Zobrazeno 1 - 10
of 25
pro vyhledávání: '"A. Al-Obeidi"'
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 1278, p 1278 (2021)
Volume 13
Issue 8
Pharmaceutics, Vol 13, Iss 1278, p 1278 (2021)
Volume 13
Issue 8
The peptide hormone Angiotensin (1—7), Ang (1—7) or (Asp-Arg-Val-Tyr-Ile-His-Pro), is an essential component of the renin–angiotensin system (RAS) peripherally and is an agonist of the Mas receptor centrally. Activation of this receptor in the
Autor:
John R. Yates, Magda Stankova, Aaron Aslanian, Li Ma, Jacques Mauger, Stephen Rush Fuhs, Alan Binnie, Tony Hunter, Fahad Al-Obeidi, Anna Zagórska, Greg Lemke, Jill Meisenhelder
Publikováno v:
Cell. 162(1):198-210
SummaryHistidine phosphorylation (pHis) is well studied in bacteria; however, its role in mammalian signaling remains largely unexplored due to the lack of pHis-specific antibodies and the lability of the phosphoramidate (P-N) bond. Both imidazole ni
Publikováno v:
International Journal of Peptide and Protein Research. 35:228-234
Based on structure-activity relationships of the potent alpha-MSH agonist, Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10-NH2, several analogs of the general formula Ac-Nle4-Asp5-Waa6-Xaa7-Yaa8-Zaa9-Lys10+ ++-NH2 were synthesized and tested on frog and liz
Autor:
James A. Ostrem, Michal Lebl, Peter Strop, Fahad Al-Obeidi, Armin Walser, Pavel Safar, Alena Stierandova
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:931-953
The invention provides compounds which specifically inhibit factor Xa activity. The compounds consist of the structure X1 -YIR-X2, wherein X1 is H, acyl, alkyl, acylalkyl, arylalkyl or one or more amino acids, and X2 is a modified C-terminal group, o
Autor:
Fahad Al-Obeidi, James A. Ostrem
Publikováno v:
Drug Discovery Today. 3:223-231
A high-priority goal in the search for new antithrombotic agents is the identification of small-molecule compounds that selectively inhibit the blood coagulation Factor Xa. These compounds should limit blood loss while controlling thrombosis followin
Publikováno v:
Biopolymers. 47:197-223
Protein tyrosine kinases (PTKs) play a crucial role in many cell regulatory processes. It is therefore not surprising to see that functional perturbation of PTKs results in many diseases. Despite the diverse primary structure organization of various
Autor:
Wildgoose P, James A. Ostrem, D. Thorpe, Lebl M, Fahad Al-Obeidi, Spoonamore J, Cross Mt, Safarova A, Stringer Sk, Patek M, Pavel Safar, Sepetov N, Strop P, Kasireddy P, LoCascio Jc
Publikováno v:
Biochemistry. 37:1053-1059
A series of low molecular weight peptide inhibitors of factor Xa, unrelated to any previously described, was identified by screening a combinatorial peptide library composed of L-amino acids. The minimal inhibitory sequence is a tripeptide, L-tyrosin
Publikováno v:
ChemInform. 30
Publikováno v:
Biochemical Journal. 268:249-262
A central goal in peptide and protein research is the development of rational approaches to the design of peptide and protein ligands with specific physical, chemical, and biological properties. In the case of peptide ligands which generally act by i
Publikováno v:
Molecular biotechnology. 9(3)
Various techniques for generation of peptide and peptidomimetic libraries are summarized in this article. Multipin, tea bag, and split-couple-mix techniques represent the major methods used to make peptides and peptidomimetics libraries. The synthesi