Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ted William Johnson"'
Autor:
Dan Gehlhaar, Alexei Brooun, Mehran Jalaie, Michele McTigue, Sergei Timofeevski, Ben Bolaños, Gallego Rebecca Anne, Ted William Johnson
Publikováno v:
ACS medicinal chemistry letters. 9(9)
[Image: see text] Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that can become oncogenic by activating mutations or overexpression. Full kinetic characterization of both phosphorylated and nonphosphorylated wildtype and mutant ALK k
[Image: see text] Structure-based drug design (SBDD) is commonly leveraged in rational drug design. Usually, ligand and binding site atomic coordinates from crystallographic data are exploited to optimize potency and selectivity. In addition to tradi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433858d7f4acc4552a7679cee53ca01a
https://europepmc.org/articles/PMC6142050/
https://europepmc.org/articles/PMC6142050/
Autor:
Paul G. Richardson, Phuong Le, Benjamin J. Burke, Ted William Johnson, Sacha Ninkovic, Ketan S. Gajiwala, Maria Angelica Linton
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3408-3413
Incorporation of nitrogen is a common medicinal chemistry tactic to reduce log D values. Neighboring group participation influences log D , so the results are isomer dependent. The log D and log P differences observed between isomeric pyrimidines 1 ,
Autor:
Simon Bailey, Cheng Hengmiao, Marlena Walls, Matthew A. Marx, Kevin K.-C. Liu, Jacqui Elizabeth Hoffman, Zhengyu Liu, Jinjiang Zhu, Lisa Guo, John Li, Lance Goulet, Peter A. Wells, Chunze Li, Ying Jiang, Daniel R. Knighton, Min-Jean Yin, Ted William Johnson, Michael Zientek, Sangita M. Baxi, Theodore O. Johnson
Publikováno v:
ACS Medicinal Chemistry Letters. 4:91-97
PI3K, AKT, and mTOR are key kinases from PI3K signaling pathway being extensively pursued to treat a variety of cancers in oncology. To search for a structurally differentiated back-up candidate to PF-04691502, which is currently in phase I/II clinic
Autor:
Qinghai Peng, Tran Khanh Tuan, Atsuo Kuki, Steven P. Tanis, Zhang Junhu, Deepak Dalvie, Yang Anle, Xiaoming Yu, Jim Solowiej, Ted William Johnson, Hai Wang, Wen Liu, Plewe Michael Bruno, Buwen Huang, Graham L. Smith, Jon E. Kuehler, Klaus Ruprecht Dress, Chunfeng Yin, Qiyue Hu, Dorothy Delisle, Huichun Zhu, Scott L. Butler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7429-7434
HIV-1 integrase is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the discovery of azaindole hydroxamic acids
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5560-5564
The Golden Triangle is a visualization tool developed from in vitro permeability, in vitro clearance and computational data designed to aid medicinal chemists in achieving metabolically stable, permeable and potent drug candidates. Classifying compou
Publikováno v:
Future Medicinal Chemistry. 5:113-115