Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Oliver M. Sieber"'
Autor:
Catherine G Fang, Oliver M. Sieber, Nicholas J. Hawkins, Michelle Palmieri, Ian T. Jones, Iain Skinner, Peter Gibbs, Elham Amini, David Nickless, Anuratha Sakthianandeswaren, Robyn L. Ward, Dmitri Mouradov, Marsali Newman, David S. Williams, Shan Li
Publikováno v:
Modern Pathology. 33:1420-1432
Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, while tumours with ≤50% mucin are designated as having a mucinous component. However, these definitions are largely arbitr
Autor:
Ian Faragher, Dmitri Mouradov, David S. Williams, Rebecca Nightingale, Meg J. Elliott, Oliver M. Sieber, Rita Li, Peter Gibbs, Clare Browne, John M. Mariadason, Catherine G Fang, Niall C. Tebbutt, Leonid Churilov, Ian T. Jones, Michelle Palmieri
Publikováno v:
Modern Pathology. 33:483-495
TP53 mutations drive colorectal cancer development, with missense mutations frequently leading to accumulation of abnormal TP53 protein. TP53 alterations have been associated with poor prognosis and chemotherapy resistance, but data remain controvers
Autor:
Andrew Silver, Floor Aleva, Robyn L. Ward, Anil Ghosh, Pei Tian, Debbie Hampson, Ian T. Jones, Nicholas J. Hawkins, Shafi Ahmed, Robert N. Jorissen, Roger Feakins, Mohamed A. Thaha, Shan Li, Matthew Croxford, Ngaire Elwood, Neel Sengupta, David Propper, Peter L. Molloy, Nirosha Suraweera, Tom Vulliamy, Peter Gibbs, Oliver M. Sieber, Zheng Zhou Xu, Dmitri Mouradov, Michael Kirwan
Publikováno v:
Oncotarget
Telomeric dysfunction is linked to colorectal cancer (CRC) initiation. However, the relationship of normal tissue and tumor telomere lengths with CRC progression, molecular features and prognosis is unclear. Here, we measured relative telomere length
Autor:
Lise Lotte Christensen, Kristian Q Hansen, Mads Rasmussen, Rikke Hagemann-Madsen, Kasper Thorsen, Peter Gibbs, Bodil Øster, Philippe Lamy, Claus L. Andersen, Marie Stampe Ostenfeld, Søren Laurberg, Kristina Byskov, Troels Schepeler, Karin Birkenkamp-Demtroeder, Anja Holm, Oliver M. Sieber, Heidi Tobiasen, Jan Lubinski, Torben F. Ørntoft
Publikováno v:
International Journal of Cancer. 133:67-78
Colorectal cancer (CRC) is one of the leading causes of cancer deaths in Western countries. A significant number of CRC patients undergoing curatively intended surgery subsequently develop recurrence and die from the disease. MicroRNAs (miRNAs) are a
Autor:
Victoria A. Johnson, Kimberley Howarth, Mohammad Ilyas, Ashfaq Gilkar, Hanjing Yang, Andrew D. Rowan, Ian Tomlinson, Jeffrey H Miller, Christina Thirlwell, Bradley Spencer-Dene, Andrew Silver, Gordon Stamp, Oliver M. Sieber, Nikki Mandir, Robert A. Goodlad
Monoallelic APC and biallelic MYH (homolog of Escherichia coli mutY) germ-line mutations are independently associated with a strong predisposition to colorectal adenomas and carcinoma in humans. Whereas mice heterozygous for mutant Apc develop intest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa26ecb72cdc6bb7dfaee526324131c
https://ora.ox.ac.uk/objects/uuid:a1cb57ef-b2ea-4dc7-ae81-22eec8eff72f
https://ora.ox.ac.uk/objects/uuid:a1cb57ef-b2ea-4dc7-ae81-22eec8eff72f
Autor:
Ian Tomlinson, Anuratha Sakthianandeswaren, Stefania Segditsas, Robert Nicholas Jorissen, Richard J. Simpson, Matthias Ernst, Jordane Malaterre, Dustin J. Flanagan, Richard Poulsom, Francesca Walker, Nicole Church, Rosemary Jeffery, Michael Christie, Bruno Catimel, Nicholas I. Fleming, Maree C. Faux, Toby J. Phesse, Shan Li, Carla D'Andreti, Elizabeth Vincan, Peter Gibbs, Oliver K. Bernhard, Lara Lipton, Oliver M. Sieber, Cary Tsui, Robert G. Ramsay, Simon J. Leedham
Studies employing mouse models have identified crypt base and position +4 cells as strong candidates for intestinal epithelial stem cells. Equivalent cell populations are thought to exist in the human intestine; however robust and specific protein ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424de8dc4bb40d328e83deac23f543ca
https://doi.org/10.1158/0008-5472.can-10-2342
https://doi.org/10.1158/0008-5472.can-10-2342
Autor:
Rachel Langland, Jeanne Tie, Gideon Bollag, Jayesh Desai, Matthew Croxford, Ian T. Jones, K. B. Nolop, Oliver M. Sieber, Daniel McKay, Robert N. Jorissen, Michael Christie, Peter Gibbs, Suzanne Kosmider, Lara Lipton, Antony W. Burgess
Publikováno v:
International Journal of Cancer. 128:2075-2084
BRAF(V600E) mutations are found in 10% of colorectal cancers (CRCs). The low frequency of this mutation therefore makes it a challenging target for drug development, unless subsets of patients with higher rates of BRAF(V600E) can be defined. Knowledg
Autor:
Stefan Schreiber, Markus M. Lerch, Malcolm G. Dunlop, T. van Wezel, Albert Tenesa, Paul D.P. Pharoah, S. Tuupanenx, Clemens Schafmayer, Jwc Ho, Pavel Vodicka, Rodney J. Scott, Koichi Matsuda, Brent W. Zanke, Jochen Hampe, Stephan Buch, Luis G. Carvajal-Carmona, Paolo Radice, Steven Penegar, Lara Lipton, Asta Försti, Magdalena Echeverry, Henry Völzke, Ian Tomlinson, Juul T. Wijnen, Pak C. Sham, Harry Campbell, C. A. Schmidt, Antoni Castells, Robert M.W. Hofstra, Thibaud Koessler, Yusuke Nakamura, Hans Morreau, Hermann Brenner, Annika Lindblom, I. Niittymäkix, Steve Gallinger, Oliver M. Sieber, Victor Moreno, Peter Devilee, Cristina M. Villanueva, Lauri A. Aaltonen, Angel Carracedo, Peter Broderick, Sergi Castellví-Bel, Jürgen Tepel, Paolo Peterlongo, Kari Hemminki, Richard S. Houlston, Alejandro Vélez, Thomas J. Hudson, Clara Ruiz-Ponte
Publikováno v:
Tomlinson, I P M, Dunlop, M, Campbell, H, Zanke, B, Gallinger, S, Hudson, T, Koessler, T, Pharoah, P D, Niittymaki, I, Tuupanen, S, Aaltonen, L A, Hemminki, K, Lindblom, A, Forsti, A, Sieber, O, Lipton, L, van Wezel, T, Morreau, H, Wijnen, J T, Devilee, P, Matsuda, K, Nakamura, Y, Castellvi-Bel, S, Ruiz-Ponte, C, Castells, A, Carracedo, A, Ho, J W C, Sham, P, Hofstra, R M W, Vodicka, P, Brenner, H, Hampe, J, Schafmayer, C, Tepel, J, Schreiber, S, Volzke, H, Lerch, M M, Schmidt, C A, Buch, S, Moreno, V, Villanueva, C M, Peterlongo, P, Radice, P, Echeverry, M M, Velez, A, Carvajal-Carmona, L, Scott, R, Penegar, S, Broderick, P, Tenesa, A & Houlston, R S 2010, ' COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer ', British Journal of Cancer, vol. 102, no. 2, pp. 447-454 . https://doi.org/10.1038/sj.bjc.6605338
Europe PubMed Central
British journal of cancer, vol 102, iss 2
British Journal of Cancer
British Journal of Cancer, 102(2), 447-454
Recercat. Dipósit de la Recerca de Catalunya
instname
British Journal of Cancer; Vol 102
British Jounal of Cancer, 102(2), 447-454. Nature Publishing Group
Dipòsit Digital de la UB
Universidad de Barcelona
Europe PubMed Central
British journal of cancer, vol 102, iss 2
British Journal of Cancer
British Journal of Cancer, 102(2), 447-454
Recercat. Dipósit de la Recerca de Catalunya
instname
British Journal of Cancer; Vol 102
British Jounal of Cancer, 102(2), 447-454. Nature Publishing Group
Dipòsit Digital de la UB
Universidad de Barcelona
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight diff
Autor:
Christopher G. Love, Oliver M. Sieber, Peter Gibbs, Stephen McLaughlin, Zheng-Zhou Xu, Michael Christie, Nicholas J. Hawkins, Robert L. Strausberg, Shan Li, Andrew Ruszkiewicz, Dana A. Busam, Dmitri Mouradov, Lara Lipton, Peter L. Molloy, Anuratha Sakthianandeswaren, Robyn L. Ward, Qi Zhao, Jayesh Desai, Robert N. Jorissen, James Moore, Ian T. Jones, Antony W. Burgess
Publikováno v:
British Journal of Cancer
APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. APC prognostic value was evaluated in 746 stage I–IV CRC patients, stratifying for tumour location and microsatellite instability (
Autor:
Christopher Angel, Tim A. Iseli, Kendrick Koo, Michael McCullough, Antony W. Burgess, David Wiesenfeld, Oliver M. Sieber
Publikováno v:
International Journal of Oral and Maxillofacial Surgery. 44:e93-e94