Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Philip Martin"'
Autor:
Eric Tu, Kelly McGlinchey, Jixin Wang, Philip Martin, Steven L.K. Ching, Nicolas Floc’h, James Kurasawa, Jacqueline H. Starrett, Yelena Lazdun, Leslie Wetzel, Barrett Nuttall, Felicia S.L. Ng, Karen T. Coffman, Paul D. Smith, Katerina Politi, Zachary A. Cooper, Katie Streicher
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Treatment with anti–PD-1 and anti-PD-L1 therapies has shown durable clinical benefit in non–small cell lung cancer (NSCLC). However, patients with NSCLC with epidermal growth factor receptor (EGFR) mutations do not respond as well to treatment as
Externí odkaz:
https://doaj.org/article/c6a5fda9646e49b8adcbb817d655948e
Autor:
Johanna Bendell, Patricia LoRusso, Michael Overman, Anne M. Noonan, Dong-Wan Kim, John H. Strickler, Sang-We Kim, Stephen Clarke, Thomas J. George, Peter S. Grimison, Minal Barve, Manik Amin, Jayesh Desai, Trisha Wise-Draper, Steven Eck, Yu Jiang, Anis A. Khan, Yuling Wu, Philip Martin, Zachary A. Cooper, Nairouz Elgeioushi, Nancy Mueller, Rakesh Kumar, Sandip Pravin Patel
Publikováno v:
Cancer Immunology, Immunotherapy.
Background CD73 upregulation in tumors leads to local immunosuppression. This phase I, first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ monoclonal antibody, alone or with durvalumab in patients with advanced colorectal c
Autor:
Yashaswi Shrestha, Ronald Herbst, Rajiv Raja, Maria Libera Ascierto, Michael Oberst, Philip Martin, Melissa de los Reyes, Nabendu Pore, Raymond Rothstein, John Meekin, Ashok K. Gupta, Melanie M. Frigault, Stephen Blackmore, Ina Bisha, Nathan Standifer, Shaad Essa Abdullah, Theresa Proia, Matthew Griffin, Phillip A. Dennis, Rebecca A. Halpin, Song Wu, Ricardo J Miragaia, Kathy Mulgrew, J. Carl Barrett, Maria Jure-Kunkel
Publikováno v:
Cancer Discovery. 11:2828-2845
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Publikováno v:
Cancers. 14(16)
Radiomics is a field of medical imaging analysis that focuses on the extraction of many quantitative imaging features related to shape, intensity and texture. These features are incorporated into models designed to predict important clinical or biolo
Autor:
Kristen Arnold, Chris Morehouse, Eleanor Clancy-Thompson, Katharina Deschler, Susannah Hewitt, Russell Karp, Ameya Apte, Chris Bagnall, Faith Musenge, Darren Potz, David A. Leinster, Kathy Mulgrew, Ankita Mishra, Gordon Moody, Maja Sedic, Joshua Frederick, John Zielinski, Fabien Garcon, Sushma Gurumurthy, Nadia Luheshi, Michal Sulikowski, Steve Novick, Han Si, Philip Martin, Grace Adjei, James Moynihan, Jean-Martin Lapointe, Amanda Watkins, Shannon Burke, Ronald Herbst, Dyane Bailey, Robert W. Wilkinson
Publikováno v:
Clinical Cancer Research. 26:6284-6298
Purpose: While immune checkpoint inhibitors such as anti–PD-L1 are rapidly becoming the standard of care in the treatment of many cancers, only a subset of treated patients have long-term responses. IL12 promotes antitumor immunity in mouse models;
Autor:
Edward Chan, Philip Martin, Caterina Brighi, Sugendran Pillay, Lois Holloway, Peter Metcalfe, Eng-Siew Koh
Publikováno v:
Neuro-Oncology. 24:vii182-vii182
BACKGROUND Accurate and repeatable imaging segmentation of glioblastomas is important for effective radiomics modelling of clinical endpoints such as survival and treatment response. Manual and even automated segmentation are prone to variability. Th
Autor:
Christopher Browning Cole, Maria Pia Morelli, Massimo Fantini, Maria Fergusson, Sharon A. Mavroukakis, Anjum Zaki, Kwong Y. Tsang, Philip Martin Arlen, Christina M. Annunziata
Publikováno v:
Journal of Clinical Oncology. 40:2531-2531
2531 Background: NEO201 is a humanized IgG1 monoclonal antibody generated against tumor-associated antigens from colorectal cancer which binds specifically to tumor-associated CEACAM-5 and CEACAM-6 variants without binding CECAM 5/6 on normal epithel
Autor:
Fiona Hyland, Janice Au-Young, Vinay K. Mittal, Ruchi Chaudhary, Luca Quagliata, Dinesh Cyanam, Jermann Philip Martin, Ilaria Alborelli, Seth Sadis, Warren Tom
Publikováno v:
Translational lung cancer research. 7(6)
Background: Tumor mutational burden (TMB) is an increasingly important biomarker for immune checkpoint inhibitors. Recent publications have described strong association between high TMB and objective response to mono- and combination immunotherapies
Autor:
Johannes Zimmermann, Keith Steele, Lorenz Rognoni, Moritz Widmaier, Katrin Schneider, Tobias Wiestler, Anmarie Boutrin, Brian Laffin, Jiping Zha, Tze Heng Tan, Karma Dacosta, Philip Martin, Charles Brown, René Korn, Ruben Cardenes, Michael Kuziora
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Background Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important measures of the immune response to cancer with prognostic, pharmacodynamic, and
Autor:
Binyam Bezabeh, Jonathan Rios-Doria, Jon Chesebrough, Philip Martin, David Stewart, John Meekin, Patrick Strout, Emil Michelotti, Raymond Rothstein, Cui Chen, Leslie Wetzel, Kelly McGlinchey, Robert E. Hollingsworth, Andrew Buchanan, Maureen Kennedy, Nazzareno Dimasi, Kathy Mulgrew, Ryan Fleming, Allison M. Marrero, Jay Harper
Publikováno v:
Cancer research. 77(10)
Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrro