Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Xiaofeng Tian"'
Autor:
Yue Wang, Yan Zhao, Zhecheng Wang, Ruimin Sun, Boyang Zou, Ruixi Li, Deshun Liu, Musen Lin, Junjun Zhou, Shili Ning, Xiaofeng Tian, Jihong Yao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Pyroptosis is a newly discovered form of cell death. Peroxiredoxin 3 (PRX3) plays a crucial role in scavenging reactive oxygen species (ROS), but its hepatoprotective capacity in acetaminophen (APAP)-induced liver disease remains unclear. The aim of
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species
Autor:
Zhenming Gao, Xiaofeng Tian, Zhecheng Wang, Li Lv, Dongcheng Feng, Huanyu Zhao, Ning Zhang, Yan Hu, Xiaohan Zhai, Jihong Yao, Yan Zhao, Musen Lin
Publikováno v:
Theranostics
Background: p66Shc is a redox enzyme that mediates mitochondrial reactive oxygen species (ROS) generation. p66Shc inhibition confers protection against liver injury, however, its functional contribution to liver fibrosis remains unclear. The aim of t
Autor:
Yan Zhao, Musen Lin, Deshun Liu, Yu Sun, Zhao Chen, Ruimin Sun, Jihong Yao, Junjun Zhou, Zhecheng Wang, Li Lv, Xiaofeng Tian
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 11, Pp 1-15 (2020)
Cell Death and Disease, Vol 11, Iss 11, Pp 1-15 (2020)
p66Shc, a master regulator of mitochondrial reactive oxygen species (mtROS), is a crucial mediator of hepatocyte oxidative stress. However, its functional contribution to acetaminophen (APAP)-induced liver injury and the mechanism by which it is modu
Autor:
Yan Zhao, Yu Sun, Huanyu Zhao, Zhecheng Wang, Yunfei Geng, Meiyang Zhu, Ruimin Sun, Jihong Yao, Xiaofeng Tian, Xiaohui Kang, Yue Wang, Yan Hu
Publikováno v:
Toxicology and Applied Pharmacology. 432:115758
Mitochondrial dysfunction is a major factor in nonalcoholic fatty liver disease (NAFLD), preceding insulin resistance and hepatic steatosis. Carnosol (CAR) is a kind of diterpenoid with antioxidant, anti-inflammatory and antitumor activities. Peroxir
Autor:
Yan Zhao, Yan Hu, Zhao Chen, Yang Li, Shili Ning, Jihong Yao, Zhecheng Wang, Deshun Liu, Xiaofeng Tian, Dongcheng Feng
Publikováno v:
Theranostics
Background: Oxidative stress has emerged as an essential factor in the pathogenesis of intestinal ischemia/reperfusion (I/R) injury. The adaptor protein p66Shc is a key regulator of reactive oxygen species (ROS) generation and a mediator of I/R damag
Autor:
Deshun Liu, Yan Zhao, Ruimin Sun, Jihong Yao, Huanyu Zhao, Guangzhi Wang, Zhao Chen, Yang Li, Zhanyu Wang, Xiaofeng Tian, Feng Zhang
Publikováno v:
Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology
Redox Biology
Background: Hydrogen peroxide (H2O2)-induced mitochondrial oxidative damage is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H2O2 scavenger that protects cells from mitochondrial oxidative damage and apoptosis. H
Autor:
Zhenlu Li, Xue Shi, Anlong Ji, Chunchun Ding, Dongyan Gao, Yang Li, Junjun Zhou, Jihong Yao, Zhecheng Wang, Dongcheng Feng, Xiaofeng Tian, Yan Zhao
Publikováno v:
Toxicology and Applied Pharmacology. 350:21-31
In recent years, alcoholic liver disease (ALD) has emerged as a growing public health problem worldwide. β-catenin plays an important role in the growth, development, regeneration and metabolic activity of the liver. Salvianolic acid A (SalA) is a w
Autor:
Wasim Qasim, Xiaofeng Tian, Guangzhi Wang, Yang Li, Jihong Yao, Zhenlu Li, Fuwen Luo, Zhao Chen, Dongcheng Feng, Shili Ning, Guo Zu
Publikováno v:
Clinical Science. 131:759-773
Intestinal epithelial oxidative stress and apoptosis constitute key pathogenic mechanisms underlying intestinal ischemia/reperfusion (I/R) injury. We previously reported that the adaptor 66 kDa isoform of the adaptor molecule ShcA (p66Shc)-mediated p
Autor:
Guangzhi Wang, Zhao Chen, Ling-fei Ma, Jihong Yao, Zhenhai Ma, Zhenlu Li, Xiaofeng Tian, Shu Wang, Hong Chang, Haidong Zhao
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
The Scientific World Journal
The Scientific World Journal
Intestinal ischemia-reperfusion (I/R) injury is a serious clinical pathophysiological process that may result in acute local intestine and remote liver injury. Protocatechuic acid (PCA), which has been widely studied as a polyphenolic compound, induc
Autor:
Guangzhi Wang, Xiangwen Zhang, Jing Guo, Xiaofeng Tian, Guo Zu, Anlong Ji, Ningwei Che, Tingting Zhou
Publikováno v:
Scientific Reports
Ginsenoside Rg1 (Rg1) is one of the major bioactive ingredients in Panax ginseng, and it attenuates inflammation and apoptosis. The aims of our study were to explore the potential of Rg1 for the treatment of intestinal I/R injury and to determine whe