Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Motohiro Nishida"'
Autor:
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 562 (2022)
Although the number of patients with heart failure is increasing, a sufficient treatment agent has not been established. Oxidative stress and inflammation play important roles in the development of myocardial remodeling. When thioredoxin (Trx), an en
Externí odkaz:
https://doaj.org/article/9bfab83e4db0428c8d5f6c1cc1ed008c
Publikováno v:
YAKUGAKU ZASSHI. 138:1257-1262
Moderate exercise has been reported to combat several diseases, including cardiovascular diseases and depressants. However, many patients do not have ability to undergo exercise therapy due to aging and severity of the symptoms. Therefore development
Autor:
Kakeru, Shimoda, Akiyuki, Nishimura, Caroline, Sunggip, Tomoya, Ito, Kazuhiro, Nishiyama, Yuri, Kato, Tomohiro, Tanaka, Hidetoshi, Tozaki-Saitoh, Makoto, Tsuda, Motohiro, Nishida
Publikováno v:
Scientific Reports
Cardiac tissue remodeling caused by hemodynamic overload is a major clinical outcome of heart failure. Uridine-responsive purinergic P2Y6 receptor (P2Y6R) contributes to the progression of cardiovascular remodeling in rodents, but it is not known whe
Autor:
Hozumi Motohashi, Shigemoto Fujii, Hideshi Ihara, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of biological molecules generated by reactive oxygen species. Current redox biology is revisiting the traditional concept of oxidative stress, such that toxic effec
Autor:
Ryosuke Matsukane, Akiyuki Nishimura, Sumio Hoka, Tomoya Ito, Yasuo Mori, Sayaka Oda, Takuro Numaga-Tomita, Motohiro Nishida, Tomomi Ide, Hideki Sumimoto, Koji Uchida, Norimichi Koitabashi, Tsukasa Shimauchi
Publikováno v:
JCI Insight. 2
Myocardial atrophy is a wasting of cardiac muscle due to hemodynamic unloading. Doxorubicin is a highly effective anticancer agent but also induces myocardial atrophy through a largely unknown mechanism. Here, we demonstrate that inhibiting transient
Autor:
Shingo Kasamatsu, Takaaki Akaike, Hozumi Motohashi, Tetsuro Matsunaga, Motohiro Nishida, Akiyuki Nishimura
Publikováno v:
Free radical biologymedicine. 109
Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mai
Autor:
Caroline Sunggip, Shota Saiki, Shizuka Aritomi, Katsuya Hirano, Tatsuya Ishikawa, Motohiro Nishida, Koichiro Kuwahara, Yasuo Mori, Shokei Kim-Mitsuyama, Eri Harada
Publikováno v:
Biochemical and Biophysical Research Communications. 434(2):210-216
N-type voltage-dependent Ca2+channels (VDCCs), expressed predominantly in the nervous system, play pivotal roles in sympathetic regulation of the circulatory system. Although N-type VDCCs are also reportedly expressed in the vasculature, their pathop
Autor:
Shigemoto Fujii, Hozumi Motohashi, Tomohiro Sawa, Tomoaki Ida, Takaaki Akaike, Hideshi Ihara, Motohiro Nishida
Publikováno v:
Archives of biochemistry and biophysics. 595
Reactive oxygen (oxidant) and free radical species are known to cause nonspecific damage of various biological molecules. The oxidant toxicology is developing an emerging concept of the physiological functions of reactive oxygen species in cell signa
Autor:
Takaaki Akaike, Hidenao Kakehashi, Yoshito Kumagai, Isao Ishii, Tomoaki Ida, Motohiro Nishida, Yumi Abiko, Takashi Miura, Yasuhiro Shinkai, Tomohiro Sawa
Publikováno v:
Chemical research in toxicology. 28(5)
Sulfhydration by a hydrogen sulfide anion and electrophile thiolation by reactive sulfur species (RSS) such as persulfides/polysulfides (e.g., R-S-SH/R-S-Sn-H(R)) are unique reactions in electrophilic signaling. Using 1,2-dihydroxynaphthalene-4-thioa
Autor:
Takaaki Akaike, Tomoaki Ida, Fan-Yan Wei, Motohiro Nishida, Yoshito Kumagai, Alam, Md. Morshedul, Hideshi Ihara, Tomohiro Sawa, Tetsuro Matsunaga, Shingo Kasamatsu, Akiyuki Nishimura, Masanobu Morita, Kazuhito Tomizawa, Akira Nishimura, Watanabe, Satoshi, Inaba, Kenji, Hiroshi Shima, Nobuhiro Tanuma, Minkyung Jung, Shigemoto Fujii
Publikováno v:
Nature Communications; 10/27/2017, Vol. 8 Issue 1, p1-15, 15p