Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mitschler A"'
Autor:
Dimitris Kletsas, Sergio Porté, F.X. Ruiz, Jaume Farrés, Joan Gimenez-Dejoz, Harris Pratsinis, Isidro Crespo, Alberto Podjarny, Kamel Metwally, Alexandra Cousido-Siah, Andre Mitschler, Xavier Parés
Publikováno v:
European journal of medicinal chemistry. 152
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to diabetes seco
Autor:
Minkoo Ji, Alberto Podjarny, Yung Lee, M. Andreoli, Erik Jagdmann, Bruce R. Conway, Ryan Sheeler, Darren Whitehouse, Czestkowski Wojciech J, Adam Golebiowski, Jacek Olczak, Andre Mitschler, Alexandra Cousido-Siah, Wieslawa Piotrowska, Todd Robert Ryder, Marzena Mazur, Michael C. Van Zandt, F.X. Ruiz, Paul Beckett, Hagen Schroeter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4837-4841
The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the previously reported series of 2-amino-6-boronohexanoic acid (ABH) analogs 1, we designed and synt
Autor:
F.X. Ruiz, Alexandra Cousido-Siah, Alberto Podjarny, Todd Robert Ryder, Erik Jagdmann, Adam Golebiowski, M. Andreoli, Michael C. Van Zandt, Darren Whitehouse, Hagen Schroeter, Paul Beckett, Adam W. Mazur, Manyian Padmanilayam, Minkoo Ji, Andre Mitschler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2027-2030
Substitution at the alpha center of the known human arginase inhibitor 2-amino-6-boronohexanoic acid (ABH) is acceptable in the active site pockets of both human arginase I and arginase II. In particular, substituents with a tertiary amine linked via
Autor:
Alberto Podjarny, Gerhard Klebe, C. Rechlin, Sergio Porté, Andre Mitschler, Xavier Parés, Alexandra Cousido-Siah, Jesús Ángel de la Fuente, Isidro Crespo, María Jesús Martín, Angel R. de Lera, Marta Domínguez, F.X. Ruiz, Jaume Farrés
Publikováno v:
ChemMedChem. 10(12)
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4
Autor:
Alberto Podjarny, Andre Mitschler, Kerry Combs, Evelyn O. Sibley, Al Sabetta, Erin E. McCann, Anne L. Carrington, Eduardo Howard, Diane R. Sawicki, Janet Sredy, Brenda R. Flam, Michael C. Van Zandt
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5661-5675
Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid aldose reductase inhibitors. The compound class features a
Autor:
F.X. Ruiz, Alexandra Cousido-Siah, Andre Mitschler, Alberto Podjarny, Firas Fadel, Yuguang Zhao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0154190 (2016)
PLoS ONE, Vol 11, Iss 4, p e0154190 (2016)
Chitinases are enzymes that catalyze the hydrolysis of chitin. Human chitotriosidase (CHIT1) is one of the two active human chitinases, involved in the innate immune response and highly expressed in a variety of diseases. CHIT1 is composed of a catal
Autor:
Marta Domínguez, Jesús Ángel de la Fuente, Alberto Podjarny, Alexandra Cousido-Siah, María Jesús Martín, Angel R. de Lera, F.X. Ruiz, C. Rechlin, Jaume Farrés, Gerhard Klebe, Isidro Crespo, Andre Mitschler, Sergio Porté, Xavier Parés
Publikováno v:
ChemMedChem. 10:1941-1941
Autor:
Fadel, Firas, Zhao, Yuguang, Cousido-Siah, Alexandra, Ruiz, Francesc X., Mitschler, André, Podjarny, Alberto
Publikováno v:
PLoS ONE; 4/25/2016, Vol. 11 Issue 4, p1-15, 15p
Autor:
Odile Bars, Pierre Braunstein, Andre Mitschler, Jean Fischer, Daniel Grandjean, M. Louër, Dominique Matt
Publikováno v:
Journal of Organometallic Chemistry. 213:79-107
Reaction of cis -PtCl 2 (PPh 2 Cl) 2 with NaMn(CO) 5 in tetrahydrofuran yields new tri- and tetrametallic platinum-manganese complexes. The substitution of the PtCl and PCl bonds is accompanied by a redox reaction, a labilization of the PtP
Autor:
Andre Mitschler, Yves Dusausoy, Pierre Braunstein, Louis Ricard, Jean Fischer, Dominique Matt
Publikováno v:
Journal of the American Chemical Society. 103:5115-5125