Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lukasz P. Gondek"'
Autor:
Ghulam J. Mufti, Christine L. O'Keefe, Alan F. List, Anjali S. Advani, Paul Elson, Jungwon Huh, Azim M Mohamedali, Michael A. McDevitt, Mikkael A. Sekeres, Ramon V. Tiu, Jaroslaw P. Maciejewski, Ronald Paquette, Austin G. Kulasekararaj, Lukasz P. Gondek
Publikováno v:
Blood. 117:4552-4560
Single nucleotide polymorphism arrays (SNP-As) have emerged as an important tool in the identification of chromosomal defects undetected by metaphase cytogenetics (MC) in hematologic cancers, offering superior resolution of unbalanced chromosomal def
Autor:
Marcin W. Wlodarski, Mikkael A. Sekeres, Ramon V. Tiu, Jaroslaw P. Maciejewski, Karl S. Theil, Lukasz P. Gondek, Abdo Haddad, Christine L. O'Keefe
Publikováno v:
Experimental Hematology. 35:1728-1738
Objectives Using metaphase cytogenetics (MC), chromosomal defects can be detected in 40% to 60% of patients with myelodysplastic syndromes (MDS); cytogenetic results have a major impact on prognosis. We hypothesize that more precise methods of chromo
Autor:
Anna M. Jankowska, Ghulam J. Mufti, Christine L. O'Keefe, Denise A.S. Batista, Michael A. McDevitt, Azim M Mohamedali, Hideki Makishima, Lukasz P. Gondek, Bartlomiej Przychodzen, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Ramon V. Tiu, Andres Jerez
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(12)
Purpose Interstitial deletions of chromosome 5q are common in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), pointing toward the pathogenic role of this region in disease phenotype and clonal evolution. The higher level of resoluti
Autor:
Jungwon Huh, Mark J. Levis, Judith E. Karp, Xiao Fei Wang, Paul Elson, Ramon V. Tiu, Jaroslaw P. Maciejewski, Lukasz P. Gondek, Christine L. O'Keefe, Mikkael A. Sekeres, Michael A. McDevitt, Anjali S. Advani
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 27(31)
Purpose Cytogenetics is the primary outcome predictor in acute myeloid leukemia (AML). Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of patients with AML, however. Single nucleotide polymorphism arrays (SNP-A) can detect acqu
Autor:
Karl S. Theil, Lukasz P. Gondek, Christine L. O'Keefe, Ramon V. Tiu, Jaroslaw P. Maciejewski, Mikkael A. Sekeres
Publikováno v:
Blood. 111(3)
Using metaphase cytogenetics (MC), chromosomal abnormalities are found in only a proportion of patients with myelodysplastic syndrome (MDS). We hypothesized that with new precise methods more cryptic karyotypic lesions can be uncovered that may show
Autor:
Mikkael A. Sekeres, Ramon V. Tiu, B. Bhatnagar, Lukasz P. Gondek, Christine O’Keefe, J. Maciejewski, Jungwon Huh, Anjali S. Advani
Publikováno v:
Journal of Clinical Oncology. 27:7016-7016
7016 Background: Myeloproliferative disorders (MPD) and myelodysplastic syndromes (MDS) often have overlapping features resulting in unclassifiable cases (MDS-U and MDS/MPD-U). Chromosomal abnormalities impact prognosis, but 50% of cases show normal
Autor:
Ramon V. Tiu, Sanjay R. Mohan, Jungwon Huh, Marcin W. Wlodarski, Lukasz P. Gondek, Jaroslaw P. Maciejewski, Michael J. Clemente
Publikováno v:
Blood. 112:443-443
Aplastic anemia (AA) is characterized by pancytopenia due to contraction/destruction of stem cell compartment. Most investigators consider the presence of clonal cytogenetic abnormalities as incompatible with the AA diagnosis. Despite excellent respo
Autor:
Andrew Dunbar, Hideki Makishima, Michael A. McDevitt, Ramon V. Tiu, Judith E. Karp, Xiao-Fei Wang, Mark J. Levis, Christine L. O'Keefe, Jaroslaw P. Maciejewski, Lukasz P. Gondek
Publikováno v:
Blood. 112:3657-3657
Chronic myelomonocytic leukemia (CMML) patients display poor prognosis with median survival of 20 months (range 10–60). The WHO classification recognizes CMML as an overlap syndrome with mixed clinical and histomorphological features of both myelod
Autor:
Jaroslaw P. Maciejewski, Ramon V. Tiu, Xiao-Fei Wang, Christine L. O'Keefe, Michael A. McDevitt, Mark J. Levis, Lukasz P. Gondek, Judith E. Karp, Bhavana Bhatnagar, Mikkael A. Sekeres
Publikováno v:
Blood. 112:431-431
Cytogenetics is the most important predictor of outcomes in AML. Traditional metaphase cytogenetics (MC), can detect abnormalities in only 40–60% of AML patients. Whole genome scanning by single nucleotide polymorphism arrays (SNP-A) can identify s
Autor:
Jaroslaw P. Maciejewski, Lukasz P. Gondek, Theodore Ghazal, Karl S. Theil, Abdo Haddad, Mikkael A. Sekeres, Alan E. Lichtin
Publikováno v:
Blood. 110:4132-4132
Among WHO low-risk categories of MDS, refractory anemia with ringed sideroblasts (RARS) can be more accurately diagnosed by characteristic pathomorphology. Clonal hematopoiesis and chromosomal abnormalities exemplify a close pathogenetic relationship