Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniel R Ambruso"'
Publikováno v:
European Journal of Immunology. 42:1609-1617
Peroxiredoxin 6-phospholipase A2 (Prdx6-PLA2) is a bi-functional enzyme with peroxi-redoxin (Prdx) and phospholipase A2 (PLA2) activities. To investigate its impact on phagocyte NADPH oxidase (phox) activity in a neutrophil model, the protein was kno
Autor:
Christopher C. Silliman, Marguerite R. Kelher, Gail Thurman, Steven M. Anderson, David J. Elzi, Andrew J. Paterson, Daniel R. Ambruso
Publikováno v:
Cell Calcium. 34:445-455
Chemoattractant priming and activation of PMNs results in changes in cytosolic Ca 2+ concentration, tyrosine kinase activity, and gene expression. We hypothesize that the initial signaling for the activation of a 105 kDa protein (Rel-1) requires Ca 2
Publikováno v:
Transfusion. 52:1155-1157
We read with interest the recent publication of Vlaar and colleagues,1 which detailed the accumulation of bio-active lipids during the storage of blood products and their findings that these lipids are not cell but plasma and temperature dependent. I
Autor:
Frans A. Kuypers, Stefanie Freeman, Carolina Gonzalez-Aller, Lori A. Rinckel, Patrick J. Leavey, Michael Kleinberg, Daniel W. Ambruso, Gail Thurman, Daniel R. Ambruso
Publikováno v:
Journal of Biological Chemistry. 277:45181-45187
Production of toxic oxygen metabolites provides a mechanism for microbicidal activity of the neutrophil. The NADPH oxidase enzyme system initiates the production of oxygen metabolites by reducing oxygen to form superoxide anion (O(2)()). With stimula
Publikováno v:
Transfusion. 40:414-419
BACKGROUND: Granulocyte transfusion may be used in neutropenic patients with severe bacterial or fungal infections that are unresponsive to antibiotic therapy. However, the inability to store granulocyte concentrates limits their clinical usefulness.
Autor:
Gail W. Thurman, Daniel R. Ambruso, Nancy Cusack, Verlyn M. Peterson, Joseph Rosenthal, Harry L. Malech
Publikováno v:
Blood. 88:4321-4329
Infection is a major cause of morbidity and mortality in patients after thermal injury. This predisposition to infections is related, in part, to abnormal polymorphonuclear leukocyte (PMN) function and a diminished respiratory burst. To evaluate the
Publikováno v:
Biochimica et biophysica acta. 1823(2)
Neutrophils provide the first line of defense against microbial invasion in part through production of reactive oxygen species (ROS) which is mediated through activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase generating supero
Publikováno v:
Blood. 116:926-926
Abstract 926 Introduction: An intact respiratory burst is critical to the microbial activity of neutrophils. The respiratory burst is initiated by assembly and activation of the NADPH oxidase, Nox2. We have identified a 29 kDa protein from human neut
Publikováno v:
Vox sanguinis. 63(2)
Neutrophils (PMNs) initiate production of toxic oxygen metabolites through stimulation of an NADPH oxidase resulting in the reduction of oxygen to superoxide anion (O2-). The activity of this enzyme system may be primed by a variety of compounds. Thi
Publikováno v:
Blood. 114:3592-3592
Abstract 3592 Poster Board III-529 Introduction An intact respiratory burst is critical to the microbial activity of neutrophils. The respiratory burst is initiated by assembly and activation of the NADPH oxidase. We have identified a 29 kDa protein