Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jingwu Xie"'
Publikováno v:
Cells, Vol 10, Iss 8, p 2030 (2021)
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle
Externí odkaz:
https://doaj.org/article/8617d484d6214947ba2fa40478ec4901
Autor:
Dongsheng Gu, Hai Lin, Xiaoli Zhang, Qipeng Fan, Shaoxiong Chen, Safi Shahda, Yunlong Liu, Jie Sun, Jingwu Xie
Publikováno v:
Cancers, Vol 10, Iss 11, p 403 (2018)
Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is one of the most lethal cancer types, with an estimated 44,330 death in 2018 in the US alone. While targeted therapies and immune checkpoint inhibitors have significantly improved t
Externí odkaz:
https://doaj.org/article/830fde7d13b34a008e3b8bb08e4b2616
Autor:
E. Gabriela Chiorean, Jingwu Xie, Dongsheng Gu, Beiqin Yu, Jun Wan, Xiaoli Zhang, Yanfei Jia, Yunshan Wang
Publikováno v:
Oncogene
Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most lethal cancers, with a dismal median survival around 8 months. PDAC is notoriously resistant to chemotherapy. Thus far, numerous attempts using novel targeted ther
Publikováno v:
Cells, Vol 10, Iss 2030, p 2030 (2021)
Cells
Cells
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle
Autor:
Dongsheng Gu, Xiaoben Liu, Seung Young Lee, Samuel Chen, Bing Song, Jingwu Xie, Shovik Bandyopadhyay, Stephen F. Konieczny, Junjie Li, Ji-Xin Cheng, Timothy L. Ratliff
Publikováno v:
Oncogene
Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumula
Publikováno v:
Journal of Biomedical Research
Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is a leading cause of cancer-related death in the US, with a dismal median survival of 6 months. Thus, there is an urgent unmet need to identify ways to diagnose and to treat this dea
Autor:
Robert E. Emerson, Andrea Caperell-Grant, Kiyotaka Hitomi, Jingwu Xie, Daniela Matei, Salvatore Condello, Jiyoon Lee, Bakhtiyor Yakubov
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(19)
Purpose: Aggressive pancreatic cancer is commonly associated with a dense desmoplastic stroma, which forms a protective niche for cancer cells. The objective of the study was to determine the functions of tissue transglutaminase (TG2), a Ca2+-depende
Autor:
Jayne M. Silver, Murray Korc, Brian P. McCarthy, Anthony L. Sinn, Amanda A. Riley, Harlan E. Shannon, Mark R. Kelley, Karen E. Pollok, Dongsheng Gu, Paul R. Territo, Jingwu Xie, Helmut Hanenberg, Melissa L. Fishel, Kacie M. Peterman
Publikováno v:
Pancreas. 44(1)
The purpose of the present study was to develop and validate noninvasive bioluminescence imaging methods for differentially monitoring primary and abdominal metastatic tumor growth in mouse orthotopic models of pancreatic cancer.A semiautomated maxim
Autor:
Dongsheng Gu, Hailan Liu, Xiaoli Zhang, Helen Chin-Sinex, Harlan E. Shannon, Marc S. Mendonca, Helmut Hanenberg, Jingwu Xie, Gloria H. Su, E. Gabriela Chiorean
Publikováno v:
Molecular cancer therapeutics. 12(6)
Pancreatic cancer often presents in advanced stages and is unresponsive to conventional treatments. Thus, the need to develop novel treatment strategies for pancreatic cancer has never been greater. Here, we report that combination of focal irradiati
Publikováno v:
Cancer Research. 76:4673-4673
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies, with a dismal median survival of 6 months. While combining albumin-bound paclitaxel with gemcitabine has shown clear therapeutic advantage, numerous attempts using