Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug therapy
Autor:
Xinxin Song, Haroon A. Choudry, Yong J. Lee, Yong Tae Kwon, Young Sun Lee, David L. Bartlett, Ashok K. Dilly, Dae Hee Lee
Publikováno v:
Molecular Cancer Research. 16:1077-1091
Emerging evidence demonstrates that autophagy and apoptosis are interconnected and their interplay greatly affects cell death. However, the key regulators in this crosstalk remain elusive. Therefore, the role of N-terminal arginylated BiP (R-BiP)/Bec
Autor:
Yong J. Lee
Publikováno v:
Cancer Research. 80:1239-1239
Ferroptosis has been reported as a unique form of cell death. However, in recent years, researchers have increasingly challenged the uniqueness of ferroptosis compared to other types of cell death. In this study, we examined whether ferroptosis share
Autor:
Lisa Bailey, David L. Bartlett, Xinxin Song, Se Hoon Hong, William T. Kwon, Yong J. Lee, Yong Tae Kwon, Per H. Basse
Publikováno v:
Molecular Cancer Therapeutics. 15:1591-1601
Since its discovery in 1995, TNF-related apoptosis-inducing ligand (TRAIL) has sparked growing interest among oncologists due to its remarkable ability to induce apoptosis in malignant human cells, but not in most normal cells. However, one major dra
Autor:
Ashok K. Dilly, Yong J. Lee, Yong Tae Kwon, David L. Bartlett, Haroon A. Choudry, Xinxin Song
Publikováno v:
Molecular Cancer Research. 13:1533-1543
Colorectal peritoneal carcinomatosis (CPC) exhibits severe tumor hypoxia, leading to drug resistance and disease aggressiveness. This study demonstrates that the combination of the chemotherapeutic agent mitomycin C with the proteasome inhibitor bort
Autor:
Se Hoon Hong, Dae-Hee Lee, Young-Sun Lee, Min Jee Jo, Yoon A Jeong, William T. Kwon, Haroon A. Choudry, David L. Bartlett, Yong J. Lee
Publikováno v:
Oncotarget
Ferroptosis is a type of programmed cell death that depends on iron and is characterized by the accumulation of lipid peroxides. In the present study, we investigated the nature of the interplay between ferroptosis and other forms of cell death such
Publikováno v:
Molecular cancer research : MCR. 16(7)
Since its discovery in 2012, ferroptosis has been well characterized by the accumulation of lipid peroxides due to the failure of glutathione-dependent antioxidant defenses. It is known as an iron-dependent form of programmed cell death, which is dis
Autor:
Herbert J. Zeh, Yong J. Lee, Haroon A. Choudry, Brendon D. Honick, Z S Guo, David L. Bartlett, Ashok K. Dilly
Publikováno v:
Oncotarget
// Ashok K. Dilly 1 , Brendon D. Honick 1 , Yong J. Lee 1, 2 , Zong S. Guo 1 , Herbert J. Zeh 1 , David L. Bartlett 1 and Haroon A. Choudry 1 1 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh PA 15232, USA 2 Department of P
Autor:
Yong J. Lee, Dae Hee Lee, Haroon A. Choudry, Min Jee Jo, David L. Bartlett, Young Sun Lee, William T. Kwon, Yoon A. Jeong, Se Hoon Hong
Publikováno v:
Oncotarget
Ferroptosis is a type of programmed cell death that depends on iron and is characterized by the accumulation of lipid peroxides. In the present study, we investigated the nature of the interplay between ferroptosis and other forms of cell death such
Autor:
Yong J. Lee
Publikováno v:
Cancer Research. 79:707-707
Introduction: Several processes lead to cell death; ferroptosis, apoptosis, necrosis, and autophagy are the primary mechanisms. Each type of biological death has been believed to have a distinct biochemical and morphological fingerprint. However, eme