Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Robert Somerville"'
Autor:
Martin Ongkeko, Sandhya R. Panch, Amy Wahba, Kamille A. West, Patrick Danaher, Christina Bailey, David F. Stroncek, Leonard Chen, Inna Dzekunova, Mallikarjuna Rao Gedda, Robert Somerville, Jin Ping, Valeria De Giorgi, Mame Thioye Sall, Opal Reddy, Lipei Saho
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCoronavirus disease 2019 (COVID-19) results in robust but dysregulated acute immune response characterized by pro-inflammatory cytokine production and T-cell exhaustion, but little is known concerning immune response following recovery. We
Autor:
Scott Kivitz, Gal Cafri, Drew C. Deniger, Steven A. Rosenberg, Parisa Malekzadeh, Paul F. Robbins, Biman C. Paria, Rami Yossef, Mark Raffeld, Nicholas P. Restifo, Amy R. Copeland, Satyajit Ray, Maria R. Parkhurst, Robert Somerville, Sang-hyun Kim, Meghan L. Good, Zhiya Yu, Abraham Sachs, Liqiang Xi, Frank J. Lowery, Mohammad S. Jafferji
Publikováno v:
Clin Cancer Res
Purpose: The purpose of this study was to evaluate antigen experienced T cells in peripheral blood lymphocytes (PBL) for responses to p53 neoantigens. Experimental Design: PBLs from patients with a mutated TP53 tumor were sorted for antigen-experienc
Autor:
Steven A. Rosenberg, Rami Yossef, Anna Pasetto, Jared J. Gartner, David N. Danforth, Li Jia, Parisa Malekzadeh, John R. Wunderlich, Biman C. Paria, Drew C. Deniger, Michelle M. Langhan, Robert Somerville, Paul F. Robbins, Todd D. Prickett
Publikováno v:
Clinical Cancer Research. 24:5562-5573
Purpose: This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic ovarian cancers. Patients and Methods: Tumor-infiltrating lymphocytes (TIL) were expanded from re
Autor:
Harshini Chinnasamy, Todd D. Prickett, Li Jia, Paul F. Robbins, Isaac R. Kriley, Yasmine Assadipour, Steven A. Rosenberg, Steven A. Feldman, Stephanie L. Goff, Jared J. Gartner, Nikolaos Zacharakis, Jessica S. Crystal, John R. Wunderlich, Yong-Chen Lu, Robert Somerville, Mary A. Black, Lily Lu, Hui Xu, Zhili Zheng
Publikováno v:
Clinical Cancer Research. 23:4347-4353
Purpose: The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There are limite
Autor:
Chihao Zhao, Michelle M. Langhan, Christopher Chow-Parmer, Robert Somerville, Zulmarie Franco, Maria R. Parkhurst, Steven A. Rosenberg, Nathan Wong, Paul D. Robbins, Raul Gil-Hoyos, Ken-ichi Hanada, James Chih-Hsin Yang, Prickett D. Todd, John R. Wunderlich, Zachary Rae, Sri Krishna, Scott Kivitz, David N. Danforth, Jared J. Gartner, Kelly Michael, Samuel C. Chatmon, Frank J. Lowery, Thomas E. Shelton
Publikováno v:
Cancer Research. 81:1509-1509
The correlations between tumor mutational load and higher response rates to immune-checkpoint inhibitor (ICI) therapies revealed the importance of targeting tumor neoantigens in cancer immunotherapy. Although ICI therapy has been revolutionary, many
Autor:
Steven A. Rosenberg, Arvind Sabesan, John R. Wunderlich, David N. Danforth, Christopher A. Klebanoff, Stephanie L. Goff, Mary Ann Toomey, Liqiang Xi, Daniel Zlott, Robert Somerville, James Chih-Hsin Yang, Mark Raffeld, Donald E. White, Trinh Hoc Tran Pham, Smita S. Chandran, Richard M. Sherry, Abhishek K. Srivastava, Udai S. Kammula, Biman C. Paria
Publikováno v:
The Lancet Oncology. 18:792-802
Summary Background Uveal melanoma is a rare tumour with no established treatments once metastases develop. Although a variety of immune-based therapies have shown efficacy in metastatic cutaneous melanoma, their use in ocular variants has been disapp
Autor:
John R. Wunderlich, Paul F. Robbins, Anna Pasetto, Li Jia, Mona El-Gamil, Gal Cafri, Maria R. Parkhurst, Eric Tran, Yong F. Li, Lien T. Ngo, Winifred Lo, Robert Somerville, Mojgan Ahmadzadeh, Jessica S. Crystal, Todd D. Prickett, Gabriel Ivey, Satyajit Ray, Frank J. Lowery, Rami Yossef, Abraham Sachs, Steven A. Rosenberg, Almin Lalani, Scott Kivitz, Eric M. Groh, Drew C. Deniger, Parisa Malekzadeh, Stephanie L. Goff, Jared J. Gartner
Publikováno v:
Cancer discovery. 9(8)
Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes
Autor:
John R. Wunderlich, Robert Somerville, Udai S. Kammula, James Chih-Hsin Yang, Richard M. Sherry, Steven A. Rosenberg, Sarah R. Helman, Mei Li M. Kwong, Michelle M. Langhan, Christopher A. Klebanoff, Stacey L. Doran, Christian S. Hinrichs, Sanja Stevanović
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(5)
Purpose: Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated tumor-infiltrating lymphocyte (TIL) therapy for the treatment of patients with metastatic hu
Autor:
John R. Wunderlich, Daniel J. Stephens, Liqiang Xi, Biman C. Paria, Smita S. Chandran, Arvind Sabesan, Mark Raffeld, Parthav Jailwala, Manjula Kasoji, Robert Somerville, Chyi-Chia Richard Lee, Trinh Hoc Tran Pham, Luke D. Rothermel, Abhishek K. Srivastava, Udai S. Kammula
Publikováno v:
Clinical Cancer Research. 22:2237-2249
Purpose: Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor
Autor:
Y Assadipour, Steven A. Feldman, Todd D. Prickett, Mary A. Black, John R. Wunderlich, Harshini Chinnasamy, M Statler, Paul F. Robbins, Stephanie L. Goff, Hui Xu, I Kriley, Lily Lu, Nikolaos Zacharakis, Robert Somerville, Steven A. Rosenberg, Jared J. Gartner
Publikováno v:
Cancer Research. 77:P2-04
Background & Translational Relevance: Adoptive transfer of tumor infiltrating lymphocytes (TIL) can effect long-term durable regression in patients with metastatic melanoma but has not been widely tested in common epithelial cancers. When examining t