:
Chemical Biology & Drug Design. 86:129-143
Nucleoside analogs (NSAs) were among the first chemotherapeutic agents and could also be useful for the manipulation of cell fate. To investigate the potential of NSAs for the induction of neuronal differentiation, we developed a novel phenotypic ass
Autor:
James P. Farese, Dietmar W. Siemann, Marc E. Salute, Valery F. Scharf, Rowan J. Milner, Matti Kiupel, Jeffrey R. Abbott
Publikováno v:
Anti-Cancer Drugs. 25:332-339
Osteosarcoma is a highly fatal cancer, with most patients ultimately succumbing to metastatic disease. The purpose of this study was to evaluate the effects of the antirheumatoid drug aurothiomalate on canine and human osteosarcoma cells and on canin
Autor:
Nikolett Molnar, Dietmar W. Siemann
Publikováno v:
Journal of Cancer Therapy. :1-6
Angiogenesis, the growth of new vessels from pre-existing ones, is an important feature of tumor growth that has been exploited as a therapeutic target in oncology. Given its key role in facilitating blood vessel sprouting, VEGF has been a major focu
Autor:
Dietmar W. Siemann
Publikováno v:
Cancer Treatment Reviews. 37:63-74
The vasculature of solid tumors is fundamentally different from that of normal vasculature and offers a unique target for anti-cancer therapy. Direct vascular-targeting with Tumor-Vascular Disrupting Agents (Tumor-VDAs) is distinctly different from a
Autor:
Schifano, Fabrizio, Albanese, Antonio, Fergus, Suzanne, Stair, Jackie L., Deluca, Paolo, Corazza, Ornella, Davey, Zoe, Corkery, John, Siemann, Holger, Scherbaum, Norbert, Farre', Magi', Torrens, Marta, Demetrovics, Zsolt, Ghodse, A. Hamid, Di Furia, Lucia, Flesland, Liv, Mannonen, Miia, Majava, Aino, Pagani, Stefania, Peltoniemi, Teuvo, Pasinetti, Manuela, Pezzolesi, Cinzia, Skutle, Arvid, Van Der Kreeft, Peer, Enea, Aurora, Di Melchiorre, Giuditta, Shapiro, Harry, Sferrazza, Elias, Drummond, Colin, Pisarska, Agnieszka, Mervo, Barbara, Moskalewicz, Jacek, Haugen, Lill Susann Ynnesdal
Publikováno v:
Psychopharmacology. 214:593-602
Recently, those substances deriving from the active ingredient of the Khat plant, cathinone, have been rising in popularity. Indeed, 4-methylmethcathinone (mephedrone; 'meow meow' and others) has been seen by some as a cheaper alternative to other cl
Autor:
Dietmar W. Siemann, David J. Chaplin
Publikováno v:
Expert Opinion on Drug Discovery. 2:1357-1367
Traditional methods of improving cancer therapy have focused primarily on achieving increased tumor cell kill. However, more recent strategies involve impairing the nutritional support system of the tumor by targeting the tumor vasculature. Rapid dev