Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ajay P. Singh"'
Publikováno v:
J Cell Biochem
Pancreatic tumors are highly desmoplastic and poorly-vascularized, and therefore must develop adaptive mechanisms to sustain their survival under hypoxic condition. Extracellular vesicles (EV) play vital roles in pancreatic tumor pathobiology by faci
Autor:
Sanjeev K. Srivastava, Suhash Reddy Chavva, Nikhil Tyagi, Seema Singh, Ajay P. Singh, Sachin Kumar Deshmukh, Girijesh Kumar Patel, Rajashekhar Kanchanapally
Publikováno v:
International Journal of Nanomedicine
Rajashekhar Kanchanapally,1 Sachin Kumar Deshmukh,1 Suhash Reddy Chavva,1 Nikhil Tyagi,1 Sanjeev Kumar Srivastava,1 Girijesh Kumar Patel,1 Ajay Pratap Singh,1,2 Seema Singh1,2 1Department of Oncologic Sciences, Mitchell Cancer Institute, University o
Autor:
Gregory S. Gorman, Ajay P. Singh, Sanjeev K. Srivastava, James E. Carter, Mohammad Aslam Khan, Haseeb Zubair, Girijesh Kumar Patel, Seema Singh, Sumit Arora, Moh’d Khushman
Publikováno v:
J Biol Chem
Pancreatic cancer (PC) remains a therapeutic challenge because of its intrinsic and extrinsic chemoresistance mechanisms. Here, we report that C-X-C motif chemokine receptor 4 (CXCR4) and hedgehog pathways cooperate in PC chemoresistance via bidirect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d342dbc0475a567fe69630669ace0c5
https://europepmc.org/articles/PMC7307206/
https://europepmc.org/articles/PMC7307206/
Autor:
Mohammad Aslam Khan, Arun Bhardwaj, Haseeb Zubair, Moh’d Khushman, Seema Singh, Girijesh Kumar Patel, Mary C. Patton, Sanjeev K. Srivastava, Ajay P. Singh
Publikováno v:
British Journal of Cancer
Background: Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresi
Autor:
James E. Carter, Sanjeev K. Srivastava, Sumit Arora, Shafquat Azim, Seema Singh, Arun Bhardwaj, Ajay P. Singh, Nikhil Tyagi, Bin Wang
Publikováno v:
British Journal of Cancer
Background: MYB encodes for a transcription factor regulating the expression of a wide array of genes involved in cellular functions. It is reported to be amplified in a sub-set of pancreatic cancer (PC) cases; however, its pathobiological associatio
Autor:
Ajay P. Singh, Mohammad Aslam Khan, Seema Singh, Sanjeev K. Srivastava, Rajashekhar Kanchanapally, Sachin Kumar Deshmukh
Publikováno v:
Cancer Research. 80:6259-6259
Pancreatic cancer (PC) is the third leading cause of cancer-related death in the United States. It is challenging to treat PC due to the existence of intrinsic and extrinsic chemoresistance mechanisms. We previously reported that honokiol, a phytoche
Publikováno v:
Cancer Research. 80:2601-2601
Rab proteins form the largest subfamily of small GTPases and play an indispensable role in the regulation of vesicle trafficking. They control a wide variety of endocytic, transcytic and exocytic transport pathways and thus play important roles in ce
Autor:
Mohammad Aslam Khan, Santanu Dasgupta, Seema Singh, Ajay P. Singh, Moh’d Khushman, Shashi Anand
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5580, p 5580 (2020)
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5580, p 5580 (2020)
RAB proteins (RABs) represent the largest subfamily of Ras-like small GTPases that regulate a wide variety of endosomal membrane transport pathways. Their aberrant expression has been demonstrated in various malignancies and implicated in pathogenesi
Autor:
Nikhil Tyagi, Seema Singh, Ahmed Al-Ghadhban, James E. Carter, Mohammad Aslam Khan, Kari Dugger, Ajay P. Singh, Sanjeev K. Srivastava, Sachin Kumar Deshmukh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Chemotherapy-induced immunosuppression poses an additional challenge to its limited efficacy in pancreatic cancer (PC). Here we investigated the effect of gemcitabine on macrophages, which are the first line of immune-defense mechanisms. We observed
Autor:
Sanjeev K. Srivastava, Bin Wang, Ahmed Al-Ghadhban, Seema Singh, James E. Carter, Nikhil Tyagi, Shafquat Azim, Sachin Kumar Deshmukh, Ajay P. Singh, Aamir Ahmad
The ETS family transcription factor ETV4 is aberrantly expressed in a variety of human tumors and plays an important role in carcinogenesis through upregulation of relevant target gene expression. Here, it is demonstrated that ETV4 is overexpressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf8bb8b93f2c0e1d0a5bff3f7b23a09
https://europepmc.org/articles/PMC5805611/
https://europepmc.org/articles/PMC5805611/