Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Theodore R. Holman"'
Autor:
Fatma B. Cinemre, Hülya Bayır, Rong-Rong He, Wanyang Sun, Haider H. Dar, Yulia Y. Tyurina, Indira H. Shrivastava, Theodore R. Holman, Tamil S. Anthonymuthu, Valerian E. Kagan, Yoel Sadovsky, Vladimir A. Tyurin, Karolina Mikulska-Ruminska, Ivet Bahar, Brent R. Stockwell, Andrew P. VanDemark
Publikováno v:
Redox Biology
Redox Biology, Vol 38, Iss, Pp 101744-(2021)
Redox Biology, Vol 38, Iss, Pp 101744-(2021)
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic r
Publikováno v:
Molecules, Vol 25, Iss 3374, p 3374 (2020)
Molecules
Molecules
Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzyme
Autor:
Reheman Adili, Theodore R. Holman, Pilar Fernandez-Perez, Johnny Yu, Michael Holinstat, Benjamin E. Tourdot, Cody J. Freedman, Abigail R. Green, Jennifer Yeung
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:2068-2077
Objective— Dietary supplementation with polyunsaturated fatty acids has been widely used for primary and secondary prevention of cardiovascular disease in individuals at risk; however, the cardioprotective benefits of polyunsaturated fatty acids re
Autor:
Vladimir A. Tyurin, Indira H. Shrivastava, Hülya Bayır, Gaowei Mao, David R. Emlet, Xiaoyan Wen, Andrew P. VanDemark, Simon C. Watkins, Theodore R. Holman, John A. Kellum, Tamil S. Anthonymuthu, Elizabeth M. Kenny, Alexandr A. Kapralov, Feng Qu, Valerian E. Kagan, Claudette M. St. Croix, Sally E. Wenzel, Ivet Bahar, Karolina Mikulska-Ruminska, Haider H. Dar, Yulia Y. Tyurina, Joel C. Rosenbaum, Louis J. Sparvero, Yoshinori Minami, Jinming Zhao, Qin Yang, Andrew A. Amoscato
Publikováno v:
Cell. 171:628-641.e26
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated
Autor:
Wladek Minor, Jing Zhou, Aaron T. Wecksler, Michael L. Neidig, Edward I. Solomon, Theodore R. Holman, Maksymilian Chruszcz, Erika N. Segraves, Viola Ruddat
Publikováno v:
Biochemistry. 45:10233-10242
In wild-type soybean LO-1 (WT sLO-1), Asn694 is a weak sixth ligand that is thought to becritical for enzymatic catalysis. In this investigation, N694G sLO-1 was studied to probe its contributionat this sixth ligand position to the kinetic and spectr
Autor:
Joanne F. Arguello, Robert H. Cichewicz, Victor Kenyon, Nancy M. Morales, Theodore R. Holman, Phillip Crews, Stephanie Whitman
Publikováno v:
Journal of the American Chemical Society. 126:14910-14920
The selective inhibition of human 15-lipoxygenase (15-hLO) could serve as a promising therapeutic target for the prevention of atherosclerosis. A screening of marine sponges revealed that crude extracts of Psammocinia sp. exhibited potent 15-hLO inhi
Autor:
Kaushik Ghosh, Aura A. Eroy-Reveles, Pradip K. Mascharak, Belem Avila, Theodore R. Holman, Marilyn M. Olmstead
Publikováno v:
Inorganic Chemistry. 43:2988-2997
The Mn(II) and Mn(III) complexes of the pentadentate ligand N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide (PaPy3H; H is the dissociable carboxamide H), namely, [Mn(PaPy3)(H2O)]ClO4 (1) and [Mn(PaPy3)(Cl)]ClO4 (2), with bound carboxam
Publikováno v:
Biochemistry. 40:7509-7517
Lipoxygenases are an important class of non-heme iron enzymes that catalyze the hydroperoxidation of unsaturated fatty acids. The details of the enzymatic mechanism of lipoxygenases are still not well understood. This study utilizes a combination of
Understanding the mode of action for lipoxygenase (LOX) inhibitors is critical to determining their efficacy in the cell. The pseudoperoxidase assay is an important tool for establishing if a LOX inhibitor is reductive in nature, however, there have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ddf6396816a1882b35c3636297371c
https://europepmc.org/articles/PMC3781013/
https://europepmc.org/articles/PMC3781013/
Publikováno v:
Organicbiomolecular chemistry. 6(22)
Lipoxygenases catalyse the oxidation of polyunsaturated fatty acids and have been invoked in many diseases including cancer, atherosclerosis and Alzheimer's disease. Currently, no X-ray structures are available with substrate or substrate analogues b