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pro vyhledávání: '"Martín, Hugo"'
Autor:
Ioanna Korovila, Martín Hugo, José Pedro Castro, Daniela Weber, Annika Höhn, Tilman Grune, Tobias Jung
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 550-567 (2017)
The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of mammalian cells, systems are
Externí odkaz:
https://doaj.org/article/75e4d02c5203422fbbe8cbcc7ce3f931
Akademický článek
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Publikováno v:
Free radical biology and medicine, 160:293-302
The proteasomal degradation system is one of the most important protein degradation systems in the cytosol and nucleus. This system is present in two major forms: the ATP-stimulated 26S/30 S proteasome or the ATP-independent 20S core proteasome. Whil
Autor:
Tobias Jung, Daniela Weber, Tilman Grune, José Pedro Castro, Ioanna Korovila, Annika Höhn, Martín Hugo
Publikováno v:
Redox Biology
Redox Biology, Vol 13, Iss C, Pp 550-567 (2017)
Redox Biology, Vol 13, Iss C, Pp 550-567 (2017)
The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of mammalian cells, systems are
Autor:
Annika Höhn, Jeannette König, Martín Hugo, Tilman Grune, Anne-Laure Bulteau, Tobias Jung, Christiane Ott
Publikováno v:
Redox Biology, Vol 11, Iss, Pp 673-681 (2017)
Redox Biology
Redox Biology
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production of ROS during the oxidative phosphorylation. The hypothesis exists that mitochondria are involved in the formation of lipofuscin,
Autor:
Tim J. Schulz, Anne Schraplau, Charles Dominic Coleman, Gerhard Püschel, Daniela Weber, Stephanie Krämer, José Pedro Castro, J Henkel, Martín Hugo, Korinna Jöhrens, Annette Schürmann
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 70-82 (2017)
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as
Autor:
Anabel Marina, Tilman Grune, Martín Hugo, Markus Köhler, Carlos García-García, Ioanna Korovila, J. Daniel Cabrera-García, Antonio Martínez-Ruiz
Publikováno v:
Redox Biology
Redox Biology, Vol 16, Iss, Pp 123-128 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology, Vol 16, Iss, Pp 123-128 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Under oxidative stress 26S proteasomes suffer reversible disassembly into its 20S and 19S subunits, a process mediated by HSP70. This inhibits the degradation of polyubiquitinated proteins by the 26S proteasome and allows the degradation of oxidized
Autor:
Madia Trujillo, Carlos Batthyány, Bruno Manta, Ana Denicola, Magdalena Gil, Lía M. Randall, Martín Hugo, Leslie B. Poole
Publikováno v:
Journal of Biological Chemistry. 289:15536-15543
Peroxiredoxins (Prx) are efficient thiol-dependent peroxidases and key players in the mechanism of H2O2-induced redox signaling. Any structural change that could affect their redox state, oligomeric structure, and/or interaction with other proteins c
Autor:
José Pedro Castro, André Kleinridders, Kerstin Nowotny, Tobias Jung, Tilman Grune, Raquel Fernando, Martín Hugo, Kristina Wardelmann
Publikováno v:
Free Radical Biology and Medicine. 108:S35
The white adipose tissue (WAT) is crucial for maintaining metabolism homeostasis by storing lipids and/or by secreting adipokines. A healthy WAT relies on continuous renewal, through a multi-step process called adipogenesis. Upon failure, the risk fo
Autor:
Leticia Prates Roma, Tilman Grune, Antonio Martínez-Ruiz, Martín Hugo, Carmen García, Ioana Korovila, Anabel Marina
Publikováno v:
Free Radical Biology and Medicine. 108:S100
The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. It is accepted that upon oxida