Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Reinaldo N. Takahashi"'
Publikováno v:
European Neuropsychopharmacology. 24:1091-1102
The endocannabinoid (eCB) and glucocorticoid systems contribute to the modulation of emotional states. Noteworthy, glucocorticoid hormones are released by adrenal glands during stressful events and endocannabinoids are released in the brain during fe
Autor:
Carla I. Tasca, Carina Akemi Nakamura, Tetsadê C. B. Piermartiri, Reinaldo N. Takahashi, Fabrício Luiz Assini
Publikováno v:
Behavioural Pharmacology. 23:292-301
The aim of this study was to characterize the interaction of adenosine A1-receptor and cannabinoid CB1-receptor antagonists in the water maze and object-location tasks, and to evaluate the participation of glutamatergic neurotransmission in the hippo
Publikováno v:
Psychopharmacology. 188:641-649
Rationale Previous studies demonstrated that pharmacological blockade of CB1 cannabinoid receptors decreases the extinction of conditioned fear and spatial memory in rodents. However, the effects of CB1 cannabinoid receptor activation in this respons
Publikováno v:
Neuroscience Letters. 349:49-52
The effect of systemic administration of the cannabinoid antagonist SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxyamide) on penile erection and yawning induced by apomorphine was investigated in rats. SR 141716A (2 m
Publikováno v:
Pharmacology Biochemistry and Behavior. 75:763-768
Cannabinoid receptor agonists significantly inhibit nociceptive responses in a large number of animal models. The present study examined whether mice displaying different basal levels of anxiety in the plus-maze test of anxiety might differ in terms
Publikováno v:
Neuroscience letters. 470(1)
Evidence are that inhibition of cyclooxygenase 2 (COX-2) enhances endocannabinoid signaling, indicating a crosstalk between these two eicosanoid pathways. Aspirin, a non-selective COX inhibitor, acetylates COX-2 with generation of a lipoxygenase (LOX
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 18(12)
The present study investigated the central effects of the eCB uptake/metabolism inhibitor AM404 and the phytocannabinoid cannabidiol (CBD) on the extinction of contextual fear memories in rats. Rats were conditioned and 24 h later subjected to three
Publikováno v:
Psychopharmacology. 194(2)
Our previous findings have shown rapid cross-tolerance between ethanol and Delta(9)-tetrahydrocannabinol and that intraperitoneal (i.p.) injection of cannabinoid receptor type 1 (CB1R) antagonist SR141716 (SR) does not interfere with tolerance to eit
Publikováno v:
European journal of pharmacology. 563(1-3)
Converging evidence points to adolescence as a critical period for the onset of a wide range of neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and drug abuse. Spontaneously hypertensive rats (SHR) are generally
Publikováno v:
European journal of pharmacology. 431(2)
Motor incoordination in the rota-rod test was used to assess the development of rapid tolerance to Delta(9)-tetrahydrocannabinol and rapid cross-tolerance between ethanol and Delta(9)-tetrahydrocannabinol in mice. Further, the influence of the cannab