Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elaine Bignell"'
Autor:
Daniel A. Henk, Elaine Bignell, Heiman F. L. Wertheim, William C. Nierman, Kwok-Yung Yuen, Matthew C. Fisher, Po-Ren Hsueh, Nongnuch Vanittanakom, Alex Andrianopoulos, Tran P M Sieu, Natalie D. Fedorova, Khuraijam Ranjana Devi, Kylie J. Boyce, Nguyen Van Kinh, Stephen Baker, Jeremy N. Day, Revital Shahar-Golan, Nengyong Zhan
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002851 (2012)
PLoS Pathogens
PLoS Pathogens
Molecular genetic approaches typically detect recombination in microbes regardless of assumed asexuality. However, genetic data have shown the AIDS-associated pathogen Penicillium marneffei to have extensive spatial genetic structure at local and reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded5e2a1b7a9aa9947c9fd594bb25cf9
https://ora.ox.ac.uk/objects/uuid:d6fb19c5-53ae-4c05-8f39-61b13072aab3
https://ora.ox.ac.uk/objects/uuid:d6fb19c5-53ae-4c05-8f39-61b13072aab3
Autor:
Thomas R. Rogers, Herbert N. Arst, Susana Negrete-Urtasun, Ana Maria Calcagno, Ken Haynes, Elaine Bignell
Publikováno v:
Infection and Immunity. 73:5204-5207
While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47 phox −/− mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of
Autor:
Darius Armstrong-James, Maryam Safari, Hong Liu, Elaine Bignell, Markus Schrettl, Angela M. Cheverton, Carol A. Munro, Dan Chen, Alberto Muñoz, Natalie D. Fedorova, Shinobu Saijo, Louise A. Walker, Timothy C. Cairns, Susanne Herbst, Scott G. Filler, Margherita Bertuzzi, William C. Nierman, Hubertus Haas, Eduardo A. Espeso, Laura Alcazar-Fuoli, Nick D. Read
Publikováno v:
Bertuzzi, M; Schrettl, M; Alcazar-Fuoli, L; Cairns, TC; Muñoz, A; Walker, LA; et al.(2014). The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathogens, 10(10). doi: 10.1371/journal.ppat.1004413. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3tv284s0
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS pathogens, vol 10, iss 10
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 10, no. 10 . https://doi.org/10.1371/journal.ppat.1004413
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 11, no. 6, e1004943 . https://doi.org/10.1371/journal.ppat.1004413
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS pathogens, vol 10, iss 10
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 10, no. 10 . https://doi.org/10.1371/journal.ppat.1004413
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 11, no. 6, e1004943 . https://doi.org/10.1371/journal.ppat.1004413
20 p.-8 fig. Margherita Bertuzzi et alt.
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6448d726f776ee22968ded767e73646
http://www.escholarship.org/uc/item/3tv284s0
http://www.escholarship.org/uc/item/3tv284s0
Autor:
Sean Doyle, Karen A. O'Hanlon, Sinead M. Miggin, Kevin Kavanagh, Markus Schrettl, Timothy C. Cairns, Deirdre Stack, Grainne O'Keeffe, Elaine Bignell, Thomas Ostenfeld Larsen
Publikováno v:
O'Hanlon, K, Cairns, T, Stack, D, Schrettl, M, Bignell, E M, Kavanagh, K, Miggin, S M, O'Keeffe, G, Larsen, T O & Doyle, S 2011, ' Targeted Disruption of Non-Ribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus ', Infection and Immunity, vol. 79, no. 10, pp. 3978-3992 . https://doi.org/10.1128/IAI.00192-11
Non-ribosomal peptide synthesis (NRPS) is a documented virulence factor for the opportunistic pathogen A. fumigatus, and other fungi. Secreted or intracellularly located NRP products include the toxic molecule gliotoxin and the iron-chelating siderop
A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence
Publikováno v:
Infection and immunity. 77(9)
Virulence of the fungal pathogen Aspergillus fumigatus is in part based on the saprophytic lifestyle that this mold has evolved. A crucial function for saprophytism resides in secreted proteases that allow assimilation of proteinaceous substrates. Th
Autor:
Darius Armstrong-James, Yan Yu, Hubertus Haas, Natalie D. Fedorova, Elaine Bignell, Stanley Kim, Ken Haynes, Omar Loss, Dan Chen, Gustavo H. Goldman, Jonathan Crabtree, Andrew McDonagh, Timothy C. Cairns, Markus Schrettl, Gregory S. May, William C. Nierman
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 4, Iss 9, p e1000154 (2008)
PLoS Pathogens, Vol 4, Iss 9, p e1000154 (2008)
Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled spores in the human lung causing aspergillosis, a significant threat to human health in the
Autor:
Claudia Kragl, Herbert N. Arst, Markus Schrettl, Omar Loss, Hubertus Haas, Anja Wallner, Yasmin Sabiha, Ken Haynes, Elaine Bignell, Martin Eisendle
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 3, Iss 9, Pp 1195-1207 (2007)
PLoS Pathogens, Vol 3, Iss 9, Pp 1195-1207 (2007)
Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen. We have previously demonstrated that
Autor:
Elaine Bignell, Nick D. Read, Angela M. Cheverton, Darius Armstrong-James, Eduardo A. Espeso, Markus Schrettl, Scott G. Filler, Louise A. Walker, Dan Chen, Susanne Herbst, Carol A. Munro, William C. Nierman, Laura Alcazar-Fuoli, Natalie D. Fedorova, Alberto Muñoz, Timothy C. Cairns, Margherita Bertuzzi, Hong Liu, Hubertus Haas, Shinobu Saijo, Maryam Safari
Publikováno v:
PLoS Pathogens
PLoS pathogens, vol 11, iss 6
PLoS Pathogens, Vol 11, Iss 6, p e1004943 (2015)
e1004943
PLoS pathogens, vol 11, iss 6
PLoS Pathogens, Vol 11, Iss 6, p e1004943 (2015)
e1004943
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking indivi