Zobrazeno 1 - 10
of 28
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Publikováno v:
Acta Neuropathologica. 101:491-498
Metachromatic leukodystrophy of humans is an inherited sulfatide lipidosis due to deficiency of arylsulfatase A (ASA). As an animal model, ASA(-/-) mice have been generated. A previous study showed that the mice lose most of their spiral (acoustic) g
Publikováno v:
Virchows Archiv. 439:90-96
The inherited deficiency of arylsulfatase A (ASA) in humans causes lysosomal accumulation of sulfatides in visceral organs and in the nervous system and leads to wide-spread demyelination (metachromatic leukodystrophy, MLD). ASA-deficient mice have p
Autor:
Paul Saftig, Judith Blanz, Renate Lüllmann-Rauch, Markus Damme, Jens Fogh, Stijn Stroobants, Torben Lübke, Steven U. Walkley, Rudi D'Hooge
Publikováno v:
Journal of Neuropathology and Experimental Neurology; Vol 70
α-Mannosidosis is a rare lysosomal storage disease with accumulation of undegraded mannosyl-linked oligosaccharides in cells throughout the body, most notably in the CNS. This leads to a broad spectrum of neurological manifestations, including progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afead0ac3237869ee51b551a9725d72c
https://doi.org/10.1097/nen.0b013e31820428fa
https://doi.org/10.1097/nen.0b013e31820428fa
Publikováno v:
Acta neuropathologica. 108(4)
Inherited deficiency for the lysosomal enzyme arylsulfatase A (ASA) leads to lysosomal storage of sulfatides and to dramatic demyelination in the CNS of humans (metachromatic leukodystrophy, MLD). As an animal model, ASA(-/-) mice have previously bee
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 50(4-6)
Summary Dicationic amphiphilic drugs such as the immunomodulator tilorone {2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one} are accumulated in lysosomes and disturb the degradation of sulphated glycosaminoglycans (GAGs) thus leading to generalized lyso
Publikováno v:
Experimental and Molecular Pathology. 49:279-289
The dicationic amphiphilic compound tilorone was previously shown to interfere with the lysosomal degradation of sulfated glycosaminoglycans (GAGs) of cultured cells and to cause mucopolysaccharidosis-like alterations in several organs of rats. Since
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Acta Neuropathologica. 29:237-249
Prolonged treatment of rats with the anorectic drug chlorphentermine or the tricyclic antidepressants iprindole and 1-chloro-amitriptyline caused the formation of numerous cytoplasmic inclusions in nerve cells of the cervical spinal cord and cerebell
Publikováno v:
Virchows Archiv B Cell Pathology. 11:167-181
After chronic administration of the anorectic drug Chlorphentermine the alveolar spaces of rat pulmonary tissue are filled with huge, free “foam cells”, which disappear after discontinuing the drug treatment. Ultrastructurally, these cells are he
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Virchows Archiv B Cell Pathology. 12:295-302
Chlorphentermine, an anorectic drug, was administered to pregnant rats during the second half of gravidity. In pulmonary and cardiac tissues of the corresponding foetuses ultrastructural alterations were observed, which closely resembled those previo
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Cell and tissue research. 169(4)
Rats were treated with several amphiphilic, cationic compounds that are known to cause generalized lipidosis (chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine). After prolonged drug treatment the neurohypophysis showed severe morphol