Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Almudena Porras"'
Autor:
Paloma Bragado, Almudena Porras, Massimo Pancione, Luigi Cerulo, Andrea Remo, Guido Giordano, Alvaro Gutierrez-Uzquiza
Publikováno v:
Biomolecules, Vol 11, Iss 629, p 629 (2021)
Biomolecules
Biomolecules
Metastasis is a process by which cancer cells escape from the location of the primary tumor invading normal tissues at distant organs. Chromosomal instability (CIN) is a hallmark of human cancer, associated with metastasis and therapeutic resistance.
Autor:
Almudena Porras, Celia Sequera, Ana Vázquez-Carballo, María Arechederra, Sonia Fernández-Veledo
Publikováno v:
Journal of Cellular Physiology. 233:968-978
TWEAK regulates multiple physio-pathological processes in fibroblasts such as fibrosis. It also induces migration and invasion in tumors and it can activate p38 MAPK in various cell types. Moreover, p38α MAPK promotes migration and invasion in sever
Autor:
Susana Zuluaga, Manuel Benito, Almudena Porras, Alvaro Gutierrez-Uzquiza, Angel R. Nebreda, Alberto Álvarez-Barrientos, Paloma Bragado
Publikováno v:
FEBS Letters. 581:3819-3825
The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulat
Publikováno v:
Apoptosis. 12:1733-1742
Cisplatin is one of the major chemotherapeutic weapons used against different human cancers, although its mechanism to induce apoptosis is not fully understood. The presence of wild type p53 has been suggested to be important for cisplatin cytotoxici
Autor:
Ramón Muñoz-Chápuli, Aránzazu Sánchez, José M. López-Novoa, Almudena Porras, Carmen Guerrero, Michael D. Schneider, Elena Cano, Flavio Maina, Paloma Bragado, Ignacio Cruz-González, Rita Carmona, Alvaro Gutierrez-Uzquiza, María González-Núñez, María Arechederra
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
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Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
et al.
Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling
Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling
Autor:
Fernando Rodríguez-Pascual, Natalia Romero, Cristina de Álvaro, Rosa Bretón-Romero, Almudena Porras, João Laranjinha, Rafael Radi, Francisco J. Sánchez-Gómez, Santiago Lamas, Cecilia González de Orduña
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Laminar shear stress (LSS) is a protective hemodynamic regulator of endothelial function and limits the development of atherosclerosis and other vascular wall diseases related to pathophysiological generation of reactive oxygen species. LSS activates
Autor:
Alvaro Gutierrez-Uzquiza, Carmen Guerrero, Rocío Baños, Manuel Benito, Isabel Molina, Almudena Porras, María Arechederra, Vera Maia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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We present here evidences supporting a negative regulation of p38α MAPK activity by C3G in MEFs triggered by stress, which can mediate cell death or survival depending on the stimuli. Upon serum deprivation, C3G induces survival through inhibition o
Autor:
Almudena Porras, Alberto de Luis, Carmen Guerrero, Alvaro Gutierrez-Uzquiza, Javier Gutierrez-Berzal, María Adelaida Andrés Sanz, Vera Maia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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In this work we report evidences of a functional relationship between C3G and p38 MAPK in the apoptotic effect of STI-571 on the chronic myeloid leukemia (CML) cell line K562. This has been demonstrated by knocking down C3G and p38α using the interf
Autor:
Andreas Pilz, Almudena Porras, Katrin Ramsauer, Iwona Sadzak, Angel R. Nebreda, Pavel Kovarik, Thomas Decker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(20)
The transcription factor signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Tyr-701 and Ser-727 for full activation. IFN-gamma induces phosphorylation of both residues, whereas stress signals like UV or lipopo
Autor:
Almudena Porras, Blanca Herrera, Isabel Fabregat, Margarita Fernández, Amparo Valladares, Manuel Benito, Juan-Jose Ventura, César Roncero
Publikováno v:
FEBS letters. 499(3)
We have previously found that transforming growth factor-beta (TGF-beta) induces an increase in radical oxygen species (ROS) production that mediates its apoptotic effects in fetal hepatocytes. In this paper we show that TGF-beta activates p38 mitoge