Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ronald Herbst"'
Autor:
Yashaswi Shrestha, Ronald Herbst, Rajiv Raja, Maria Libera Ascierto, Michael Oberst, Philip Martin, Melissa de los Reyes, Nabendu Pore, Raymond Rothstein, John Meekin, Ashok K. Gupta, Melanie M. Frigault, Stephen Blackmore, Ina Bisha, Nathan Standifer, Shaad Essa Abdullah, Theresa Proia, Matthew Griffin, Phillip A. Dennis, Rebecca A. Halpin, Song Wu, Ricardo J Miragaia, Kathy Mulgrew, J. Carl Barrett, Maria Jure-Kunkel
Publikováno v:
Cancer Discovery. 11:2828-2845
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Autor:
Kristen Arnold, Chris Morehouse, Eleanor Clancy-Thompson, Katharina Deschler, Susannah Hewitt, Russell Karp, Ameya Apte, Chris Bagnall, Faith Musenge, Darren Potz, David A. Leinster, Kathy Mulgrew, Ankita Mishra, Gordon Moody, Maja Sedic, Joshua Frederick, John Zielinski, Fabien Garcon, Sushma Gurumurthy, Nadia Luheshi, Michal Sulikowski, Steve Novick, Han Si, Philip Martin, Grace Adjei, James Moynihan, Jean-Martin Lapointe, Amanda Watkins, Shannon Burke, Ronald Herbst, Dyane Bailey, Robert W. Wilkinson
Publikováno v:
Clinical Cancer Research. 26:6284-6298
Purpose: While immune checkpoint inhibitors such as anti–PD-L1 are rapidly becoming the standard of care in the treatment of many cancers, only a subset of treated patients have long-term responses. IL12 promotes antitumor immunity in mouse models;
Publikováno v:
Clinical Cancer Research. 26:332-339
Tumors evolve in close interaction with their microenvironment, which encompasses a continual tension between the developing tumor and the host immune system. Clinical trials have shown that appropriate enhancement of a tumor immune response can lead
Autor:
Hanane Ouakrim, P Morel, Angéline Duché, Marco Alifano, Diane Damotte, Pascaline Boudou-Rouquette, Camille Tlemsani, Sarah Warren, Jérôme Biton, Alessandra Cesano, Rebecca Halpin, Claire Gervais, Nora Kramkimel, Han Si, Jennifer Arrondeau, Todd Creasy, Audrey Bellesoeur, Barbara Burroni, Ronald Herbst, Franck Letourneur, Xing Ren, Audrey Mansuet-Lupo, Karen Leroy, François Goldwasser
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Journal of Translational Medicine
Journal of Translational Medicine
Background The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its ability to predict clinical benefit of immunotherapy in cancer patients treated
Autor:
Jay Harper, Ravinder Tammali, David A. Tice, Brandon W. Higgs, Nicholas Holoweckyj, Christine Fazenbaker, Jing Zhang, James Conway, Cui Chen, Shannon Breen, Haihong Zhong, Maureen Kennedy, Andrew J. Pierce, Ronald Herbst, Rajiv Raja
Publikováno v:
Molecular Cancer Therapeutics. 18:89-99
Pyrrolobenzodiazepine dimers (PBD) form cross-links within the minor groove of DNA causing double-strand breaks (DSB). DNA repair genes such as BRCA1 and BRCA2 play important roles in homologous recombination repair of DSB. We hypothesized that PBD-b
Autor:
Philip Howard, Cui Tracy Chen, Haihong Zhong, Nazzareno Dimasi, John Meekin, Paul Hynes, David A. Tice, Kenneth C. Anderson, Elaine M. Hurt, Xiaodong Xiao, Krista Kinneer, Reena Varkey, Yu-Tzu Tai, Ronald Herbst, Ryan Fleming, Shannon Breen, Suneetha Thomas, Binyam Bezabeh, Leslie Wetzel, Ruoyan Chen, Matt Flynn
Publikováno v:
Leukemia. 33:766-771
Autor:
Luke A. Masterson, Sonja Hess, Howard Philip Wilson, Andrew Garcia, Kimberly M Cook, Kathryn M. Pugh, Wen Yu, Hong Chen, Allison M. Barrett, Ronald Herbst, Shenlan Mao, Changshou Gao, David A. Tice, Mark Cobbold, Herren Wu, Jens-Oliver Koopmann, Ryan Fleming, Jay Harper, Susan Wilson, Raghothama Chaerkady, Gina DAngelo, Sandrina Phipps, Nazzareno Dimasi
Publikováno v:
Molecular cancer therapeutics. 20(3)
Resistance to antibody–drug conjugates (ADCs) has been observed in both preclinical models and clinical studies. However, mechanisms of resistance to pyrrolobenzodiazepine (PBD)-conjugated ADCs have not been well characterized and thus, this study
Autor:
Ashenafi Y. Tilahun, Andrew Leishman, Richard J. A. Goodwin, John P. Vasilakos, Robert W. Wilkinson, John G. Swales, Nadia Luheshi, Elina Timosenko, Ronald Herbst, James Elvecrog, Stefanie R. Mullins, Simon J. Dovedi, Pete Gillis, Zachary A. Cooper, Iwen Grigsby, Katharina Deschler, Julius John, Matthew J. Elder, Mark A. Tomai
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Background Immune checkpoint blockade (ICB) promotes adaptive immunity and tumor regression in some cancer patients. However, in patients with immunologically “cold” tumors, tumor-resident innate immune cell activation may be required to prime an
Autor:
John Meekin, Haihong Zhong, Maureen Kennedy, Rosa A. Carrasco, Ronald Herbst, Sandrina Phipps, Binyam Bezabeh, R. James Christie, Karma Dacosta, David A. Tice, Emily E. Bosco, Jiping Zha, Rakesh Dixit, Partha S. Chowdhury, Joanne Ayriss, Qun Du, Zhan Xiao, Darrin Sabol, MaryJane Hinrichs, Cui Chen, Shannon Breen, Lee Brown, Molly Reed
Publikováno v:
Oncotarget
Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. A greater understanding of the molecular characteristics of breast tumors could ultimately lead to improved tumor-targeted
Autor:
Tianxia Wu, Ruturaj R. Masvekar, Ronald Herbst, Keith Tan, Yue Wang, Panagiotis Douvaras, Mika Komori, Bibiana Bielekova, Mark C. Greenwood, Valentina Fossati, Christopher Barbour, Kory R. Johnson, Peter Kosa, Makoto Tanigawa
Publikováno v:
Annals of Neurology. 82:795-812
Objective: Biomarkers aid diagnosis, allow inexpensive screening of therapies and guide selection of patient-specific therapeutic regimens in most internal medicine disciplines. In contrast, neurology lacks validated measurements of the physiological