Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert A. Lazarus"'
Publikováno v:
European Journal of Biochemistry. 202:1073-1082
The purification and characterization of six isoforms of ornatin, potent glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and platelet aggregation inhibitors are described. These isoforms were purified from whole leech homogenates of the leech Placobd
Autor:
Theresa A. Deisher, Robert A. Lazarus, Michael T. Lipari, Mark S. Dennis, Mary A. Napier, William J. Henzel, Robert M. Pitti, Stuart Bunting
Publikováno v:
Proceedings of the National Academy of Sciences. 87:2471-2475
The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins that are platelet glycoprotein (GP) IIb-IIIa antagonists and potent inhibitors of platelet aggregation. The primary stru
Publikováno v:
Protein science : a publication of the Protein Society. 9(8)
Decorsin is an antagonist of integrin alphaIIbbeta3 and a potent platelet aggregation inhibitor. A synthetic gene encoding decorsin, originally isolated from the leech Macrobdella decora, was designed, constructed, and expressed in Escherichia coli.
Autor:
Charles Eigenbrot, Mark Ultsch, Lydia Santell, Mary Dwyer, Robert A. Lazarus, Mark S. Dennis, Nicholas J. Skelton, Mark P. O'Connell
Publikováno v:
Nature. 404(6777)
Potent anticoagulants have been derived by targeting the tissue factor-factor VIIa complex with naive peptide libraries displayed on M13 phage. The peptides specifically block the activation of factor X with a median inhibitory concentration of 1 nM
Publikováno v:
Science (New York, N.Y.). 264(5167)
The structure of the leech protein decorsin, a potent 39-residue antagonist of glycoprotein IIb-IIIa and inhibitor of platelet aggregation, was determined by nuclear magnetic resonance. In contrast to other disintegrins, the Arg-Gly-Asp (RGD)-contain
Autor:
Michael Shuster, Robert S. McDowell, Andrea Louie, Mark S. Dennis, Robert A. Lazarus, Michael G. Mulkerrin
Publikováno v:
Biochemistry. 31(20)
The purification, complete amino acid sequence, functional activity, and structural modeling are described for mambin, a platelet glycoprotein GP IIb-IIIa antagonist and potent inhibitor of platelet aggregation from the venom of the Elapidae snake De
Publikováno v:
Science (New York, N.Y.). 253(5018)
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spect
Autor:
David A. Estell, Jana L. Seymour, Jeffrey V. Miller, Kevin Stafford, Stephen Anderson, William Harry Rastetter, Robert A. Lazarus, David R. Light, Cara B. Marks
Publikováno v:
Science. 230:144-149
A new metabolic pathway has been created in the microorganism Erwinia herbicola that gives it the ability to produce 2-keto-L-gulonic acid, an important intermediate in the synthesis of L-ascorbic acid. Initially, a Corynebacterium enzyme that could