Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Hasim Bakbak, Erolcan Sayar, Harsimar B. Kaur, Daniela C. Salles, Radhika A. Patel, Jessica Hicks, Tamara L. Lotan, Angelo M. De Marzo, Roman Gulati, Jonathan I. Epstein, Michael C. Haffner
Publikováno v:
Human Pathology. 130:18-24
Genomic studies have demonstrated a high level of intra-tumoral heterogeneity in prostate cancer. There is strong evidence suggesting that individual tumor foci can arise as genetically distinct, clonally independent lesions. However, recent studies
Autor:
Jin-Yih Low, Minjeong Ko, Brian Hanratty, Radhika A. Patel, Akshay Bhamidipati, Christopher M. Heaphy, Erolcan Sayar, John K. Lee, Shan Li, Angelo M. De Marzo, William G. Nelson, Anuj Gupta, Srinivasan Yegnasubramanian, Gavin Ha, Jonathan I. Epstein, Michael C. Haffner
Publikováno v:
The American journal of pathology. 193(1)
Basal cell carcinoma (BCC) of the prostate is a rare tumor. Compared with the more common acinar adenocarcinoma (AAC) of the prostate, BCCs show features of basal cell differentiation and are thought to be biologically distinct from AAC. The spectrum
Autor:
Lorelei A. Mucci, Alan K. Meeker, Edward Giovannucci, Meir J. Stampfer, Reza Zarinshenas, Angelo M. De Marzo, Elizabeth A. Platz, Misop Han, Tamara L. Lotan, Christine Davis, Corinne E. Joshu, Jiayun Lu, John R. Barber, Christopher M. Heaphy
Publikováno v:
The journal of pathology. Clinical research. 8(5)
PurposeCurrent biomarkers are inadequate prognostic predictors in localized prostate cancer making treatment decision-making challenging. Previously, we observed that the combination of more variable telomere length among prostate cancer cells and sh
Autor:
David Lim, Mindy K. Graham, Eva Corey, Tamara L. Lotan, Jonathan I. Epstein, Alan K. Meeker, Christopher M. Heaphy, Hao Wang, Mario A. Eisenberger, Angelo M. De Marzo, Christine Davis, Michael C. Haffner
Publikováno v:
Hum Pathol
BACKGROUND: Small cell neuroendocrine carcinoma (SCNC) of the prostate is an aggressive subtype with frequent TP53 mutation and RB1 inactivation, however the molecular phenotype remains an area of investigation. Here, we compared telomere lengths in
Autor:
Qizhi Zheng, Angelo M. De Marzo, Jiayu Chen, Avi Z. Rosenberg, Michael C. Haffner, Busra Ozbek, Lauren B. Peiffer, Moshe Levi, Jessica L. Hicks, Srinivasan Yegnasubramanian, Javier A. Baena Del Valle, Xiaoxin X. Wang
Publikováno v:
Am J Pathol
Mitochondria regulate ATP production, metabolism, and cell death. Alterations in mitochondrial DNA (mtDNA) sequence and copy number are implicated in aging and organ dysfunction in diverse inherited and sporadic diseases. Because most measurements of
Autor:
Jessica L. Hicks, Tamara L. Lotan, Angelo M. De Marzo, Ayanna M Carter, Lauren B. Peiffer, Luke Mummert, Rebecca Y Sosa, Jiayun Lu, Corinne E. Joshu, Karen S. Sfanos, Ryan Kempski, Igor Vidal, Tamirat Ali, Janielle P. Maynard
Publikováno v:
J Pathol
Prostate cancer (PCa) remains a leading cause of cancer-related deaths in American men and treatment options for metastatic PCa are limited. There is a critical need to identify new mechanisms that contribute to PCa progression, that distinguish beni
Autor:
Angelo M. De Marzo, Tamara L. Lotan, Michael C. Haffner, Jun Luo, Alba Torres, Srinivasan Yegnasubramanian, Juhyung Woo, Ilsa Coleman, Thiago Vidotto, Brian Hanratty, Kaushal Asrani, Peter S. Nelson, Harrison Tsai, Eva Corey
Publikováno v:
J Pathol
Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC-adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosi
Autor:
Tamara L. Lotan, John R. Barber, Edward M. Schaeffer, Laneisha Maldonado, Angelo M. De Marzo, Corinne E. Joshu, Liana B. Guedes, Mario A. Eisenberger, Jiayun Lu, Harsimar B. Kaur, Scott A. Tomlins, Karen S. Sfanos, Logan Reitz
Publikováno v:
Hum Pathol
Summary The makeup of the tumor immune microenvironment may be associated with tumor somatic genomic alterations and plays a key role in tumor progression and response to immunotherapy. We examined the association of tumor-infiltrating T-cell density
Autor:
Heidi Hempel Sullivan, Janielle P. Maynard, Corinne E. Joshu, Tamara L. Lotan, Angelo M. De Marzo, Jiayun Lu, Christopher M. Heaphy, Karen S. Sfanos
Publikováno v:
The Journal of pathologyReferences. 253(4)
We reported previously that high numbers of mast cells in benign (extra-tumoral) regions of the prostate are associated with worse outcomes after radical prostatectomy including biochemical recurrence and the development of metastases. Herein, with a
Autor:
Janielle P. Maynard, Angelo M. De Marzo, Corey M. Porter, Karen S. Sfanos, Ibrahim Kulac, Michael C. Haffner, Javier Valle, William B. Isaacs, Srinivasan Yegnasubramanian
Publikováno v:
Am J Pathol
Lactoferrin (LTF) is an iron-binding protein canonically known for its innate and adaptive immune functions. LTF may also act as a tumor suppressor with antiproliferative action. LTF is inactivated genetically or epigenetically in various cancers, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a710a412d6ff9bc890a3ef606bfbcfb2
https://europepmc.org/articles/PMC6892185/
https://europepmc.org/articles/PMC6892185/