Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hitoshi Endou"'
Publikováno v:
Kidney & Blood Pressure Research, Pp 1-12 (2020)
Introduction: The kidneys play a central role in eliminating metabolic waste products and drugs through transporter-mediated excretion along the proximal tubule. This task is mostly achieved through a variety of transporters from the solute carrier f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c285f4a57db4c884ac2a1535fb3324be
https://www.zora.uzh.ch/id/eprint/188462/
https://www.zora.uzh.ch/id/eprint/188462/
Autor:
Promsuk Jutabha, B Quade, Hitoshi Endou, T Iwen, M Frick, Michael F. Wempe, Peter J. Rice, S Wakui
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 30:1312-1323
The current study describes the chemical synthesis of a series of (2-ethylbenzofuran-3-yl)(substituted-phenyl)methanone compounds and their subsequent in vitro testing via oocytes expressing hURAT1. The experimental data support the notion that a pot
Autor:
Hitoshi Endou, Naohiko Anzai
Publikováno v:
Seminars in Nephrology. 31:400-409
Urate (uric acid) is the end product of purine metabolism in human beings owing to the genetic loss of hepatic urate oxidase (uricase). Despite its potential advantage as an antioxidant, sustained hyperuricemia is associated with gout, renal diseases
Autor:
Peter J. Rice, Morin M. Frick, Naohiko Anzai, Ian R. Ross, Promsuk Jutabha, Timothy J. Iwen, Michael F. Wempe, Bettina Quade, Hitoshi Endou
Publikováno v:
Journal of Medicinal Chemistry. 54:2701-2713
The kidneys are a vital organ in the human body. They serve several purposes including homeostatic functions such as regulating extracellular fluid volume, maintaining acid-base and electrolyte balance, and are essential regarding the excretion of me
Autor:
Hitoshi Endou, Daisaku Miura, Toru Kimura, Michio Takeda, Takeshi Sakata, Hiroyuki Sakurai, Toshiyuki Fukutomi, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 3, Pp 263-266 (2010)
We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibi
Autor:
Promsuk Jutabha, Hiroyuki Sakurai, Naohiko Anzai, Hitoshi Endou, Sunena Srivastava, Kimiyoshi Ichida, Chun Ji Jin, Toru Kimura, Ichiro Hisatome, Kenichiro Kitamura, Ellappan Babu
Publikováno v:
Journal of Biological Chemistry. 283:26834-26838
Hyperuricemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases. Although renal excretion largely determines plasma urate concentration, the molecular mechanism of renal urate handling remains elusive. Previ
Publikováno v:
Current Opinion in Rheumatology. 19:151-157
This review focuses on recent progress in the understanding of various aspects of renal transport of urate.Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of
Publikováno v:
American Journal of Physiology-Renal Physiology. 290:F251-F261
Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A ( SLCO), and the multi
Autor:
Hitoshi Endou, Atsushi Enomoto
Publikováno v:
Clinical and Experimental Nephrology. 9:195-205
Renal proximal and distal tubules are highly polarized epithelial cells that carry out the specialized directional transport of various solutes. This renal function, which is essential for homeostasis in the body, is achieved through the close pairin
Autor:
Suparat Khamdang, Taku Hirata, Arthit Chairoungdua, Rie Noshiro, Hitoshi Endou, Atsushi Enomoto, Yoshikatsu Kanai, Shinichi Sakamoto, Hiroki Miyazaki, Ho-Jung Shin, Kimio Tomita, Naohiko Anzai
Publikováno v:
Journal of Biological Chemistry. 279:45942-45950
The urate-anion exchanger URAT1 is a member of the organic anion transporter (OAT) family that regulates blood urate level in humans and is targeted by uricosuric and antiuricosuric agents. URAT1 is expressed only in the kidney, where it is thought t