Zobrazeno 1 - 10
of 37
pro vyhledávání: '"L. James Lee"'
Autor:
Jing Zhu, Lesheng Teng, Jing Xie, Aili Zhang, Feng Chen, Chen Kang, Xinmei Wang, Tairong Kuang, Zhaogang Yang, Xiaobing Wang, Robert J. Lee, L. James Lee, Chi-Ling Chiang, Bo Yu, Zhou Chen
Publikováno v:
Journal of Controlled Release. 243:160-171
Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subje
Autor:
Veysi Malkoc, Fay Catacutan, Andrew F. Adler, Hamza N. Gokozan, Traci A. Wilgus, Xinmei Wang, Wei Ching Liao, Cristina Ortiz, Jose Otero, Patrick Gygli, Candice C. Askwith, Chandan K. Sen, Savita Khanna, Cameron Rink, Subhadip Ghatak, Catherine Czeisler, Daniel Gallego-Perez, L. James Lee, Brian C. Wulff, Junyu Ma, Surya Gnyawali, Xi Zhao, Aaron Cowgill, Kam W. Leong, Thomas W. Sherwood
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 12:399-409
Safety concerns and/or the stochastic nature of current transduction approaches have hampered nuclear reprogramming's clinical translation. We report a novel non-viral nanotechnology-based platform permitting deterministic large-scale transfection wi
Autor:
Parker S. Woods, Serge P. Nana-Sinkam, Chang Liu, Nicholas M. Chesarino, Junyu Ma, Yun Wu, Ian C. Davis, L. James Lee
Publikováno v:
Journal of Controlled Release. 203:140-149
Alveolar type II (ATII) respiratory epithelial cells are essential to normal lung function. They may be also central to the pathogenesis of diseases such as acute lung injury, pulmonary fibrosis, and pulmonary adenocarcinoma. Hence, ATII cells are im
Autor:
Daniel Gallego-Perez, Xinmei Wang, Ichiro Nakano, L. James Lee, Zhaogang Yang, Jing Xie, Xiaomeng Huang, Junyu Ma, Xi Zhao
Publikováno v:
Current Pharmaceutical Biotechnology. 15:839-846
Objective: Among heterogeneous glioblastoma multiforme (GBM) cells, glioblastoma stem cells (GSCs) is a subpopulation having a critical role in tumor initiation and therapy resistance. Thus targeting GSCs would be an essential step to completely erad
Autor:
Ching-Shih Chen, Yicheng Mao, Ribai Yan, Natarajan Muthusamy, Hao Li, John C. Byrd, Jiang Wang, Yuan Zhao, Mitch A. Phelps, Robert J. Lee, L. James Lee
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 98:160-165
OSU-2S is a novel anti-cancer and immune modulatory agent designed specifically to avert the immunosuppressive effects and related toxicities observed in clinical studies with its predecessor analog, FTY720. To characterize its preclinical pharmacoki
Autor:
Hongyan He, Xinmei Wang, Bo Yu, Chenguang Zhou, Xiaokui Mo, Robert J. Lee, L. James Lee, Huliang Jia, Samson T. Jacob, Lu Wang, Wei Ren, Kalpana Ghoshal
Publikováno v:
Journal of Controlled Release. 172:690-698
Many cationic lipids have been developed for lipid-based nanoparticles (LNPs) for delivery of siRNA and microRNA (miRNA). However, less attention has been paid to “helper lipids”. Here, we investigated several “helper lipids” and examined the
Autor:
Shu-Hao Hsu, Kalpana Ghoshal, Yuanzhi Lu, Bo Yu, Xinmei Wang, Carl Schmidt, Robert J. Lee, L. James Lee, Samson T. Jacob
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 9:1169-1180
miR-122, a liver-specific tumor suppressor microRNA, is frequently down-regulated in hepatocellular carcinoma (HCC). LNP-DP1, a cationic lipid nanoparticle formulation, was developed as a vehicle to restore deregulated gene expression in HCC cells by
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 9:504-513
Mechanistic understanding of intracellular trafficking is important for the development of small interfering RNA (siRNA) delivery vehicles. Here, we describe a novel methodology to quantitatively analyze nanocarrier-mediated disposition of siRNA. Cel
Autor:
Bo Yu, Valerie P. Grignol, Hongyan He, Alessandra C. Schmitt, William E. Carson, Eric Luedke, Xulang Zhang, Ben McClarren, L. James Lee
Publikováno v:
Journal of Controlled Release. 165:226-233
Herein we describe the development and implementation of a nanoporous cell-therapy device with controllable biodegradation. Dopamine-secreting PC12 cells were housed within newly formulated alginate-glutamine degradable polylysine (A-GD-PLL) microcap
Autor:
Mohammad Alinoor Rahman, Clayton Deighan, Kwang J. Kwak, Elga Bandeira, L. James Lee, Scott Baldwin, Michael E. Paulaitis, Patrick Nana-Sinkam
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 13(2)
We present a method that takes advantage of the fluorophore loading dependence of fluorescence nanoparticle tracking (fNTA) to determine the content of specific miRNA targets in extracellular vesicles (EVs) and their stoichiometry across the entire E